White IJ et al. |
A continuous fluorometric assay for leukotriene D4 hydrolase. |
1999 |
Anal. Biochem. |
pmid:10075814
|
Welch MJ et al. |
Effect of RG 12525, a new leukotriene antagonist, on pulmonary function of asthmatic adults. |
1994 |
Ann Allergy |
pmid:8154635
|
Hendeles L and Marshik PL |
Zileuton: a new therapy for asthma or just the first of a new class of drugs. |
1996 Jul-Aug |
Ann Pharmacother |
pmid:8826576
|
Kim SH et al. |
Regulation of monocyte chemoattractant protein 1 by cysteinyl leukotriene D4 in human lung epithelial A549 cells. |
2009 |
Ann. Allergy Asthma Immunol. |
pmid:19852204
|
Smith LJ et al. |
A single dose of zafirlukast reduces LTD4-induced bronchoconstriction in patients on maintenance inhaled corticosteroid therapy. |
1998 |
Ann. Allergy Asthma Immunol. |
pmid:9690572
|
Shirasaki H et al. |
Agonist- and T(H)2 cytokine-induced up-regulation of cysteinyl leukotriene receptor messenger RNA in human monocytes. |
2007 |
Ann. Allergy Asthma Immunol. |
pmid:17941281
|
Saito K et al. |
Leukotriene D4 and eosinophil transendothelial migration, superoxide generation, and degranulation via beta2 integrin. |
2004 |
Ann. Allergy Asthma Immunol. |
pmid:15609771
|
Simons FE et al. |
Suppression of the early and late cutaneous allergic responses using fexofenadine and montelukast. |
2001 |
Ann. Allergy Asthma Immunol. |
pmid:11206237
|
Sjölander A and Grönroos E |
Leukotriene D4-induced signal transduction. |
1994 |
Ann. N. Y. Acad. Sci. |
pmid:7825836
|
Krell RD et al. |
Preclinical exploration of the potential antiinflammatory properties of the peptide leukotriene antagonist ICI 204,219 (Accolate). |
1994 |
Ann. N. Y. Acad. Sci. |
pmid:7825851
|
Möhle R et al. |
Transendothelial migration of hematopoietic progenitor cells. Role of chemotactic factors. |
2001 |
Ann. N. Y. Acad. Sci. |
pmid:11458515
|
Mayatepek E et al. |
A patient with neurological symptoms and abnormal leukotriene metabolism: a new defect in leukotriene biosynthesis. |
2005 |
Ann. Neurol. |
pmid:16315285
|
Konno A et al. |
Role of substance P in the vascular response of nasal mucosa in nasal allergy. |
1996 |
Ann. Otol. Rhinol. Laryngol. |
pmid:8712637
|
Ganbo T et al. |
Inhibition of mucociliary clearance of the eustachian tube by leukotrienes C4 and D4. |
1995 |
Ann. Otol. Rhinol. Laryngol. |
pmid:7872607
|
Abe M et al. |
A novel method for preserving human lungs using a super-cooling system. |
2006 |
Ann. Thorac. Surg. |
pmid:16928543
|
Hoopes C |
Invited commentary. |
2006 |
Ann. Thorac. Surg. |
pmid:16928544
|
Marcelle R |
Leukotrienes antagonist-inhibitor and the bronchial response to inhaled antigen in actively sensitized guinea-pigs. |
1998 |
Arch. Physiol. Biochem. |
pmid:9711356
|
Kawagishi Y et al. |
[Clinical significance of measurement of urinary leukotriene E4 in asthmatic patients without attack]. |
2001 |
Arerugi |
pmid:11761885
|
Fauler J et al. |
Enhanced synthesis of cysteinyl leukotrienes in juvenile rheumatoid arthritis. |
1994 |
Arthritis Rheum. |
pmid:8129769
|
Ganbo T et al. |
Effect of ibudilast on ciliary activity of human paranasal sinus mucosa in vitro. |
1995 |
Arzneimittelforschung |
pmid:7575753
|
Nakamura S et al. |
Effects of 1-[3-(4-benzhydryl-1-piperazinyl)propyl]-3- (1H-imidazol-1-ylmethyl)-1H-indole-6-carboxylic acid with thromboxane A2 synthetase inhibitory and H1-blocking activities on anaphylactic bronchospasm. |
1996 |
Arzneimittelforschung |
pmid:8955866
|
Tasaka K et al. |
Effect of loratadine on immediate and delayed type hypersensitivity reactions. |
1995 |
Arzneimittelforschung |
pmid:8573225
|
Kumasawa F et al. |
Mitogen-activated protein kinase (MAPK) regulates leukotriene D4-induced HB-EGF and ADAM12 expression in human airway smooth muscle cells. |
2013 |
Asian Pac. J. Allergy Immunol. |
pmid:23517395
|
Porreca E et al. |
Modulation of rat vascular smooth muscle cell (VSMC) proliferation by cysteinyl leukotriene D4: a role for mediation of interleukin 1. |
1995 |
Atherosclerosis |
pmid:7755646
|
Porreca E et al. |
Cysteinyl-leukotriene D4 induced IL-1 beta expression and release in rat vascular smooth muscle cells. |
1995 |
Atherosclerosis |
pmid:7661877
|
Tada N et al. |
Experimental otitis media with effusion induced by leukotriene D4. |
