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1995 |
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1995 |
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1995 |
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1995 |
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1995 |
Hepatology |
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Pharmacology of montelukast sodium (Singulair), a potent and selective leukotriene D4 receptor antagonist. |
1995 |
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1995 |
Cell Calcium |
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1995 |
Toxicology |
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Prostaglandins Leukot. Essent. Fatty Acids |
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Effect of a selective thromboxane A2 receptor antagonist BAY u3405 on antigen-, leukotriene C4- and leukotriene D4-induced bronchoconstriction in guinea pigs. |
1995 |
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1995 |
Prostaglandins |
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Cysteinyl-leukotriene D4 induced IL-1 beta expression and release in rat vascular smooth muscle cells. |
1995 |
Atherosclerosis |
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Antiinflammatory and analgesic activity of CP-96,345: an orally active non-peptide substance P receptor antagonist. |
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Chronic sinusitis: characterization of cellular influx and inflammatory mediators in sinus lavage fluid. |
1995 |
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Synergism exhibited by LTD4 and PAF receptor antagonists in decreasing antigen-induced airway microvascular leakage. |
1995 |
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Endogenous sulfidopeptide leukotriene synthesis and 12-lipoxygenase activity in bullfrog (Rana catesbeiana) erythrocytes. |
1995 |
Biochim. Biophys. Acta |
pmid:7734448
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The reproducibility and effect on non-specific airway responsiveness of inhaled prostaglandin D2 and leukotriene D4 in asthmatic subjects. |
1995 |
Br J Clin Pharmacol |
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Calcium-induced long-lasting potentiation of GABAergic currents in cerebellar Purkinje cells. |
1994 |
Jpn. J. Physiol. |
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Modulation of rat vascular smooth muscle cell (VSMC) proliferation by cysteinyl leukotriene D4: a role for mediation of interleukin 1. |
1995 |
Atherosclerosis |
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The leukotriene D4-receptor antagonist, ICI 204,219, relieves symptoms of acute seasonal allergic rhinitis. |
1995 |
Am. J. Respir. Crit. Care Med. |
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Sensitivity of ovine myometrial tissue to various eicosanoids in vitro. |
1995 |
Prostaglandins |
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Antagonism of leukotriene responses in human airways by BAY x7195. |
1995 |
Eur. J. Pharmacol. |
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Inhibitory effect of ONO-1078 on specific binding of peptide leukotrienes to human lung crude membrane. |
1994 |
Prostaglandins Leukot. Essent. Fatty Acids |
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1994 |
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1994 |
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Inhibition by a novel peptide leukotriene receptor antagonist ONO-1078 of airway wall thickening and airway hyperresponsiveness to histamine induced by leukotriene C4 or leukotriene D4 in guinea-pigs. |
1994 |
Clin. Exp. Allergy |
pmid:7842366
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Petric R and Ford-Hutchinson AW |
Elevated cysteinyl leukotriene excretion in experimental glomerulonephritis. |
1994 |
Kidney Int. |
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Beneficial effects of combined thromboxane and leukotriene receptor antagonism in hemorrhagic shock. |
1995 |
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Effect of BAY x 7195, an oral receptor antagonist of cysteinyl-leukotrienes, on leukotriene D4-induced bronchoconstriction in normal volunteers. |
1994 |
Eur. J. Clin. Pharmacol. |
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Ganbo T et al. |
Inhibition of mucociliary clearance of the eustachian tube by leukotrienes C4 and D4. |
1995 |
Ann. Otol. Rhinol. Laryngol. |
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Protective effect of peptide leukotriene antagonist on renal failure induced by a tourniquet in rabbits. |
1995 |
Forensic Sci. Int. |
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Preparation and pharmacological activities of 10-homolupinanoyl-2-R-phenothiazines. |
1994 |
Farmaco |
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Molecular and functional characterization of recombinant human gamma-glutamyltransferase. Coupling of its activity to glutathione levels in V79 cells. |
1994 |
Eur. J. Biochem. |
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IL-1 beta regulates the expression of the Gi2 alpha gene via lipid mediators in guinea pig tracheal muscle. |
1994 |
