| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cough | D003371 | 19 associated lipids |
| Respiratory Hypersensitivity | D012130 | 18 associated lipids |
| Bronchial Hyperreactivity | D016535 | 15 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
| Airway Obstruction | D000402 | 13 associated lipids |
| Influenza, Human | D007251 | 11 associated lipids |
| Rhinitis | D012220 | 10 associated lipids |
| Respiratory Syncytial Virus Infections | D018357 | 10 associated lipids |
| Asthma, Exercise-Induced | D001250 | 10 associated lipids |
LTD4
Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTD4?
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTD4
PubChem Associated disorders and diseases
What pathways are associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTD4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTD4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTD4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTD4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTD4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTD4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mayatepek E et al. | Synthesis and metabolism of leukotrienes in gamma-glutamyl transpeptidase deficiency. | 2004 | J. Lipid Res. | pmid:14754911 |
| Ge H et al. | Elucidation of signaling and functional activities of an orphan GPCR, GPR81. | 2008 | J. Lipid Res. | pmid:18174606 |
| Lukic A et al. | Pulmonary epithelial cancer cells and their exosomes metabolize myeloid cell-derived leukotriene C4 to leukotriene D4. | 2016 | J. Lipid Res. | pmid:27436590 |
| Zhang MQ et al. | (Piperidinylalkoxy)chromones: novel antihistamines with additional antagonistic activity against leukotriene D4. | 1995 | J. Med. Chem. | pmid:7608912 |
| Zwaagstra ME et al. | Synthesis and structure-activity relationships of carboxyflavones as structurally rigid CysLT1 (LTD4) receptor antagonists. | 1998 | J. Med. Chem. | pmid:9554876 |
| Jorgensen NK et al. | Role of LTD4 in the regulatory volume decrease response in Ehrlich ascites tumor cells. | 1996 | J. Membr. Biol. | pmid:8661498 |
| Pedersen S et al. | Leukotriene D4-induced Ca2+ mobilization in Ehrlich ascites tumor cells. | 1997 | J. Membr. Biol. | pmid:9002425 |
| Mastrocola T et al. | Volume regulation in human fibroblasts: role of Ca2+ and 5-lipoxygenase products in the activation of the Cl- efflux. | 1993 | J. Membr. Biol. | pmid:8271272 |
| Wang Y et al. | Induction of LTD in the dentate gyrus in vitro is NMDA receptor independent, but dependent on Ca2+ influx via low-voltage-activated Ca2+ channels and release of Ca2+ from intracellular stores. | 1997 | J. Neurophysiol. | pmid:9065852 |
| Basavappa S et al. | Swelling-induced arachidonic acid release via the 85-kDa cPLA2 in human neuroblastoma cells. | 1998 | J. Neurophysiol. | pmid:9497423 |
| Guo HF and Zhong Y | Requirement of Akt to mediate long-term synaptic depression in Drosophila. | 2006 | J. Neurosci. | pmid:16611817 |
| Farias S et al. | Injury-related production of cysteinyl leukotrienes contributes to brain damage following experimental traumatic brain injury. | 2009 | J. Neurotrauma | pmid:19886806 |
| Sundström E et al. | Interactions among three classes of mediators explain antigen-induced bronchoconstriction in the isolated perfused and ventilated guinea pig lung. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12954791 |
| Underwood DC et al. | SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence. | 2000 | J. Pharmacol. Exp. Ther. | pmid:10734180 |
| Daniele S et al. | Agonist-induced desensitization/resensitization of human G protein-coupled receptor 17: a functional cross-talk between purinergic and cysteinyl-leukotriene ligands. | 2011 | J. Pharmacol. Exp. Ther. | pmid:21531793 |
| Wong WS et al. | Effects of tyrosine kinase inhibitors on antigen challenge of guinea pig lung in vitro. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9336317 |
| Arakida Y et al. | In vitro pharmacologic profile of YM158, a new dual antagonist for LTD4 and TXA2 receptors. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9808690 |
| Aoki M et al. | Studies on mechanisms of low emetogenicity of YM976, a novel phosphodiesterase type 4 inhibitor. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11504812 |
| Ni NC et al. | A selective cysteinyl leukotriene receptor 2 antagonist blocks myocardial ischemia/reperfusion injury and vascular permeability in mice. | 2011 | J. Pharmacol. Exp. Ther. | pmid:21903747 |
| Underwood DC et al. | Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs. | 1994 | J. Pharmacol. Exp. Ther. | pmid:8035322 |