| MeSH term | MeSH ID | Detail |
|---|---|---|
| Reperfusion Injury | D015427 | 65 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Glomerulonephritis | D005921 | 35 associated lipids |
| Neuralgia | D009437 | 28 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
| Endotoxemia | D019446 | 27 associated lipids |
| Leukemia, Lymphocytic, Chronic, B-Cell | D015451 | 25 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
LTD4
Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTD4?
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTD4
PubChem Associated disorders and diseases
What pathways are associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTD4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTD4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTD4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTD4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTD4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTD4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Vargaftig BB and Singer M | Leukotrienes mediate part of Ova-induced lung effects in mice via EGFR. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12794006 |
| Vargaftig BB and Singer M | Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13. | 2003 | Am. J. Respir. Cell Mol. Biol. | pmid:12654629 |
| Kawano T et al. | Cysteinyl leukotrienes induce nuclear factor kappa b activation and RANTES production in a murine model of asthma. | 2003 | J. Allergy Clin. Immunol. | pmid:12897744 |
| Paruchuri S and Sjölander A | Leukotriene D4 mediates survival and proliferation via separate but parallel pathways in the human intestinal epithelial cell line Int 407. | 2003 | J. Biol. Chem. | pmid:12912998 |
| Suzuki M et al. | Inhibition of human eosinophil activation by a cysteinyl leukotriene receptor antagonist (pranlukast; ONO-1078). | 2003 | J Asthma | pmid:12870835 |
| Massoumi R et al. | Leukotriene D4-induced adhesion of Caco-2 cells is mediated by prostaglandin E2 and upregulation of alpha2beta1-integrin. | 2003 | Exp. Cell Res. | pmid:14499635 |
| Thompson MD et al. | A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha. | 2003 | Pharmacogenetics | pmid:14515063 |
| Capra V et al. | Involvement of prenylated proteins in calcium signaling induced by LTD4 in differentiated U937 cells. | 2003 | Prostaglandins Other Lipid Mediat. | pmid:14518564 |
| Kurogi Y | Mesangial cell proliferation inhibitors for the treatment of proliferative glomerular disease. | 2003 | Med Res Rev | pmid:12424751 |
| Marusova IB et al. | [Potential gastroprotective effect of a CysLT1 receptor blocker sodium montelukast in aspirin-induced lesions of the rat stomach mucosa]. | 2002 May-Jun | Eksp Klin Farmakol | pmid:12227087 |
| McMahon B et al. | Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation. | 2002 | FASEB J. | pmid:12223454 |
| Thodeti CK and Sjölander A | Leukotriene D4-induced calcium signaling in human intestinal epithelial cells. | 2002 | Adv. Exp. Med. Biol. | pmid:12664584 |
| Shahbazian A et al. | Differential peristaltic motor effects of prostanoid (DP, EP, IP, TP) and leukotriene receptor agonists in the guinea-pig isolated small intestine. | 2002 | Br. J. Pharmacol. | pmid:12429577 |
| Walch L et al. | Pharmacological evidence for a novel cysteinyl-leukotriene receptor subtype in human pulmonary artery smooth muscle. | 2002 | Br. J. Pharmacol. | pmid:12466244 |
| Neu IS et al. | Leukotrienes in patients with clinically active multiple sclerosis. | 2002 | Acta Neurol. Scand. | pmid:11903112 |
| Braccioni F et al. | The effect of cysteinyl leukotrienes on growth of eosinophil progenitors from peripheral blood and bone marrow of atopic subjects. | 2002 | J. Allergy Clin. Immunol. | pmid:12110827 |
| Bandeira-Melo C et al. | Cysteinyl leukotrienes induce IL-4 release from cord blood-derived human eosinophils. | 2002 | J. Allergy Clin. Immunol. | pmid:12063527 |
| Uemura M et al. | Cysteinyl leukotrienes in the bile of patients with obstructive jaundice. | 2002 | J. Gastroenterol. | pmid:12424566 |
| Lee KH et al. | Increased expression of endothelial cell adhesion molecules due to mediator release from human foreskin mast cells stimulated by autoantibodies in chronic urticaria sera. | 2002 | J. Invest. Dermatol. | pmid:11918713 |
| Evans JF | Cysteinyl leukotriene receptors. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12432945 |