| MeSH term | MeSH ID | Detail |
|---|---|---|
| Asthma, Exercise-Induced | D001250 | 10 associated lipids |
| Rhinitis | D012220 | 10 associated lipids |
| Influenza, Human | D007251 | 11 associated lipids |
| Airway Obstruction | D000402 | 13 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
| Bronchial Hyperreactivity | D016535 | 15 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Respiratory Hypersensitivity | D012130 | 18 associated lipids |
| Cough | D003371 | 19 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
LTD4
Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTD4?
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTD4
PubChem Associated disorders and diseases
What pathways are associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTD4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTD4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTD4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTD4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTD4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTD4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wen FQ et al. | Eicosanoid profile in cultured human pulmonary artery smooth muscle cells treated with IL-1 beta and TNF alpha. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9758210 |
| Ohbayashi H et al. | Compared effects of natriuretic peptides on ovalbumin-induced asthmatic model. | 1998 | Eur. J. Pharmacol. | pmid:9617752 |
| Kohno S | [Role of peptide-leukotrienes in bronchial asthma]. | 1998 | Nippon Yakurigaku Zasshi | pmid:9618707 |
| Gorenne I et al. | Leukotriene D4 contractions in human airways are blocked by SK&F 96365, an inhibitor of receptor-mediated calcium entry. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9454796 |
| Kimura K et al. | Modulation of platelet activating factor-induced glycogenolysis in the perfused rat liver after administration of endotoxin in vivo. | 1998 | J. Biochem. | pmid:9504421 |
| Capra V et al. | Identification and characterization of two cysteinyl-leukotriene high affinity binding sites with receptor characteristics in human lung parenchyma. | 1998 | Mol. Pharmacol. | pmid:9547367 |
| von Sprecher A et al. | Synthesis and SAR of a novel, potent and structurally simple LTD4 antagonist of the quinoline class. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9871521 |
| Zwaagstra ME et al. | Synthesis and structure-activity relationships of carboxyflavones as structurally rigid CysLT1 (LTD4) receptor antagonists. | 1998 | J. Med. Chem. | pmid:9554876 |
| Habib GM et al. | Leukotriene D4 and cystinyl-bis-glycine metabolism in membrane-bound dipeptidase-deficient mice. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9560193 |
| Venugopalan CS et al. | Responses of guinea-pig lung parenchymal strips to tracheobronchial lavage fluid from horses affected with summer pasture-associated obstructive pulmonary disease. | 1998 | Vet. Res. Commun. | pmid:9868763 |
| Geirsson A et al. | Potentiating effects of pertussis toxin on leukotriene C4 induced formation of inositol phosphate and prostacyclin in human umbilical vein endothelial cells. | 1998 | J. Cell. Physiol. | pmid:9731750 |
| Massoumi R and Sjölander A | The inflammatory mediator leukotriene D4 triggers a rapid reorganisation of the actin cytoskeleton in human intestinal epithelial cells. | 1998 | Eur. J. Cell Biol. | pmid:9716265 |
| Shirasaki H et al. | The effect of a cysteinyl leukotriene antagonist, ONO-1078 (pranlukast) on agonist- and antigen-induced nasal microvascular leakage in guinea pigs. | 1998 | Rhinology | pmid:9695159 |
| Nagase T and Ludwig MS | Antigen-induced responses in lung parenchymal strips during sinusoidal oscillation. | 1998 | Can. J. Physiol. Pharmacol. | pmid:9635157 |
| Ohbayashi H et al. | Neutral endopeptidase 3.4.24.11 inhibition potentiates the inhibitory effects of type-C natriuretic peptide on leukotriene D4-induced airway changes. | 1998 | Clin. Exp. Pharmacol. Physiol. | pmid:9887994 |
| Underwood DC et al. | Antiasthmatic activity of the second-generation phosphodiesterase 4 (PDE4) inhibitor SB 207499 (Ariflo) in the guinea pig. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9864284 |
| Fujimura M et al. | A partial involvement of histamine in ultrasonically nebulized distilled water-induced bronchoconstriction in guinea-pigs. | 1998 | Br. J. Pharmacol. | pmid:9831931 |
| Kawashima Y et al. | Surface-modified antiasthmatic dry powder aerosols inhaled intratracheally reduce the pharmacologically effective dose. | 1998 | Pharm. Res. | pmid:9833999 |
| Allen S et al. | Differential leukotriene constrictor responses in human atherosclerotic coronary arteries. | 1998 | Circulation | pmid:9641692 |
| Sato E et al. | Acetylcholine stimulates alveolar macrophages to release inflammatory cell chemotactic activity. | 1998 | Am. J. Physiol. | pmid:9609736 |