| MeSH term | MeSH ID | Detail |
|---|---|---|
| Rhinitis | D012220 | 10 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Glomerulonephritis | D005921 | 35 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
LTD4
Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTD4?
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTD4
PubChem Associated disorders and diseases
What pathways are associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTD4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTD4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTD4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTD4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTD4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTD4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shahbazian A et al. | Differential peristaltic motor effects of prostanoid (DP, EP, IP, TP) and leukotriene receptor agonists in the guinea-pig isolated small intestine. | 2002 | Br. J. Pharmacol. | pmid:12429577 |
| Walch L et al. | Pharmacological evidence for a novel cysteinyl-leukotriene receptor subtype in human pulmonary artery smooth muscle. | 2002 | Br. J. Pharmacol. | pmid:12466244 |
| Neu IS et al. | Leukotrienes in patients with clinically active multiple sclerosis. | 2002 | Acta Neurol. Scand. | pmid:11903112 |
| Sakata K and Bäck M | Receptor preferences of cysteinyl-leukotrienes in the guinea pig lung parenchyma. | 2002 | Eur. J. Pharmacol. | pmid:11834255 |
| Braccioni F et al. | The effect of cysteinyl leukotrienes on growth of eosinophil progenitors from peripheral blood and bone marrow of atopic subjects. | 2002 | J. Allergy Clin. Immunol. | pmid:12110827 |
| Bandeira-Melo C et al. | Cysteinyl leukotrienes induce IL-4 release from cord blood-derived human eosinophils. | 2002 | J. Allergy Clin. Immunol. | pmid:12063527 |
| Uemura M et al. | Cysteinyl leukotrienes in the bile of patients with obstructive jaundice. | 2002 | J. Gastroenterol. | pmid:12424566 |
| Li PC et al. | Enhanced activity of Ca2+-activated K+ channels by 1-[2-hydroxy-3-propyl-4-[(1H-tetrazol-5-yl)butoxyl]phenyl] ethanone (LY-171883) in neuroendocrine and neuroblastoma cell lines. | 2002 | J. Cell. Physiol. | pmid:12115725 |
| Massoumi R et al. | Leukotriene D(4) induces stress-fibre formation in intestinal epithelial cells via activation of RhoA and PKCdelta. | 2002 | J. Cell. Sci. | pmid:12154081 |
| Han B et al. | Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo. | 2002 | Am. J. Pathol. | pmid:12163373 |
| Paruchuri S et al. | Leukotriene D(4) activates MAPK through a Ras-independent but PKCepsilon-dependent pathway in intestinal epithelial cells. | 2002 | J. Cell. Sci. | pmid:11956320 |
| Stelmach I et al. | [The effect of inhaled heparin on post-leukotriene bronchoconstriction in children with bronchial asthma]. | 2002 | Pol. Merkur. Lekarski | pmid:11995261 |
| Allakhverdi Z et al. | Inhibition of antigen-induced eosinophilia and airway hyperresponsiveness by antisense oligonucleotides directed against the common beta chain of IL-3, IL-5, GM-CSF receptors in a rat model of allergic asthma. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:11934731 |
| Lavoie JP et al. | Comparison of effects of dexamethasone and the leukotriene D4 receptor antagonist L-708,738 on lung function and airway cytologic findings in horses with recurrent airway obstruction. | 2002 | Am. J. Vet. Res. | pmid:11939323 |
| Nagata M et al. | Leukotriene D4 upregulates eosinophil adhesion via the cysteinyl leukotriene 1 receptor. | 2002 | J. Allergy Clin. Immunol. | pmid:11941318 |
| Evans JF | Cysteinyl leukotriene receptors. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12432945 |
| Ketchell RI et al. | Contrasting effects of allergen challenge on airway responsiveness to cysteinyl leukotriene D(4) and methacholine in mild asthma. | 2002 | Thorax | pmid:12096198 |
| Shirasaki H et al. | Expression and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa. | 2002 | Clin. Exp. Allergy | pmid:12100046 |
| Thodeti CK et al. | Leukotriene D4 induces association of active RhoA with phospholipase C-gamma1 in intestinal epithelial cells. | 2002 | Biochem. J. | pmid:12071848 |
| Bäck M | Functional characteristics of cysteinyl-leukotriene receptor subtypes. | 2002 | Life Sci. | pmid:12072150 |