| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cough | D003371 | 19 associated lipids |
| Respiratory Hypersensitivity | D012130 | 18 associated lipids |
| Bronchial Hyperreactivity | D016535 | 15 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
| Airway Obstruction | D000402 | 13 associated lipids |
| Influenza, Human | D007251 | 11 associated lipids |
| Rhinitis | D012220 | 10 associated lipids |
| Respiratory Syncytial Virus Infections | D018357 | 10 associated lipids |
| Asthma, Exercise-Induced | D001250 | 10 associated lipids |
LTD4
Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTD4?
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTD4
PubChem Associated disorders and diseases
What pathways are associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTD4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTD4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTD4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTD4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTD4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTD4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Leier I et al. | The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. | 1994 | J. Biol. Chem. | pmid:7961706 |
| Bannenberg G et al. | Leukotriene C4 is a tight-binding inhibitor of microsomal glutathione transferase-1. Effects of leukotriene pathway modifiers. | 1999 | J. Biol. Chem. | pmid:9890956 |
| Garcia C et al. | Effects of synthetic peptido-leukotrienes on bone resorption in vitro. | 1996 | J. Bone Miner. Res. | pmid:8992883 |
| Fang SH et al. | Pranlukast attenuates ischemia-like injury in endothelial cells via inhibiting reactive oxygen species production and nuclear factor-kappaB activation. | 2009 | J. Cardiovasc. Pharmacol. | pmid:19129732 |
| Kim MH et al. | Effect of leukotriene D4 on mouse embryonic stem cell migration and proliferation: involvement of PI3K/Akt as well as GSK-3β/β-catenin signaling pathways. | 2010 | J. Cell. Biochem. | pmid:20589831 |
| Cosentino S et al. | Expression of dual nucleotides/cysteinyl-leukotrienes receptor GPR17 in early trafficking of cardiac stromal cells after myocardial infarction. | 2014 | J. Cell. Mol. Med. | pmid:24909956 |
| Geirsson A et al. | Potentiating effects of pertussis toxin on leukotriene C4 induced formation of inositol phosphate and prostacyclin in human umbilical vein endothelial cells. | 1998 | J. Cell. Physiol. | pmid:9731750 |
| Al-Azzam N et al. | Modulation of mast cell proliferative and inflammatory responses by leukotriene d4 and stem cell factor signaling interactions. | 2015 | J. Cell. Physiol. | pmid:25161061 |
| Li PC et al. | Enhanced activity of Ca2+-activated K+ channels by 1-[2-hydroxy-3-propyl-4-[(1H-tetrazol-5-yl)butoxyl]phenyl] ethanone (LY-171883) in neuroendocrine and neuroblastoma cell lines. | 2002 | J. Cell. Physiol. | pmid:12115725 |
| Capra V et al. | CysLT1 receptor is a target for extracellular nucleotide-induced heterologous desensitization: a possible feedback mechanism in inflammation. | 2005 | J. Cell. Sci. | pmid:16306225 |
| Massoumi R and Sjölander A | Leukotriene D(4) affects localisation of vinculin in intestinal epithelial cells via distinct tyrosine kinase and protein kinase C controlled events. | 2001 | J. Cell. Sci. | pmid:11329379 |
| Massoumi R et al. | Leukotriene D(4) induces stress-fibre formation in intestinal epithelial cells via activation of RhoA and PKCdelta. | 2002 | J. Cell. Sci. | pmid:12154081 |
| Paruchuri S et al. | Leukotriene D(4) activates MAPK through a Ras-independent but PKCepsilon-dependent pathway in intestinal epithelial cells. | 2002 | J. Cell. Sci. | pmid:11956320 |
| Meng XJ et al. | Leukotriene D4 activates a chloride conductance in hepatocytes from lipopolysaccharide-treated rats. | 1997 | J. Clin. Invest. | pmid:9185515 |
| Soberman RJ and Christmas P | The organization and consequences of eicosanoid signaling. | 2003 | J. Clin. Invest. | pmid:12697726 |
| Datta HK et al. | Parathyroid hormone induces superoxide anion burst in the osteoclast: evidence for the direct instantaneous activation of the osteoclast by the hormone. | 1996 | J. Endocrinol. | pmid:8708538 |
| Bandeira-Melo C et al. | Intracrine cysteinyl leukotriene receptor-mediated signaling of eosinophil vesicular transport-mediated interleukin-4 secretion. | 2002 | J. Exp. Med. | pmid:12235216 |
| Uemura M et al. | Cysteinyl leukotrienes in the bile of patients with obstructive jaundice. | 2002 | J. Gastroenterol. | pmid:12424566 |
| Gyömber E et al. | Effect of lipoxygenase inhibitors and leukotriene antagonists on acute and chronic gastric haemorrhagic mucosal lesions in ulcer models in the rat. | 1996 | J. Gastroenterol. Hepatol. | pmid:8912128 |
| Lefebvre B et al. | Effect of 5-lipoxygenase blockade on blood pressure and acetylcholine-evoked endothelium-dependent contraction in aorta from spontaneously hypertensive rats. | 2006 | J. Hypertens. | pmid:16331105 |