Biochem. Biophys. Res. Commun. |
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The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. |
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1994 |
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Simplified sulfidoleukotriene ELISA using LTD4-conjugated phosphatase for the study of allergen-induced leukotriene generation by isolated mononuclear cells and diluted whole blood. |
1994 May-Jun |
J Investig Allergol Clin Immunol |
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1994 |
Eur. J. Pharmacol. |
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Induction of peroxisomal enzymes by a tetrazole-substituted 2-quinolinylmethoxy leukotriene D4 antagonist. |
1994 |
Fundam Appl Toxicol |
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Respiratory tract eicosanoid measurement using microdialysis sampling and GC/MS detection. |
1994 |
Pulm Pharmacol |
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1994 |
Am. J. Respir. Crit. Care Med. |
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Evaluation of bronchoconstriction induced by neurokinins and its inhibition by selective nonpeptide antagonists in conscious guinea pigs, using a double-chamber plethysmograph technique. |
1994 |
Can. J. Physiol. Pharmacol. |
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Effect of an inhaled neutral endopeptidase inhibitor, thiorphan, on airway responsiveness to leukotriene D4 in normal and asthmatic subjects. |
1994 |
Eur. Respir. J. |
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Leukotriene D4-induced increases in cytosolic calcium in THP-1 cells: dependence on extracellular calcium and inhibition with selective leukotriene D4 receptor antagonists. |
1994 |
J. Pharmacol. Exp. Ther. |
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Leukotriene D4 depresses the mechanosensitivity of group III and IV muscle receptors in the rat. |
1994 |
Neuroreport |
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Effect of a 5-lipoxygenase inhibitor and leukotriene antagonist (PF 5901) on antigen-induced airway responses in neonatally immunized rabbits. |
1994 |
Br. J. Pharmacol. |
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Underwood DC et al. |
Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs. |
1994 |
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Characterization of specific binding sites for cysteinyl leukotrienes in sheep lung. |
1994 |
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The effect of short-chain fatty acids on Cl- and K+ conductance in rat colonic crypts. |
1994 |
Pflugers Arch. |
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Molecular cloning of sheep lung dipeptidase: a glycosyl phosphatidylinositol-anchored ectoenzyme that converts leukotriene D4 to leukotriene E4. |
1994 |
Biochim. Biophys. Acta |
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Leukotriene D4-induced mucosal damage during long observation periods in vitro. |
1994 |
Prostaglandins |
pmid:8066186
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Phosphoramidon augments contraction of guinea pig tracheal smooth muscle induced by histamine and leukotriene-D4. |
1994 |
Int. Arch. Allergy Immunol. |
pmid:8111247
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Role of cysteinyl-leukotrienes and histamine in mediating intrinsic tone in isolated human bronchi. |
1994 |
Am. J. Respir. Crit. Care Med. |
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Intravascular cysteinyl-leukotriene formation by clotting whole human blood. Evidence from clamped umbilical vein segments and thrombus specimens. |
1993 |
Thromb. Res. |
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Application of totally automated on-line sample clean up system for extraction and high-performance liquid chromatography separation of peptide leukotrienes. |
1993 Nov-Dec |
J Pharm Biomed Anal |
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Enhanced synthesis of cysteinyl leukotrienes in juvenile rheumatoid arthritis. |
1994 |
Arthritis Rheum. |
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Effect of RG 12525, a new leukotriene antagonist, on pulmonary function of asthmatic adults. |
1994 |
Ann Allergy |
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The leukotriene-antagonist ICI-204,219 inhibits the early airway reaction to cumulative bronchial challenge with allergen in atopic asthmatics. |
1994 |
Eur. Respir. J. |
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Differential tissue expression of immunoreactive dehydropeptidase I, a peptidyl leukotriene metabolizing enzyme. |
1994 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:8171072
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Short term effects of indomethacin on rat small intestinal permeability. Role of eicosanoids and platelet activating factor. |
1994 |
Gut |
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Neural and myogenic effects of leukotrienes C4, D4, and E4 on canine bronchial smooth muscle. |
1994 |
Am. J. Physiol. |
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Involvement of immunologic mechanisms in a guinea pig model of western red cedar asthma. |
1994 |
J. Allergy Clin. Immunol. |
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Plasma and urinary leukotrienes in sickle cell disease: possible role in the inflammatory process. |
1994 |
Eur. J. Clin. Invest. |
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Protein kinase C-dependent regulation of sulfidopeptide leukotriene biosynthesis and leukotriene C4 synthase in neutrophilic HL-60 cells. |
1994 |
Mol. Pharmacol. |
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Effects of LTD4 and its specific antagonist L-660,711 in isolated rat hearts with chronic myocardial infarction. |
1994 |
Am. J. Physiol. |
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Mechanism of leukotriene D4 stimulation of Cl- secretion in rat distal colon in vitro. |
1993 |
Am. J. Physiol. |
pmid:8214069
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Pawloski JR and Chapnick BM |
Antagonism of LTD4-evoked relaxation in canine renal artery and vein. |
1993 |
Am. J. Physiol. |
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Manning PJ et al. |
Exercise-induced refractoriness in asthmatic subjects involves leukotriene and prostaglandin interdependent mechanisms. |
1993 |
Am. Rev. Respir. Dis. |
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Leukotriene D4- and prostaglandin F2 alpha-induced airflow obstruction and airway plasma exudation in guinea-pig: role of thromboxane and its receptor. |
1993 |
Br. J. Pharmacol. |
pmid:8220872
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Smith LJ et al. |
Inhibition of leukotriene D4-induced bronchoconstriction in subjects with asthma: a concentration-effect study of ICI 204,219. |
1993 |
Clin. Pharmacol. Ther. |
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Yoshikawa S et al. |
Modulation of acetylcholine release from the myenteric plexus of guinea-pig ileum by 5-lipoxygenase metabolites of arachidonic acid. |
1993 |
Eur. J. Pharmacol. |
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Krauss AH and Woodward DF |
Polymorphonuclear leukocyte infiltration into the subretinal choroid and optic nerve in response to leukotrienes. |
1993 |
Invest. Ophthalmol. Vis. Sci. |
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Volume regulation in human fibroblasts: role of Ca2+ and 5-lipoxygenase products in the activation of the Cl- efflux. |
1993 |
J. Membr. Biol. |
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Comparison of leukotriene B4 and D4 effects on human eosinophil and neutrophil motility in vitro. |
1994 |
J. Leukoc. Biol. |
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Determination of leukotriene effects on human neutrophil chemotaxis in vitro by differential assessment of cell motility and polarity. |
1994 |
J. Leukoc. Biol. |
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Correlation between leukotriene D4-induced contraction and cytosolic calcium elevation: a quantitative and simultaneous evaluation in smooth muscle. |
1994 |
J. Pharmacol. Exp. Ther. |
pmid:8301553
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Leukotrienes mediate antigen-induced airway hyper-reactivity in guinea pigs. |
1994 |
J. Pharmacol. Exp. Ther. |
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Lee TH and Christie PE |
Leukotrienes and aspirin induced asthma. |
1993 |
Thorax |
pmid:8303620
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Dahlén B et al. |
Effect of the leukotriene receptor antagonist MK-0679 on baseline pulmonary function in aspirin sensitive asthmatic subjects. |
1993 |
Thorax |
pmid:8303624
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Nathan RA et al. |
Inhaled ICI 204,219 blocks antigen-induced bronchoconstriction in subjects with bronchial asthma. |
1994 |
Chest |
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Helvering LM et al. |
H-ras 61st codon activation in archival proliferative hepatic lesions isolated from female B6C3F1 mice exposed to the leukotriene D4-antagonist, LY171883. |
1994 |
Carcinogenesis |
pmid:8313527
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Metters KM and Zamboni RJ |
Photoaffinity labeling of the leukotriene D4 receptor in guinea pig lung. |
1993 |
J. Biol. Chem. |
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Shikada K and Tanaka S |
Influence of epithelium on the inhibition of melittin-induced contraction of guinea-pig isolated trachea by the potassium channel opener NIP-121. |
1993 |
Br. J. Pharmacol. |
pmid:8401920
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Diener M and Scharrer E |
The leukotriene D4 receptor blocker, SK&F 104353, inhibits volume regulation in isolated crypts from the rat distal colon. |
1993 |
Eur. J. Pharmacol. |
pmid:8405093
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Conroy DM et al. |
Relaxant effects of pituitary adenylate cyclase activating polypeptide (PACAP) on epithelium-intact and -denuded guinea-pig trachea: a comparison with vasoactive intestinal peptide (VIP). |
1995 |
Neuropeptides |
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Howell RE et al. |
Pulmonary pharmacology of WAY-126299A: a dual-acting 5-lipoxygenase inhibitor and leukotriene D4 antagonist. |
1995 |
Inflamm. Res. |
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