2002 |
Auris Nasus Larynx |
pmid:11893446
|
Chiba Y et al. |
Regional differences in vascular responsiveness of nasal mucosae isolated from naive guinea pigs. |
2007 |
Auris Nasus Larynx |
pmid:17056219
|
Bai CH et al. |
The inhibitory effect of the leukotriene receptor antagonist on leukotriene D4-induced MUC2/5AC gene expression and mucin secretion in human airway epithelial cells. |
2007 |
Auris Nasus Larynx |
pmid:17223000
|
Hirata F et al. |
IL-1 beta regulates the expression of the Gi2 alpha gene via lipid mediators in guinea pig tracheal muscle. |
1994 |
Biochem. Biophys. Res. Commun. |
pmid:7945342
|
Adolfsson JL et al. |
Leukotriene D4-induced activation and translocation of the G-protein alpha i3-subunit in human epithelial cells. |
1996 |
Biochem. Biophys. Res. Commun. |
pmid:8806649
|
Wang ML et al. |
Leukotriene D4 induces brain edema and enhances CysLT2 receptor-mediated aquaporin 4 expression. |
2006 |
Biochem. Biophys. Res. Commun. |
pmid:17010308
|
Wikström K et al. |
The anti-apoptotic effect of leukotriene D4 involves the prevention of caspase 8 activation and Bid cleavage. |
2003 |
Biochem. J. |
pmid:12482325
|
Grönroos E et al. |
Leukotriene D4-induced mobilization of intracellular Ca2+ in epithelial cells is critically dependent on activation of the small GTP-binding protein Rho. |
1996 |
Biochem. J. |
pmid:8645211
|
Thodeti CK et al. |
Leukotriene D4 induces association of active RhoA with phospholipase C-gamma1 in intestinal epithelial cells. |
2002 |
Biochem. J. |
pmid:12071848
|
Ravasi S et al. |
Pharmacological differences among CysLT(1) receptor antagonists with respect to LTC(4) and LTD(4) in human lung parenchyma. |
2002 |
Biochem. Pharmacol. |
pmid:11996896
|
Martin V et al. |
Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors. |
2001 |
Biochem. Pharmacol. |
pmid:11705452
|
Capra V et al. |
CysLT1 signal transduction in differentiated U937 cells involves the activation of the small GTP-binding protein Ras. |
2004 |
Biochem. Pharmacol. |
pmid:15041474
|
Nieves D and Moreno JJ |
Role of 5-lipoxygenase pathway in the regulation of RAW 264.7 macrophage proliferation. |
2006 |
Biochem. Pharmacol. |
pmid:16934759
|
Mezhybovska M et al. |
Pro-inflammatory mediator leukotriene D4 induces transcriptional activity of potentially oncogenic genes. |
2005 |
Biochem. Soc. Trans. |
pmid:16042577
|
Wulff T et al. |
Co-expression of mCysLT1 receptors and IK channels in Xenopus laevis oocytes elicits LTD4-stimulated IK current, independent of an increase in [Ca2+]i. |
2004 |
Biochim. Biophys. Acta |
pmid:14757222
|
Kawakami Y et al. |
Neutralization of leukotriene C4 and D4 activity by monoclonal and single-chain antibodies. |
2014 |
Biochim. Biophys. Acta |
pmid:24361619
|
An S et al. |
Molecular cloning of sheep lung dipeptidase: a glycosyl phosphatidylinositol-anchored ectoenzyme that converts leukotriene D4 to leukotriene E4. |
1994 |
Biochim. Biophys. Acta |
pmid:8054366
|
Gronert K et al. |
Endogenous sulfidopeptide leukotriene synthesis and 12-lipoxygenase activity in bullfrog (Rana catesbeiana) erythrocytes. |
1995 |
Biochim. Biophys. Acta |
pmid:7734448
|
Uno T et al. |
Participation of leukotriene D4 and tumor necrosis factor on lipopolysaccharide-induced airway hyperresponsiveness in guinea pigs. |
1997 |
Biol. Pharm. Bull. |
pmid:9145204
|
Tsuji T et al. |
Differential effects of beta2-adrenoceptor desensitization on the IgE-dependent release of chemical mediators from cultured human mast cells. |
2004 |
Biol. Pharm. Bull. |
pmid:15467193
|
Smyth TP et al. |
A substrate variant as a high-affinity, reversible inhibitor: insight from the X-ray structure of cilastatin bound to membrane dipeptidase. |
2003 |
Bioorg. Med. Chem. |
pmid:12614884
|
Maehr H and Yang R |
Structure optimization of a leukotriene D4 antagonist by combinatorial chemistry in solution. |
1997 |
Bioorg. Med. Chem. |
pmid:9113326
|
Tvaermose-Nielsen O et al. |
Discovery of OT4003, a novel, potent, and orally active cys-LT1 receptor antagonist. |
1997 |
Bioorg. Med. Chem. |
pmid:9061206
|
Hayashi S et al. |
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships. |
2010 |
Bioorg. Med. Chem. |
pmid:20875743
|
Germain AR et al. |
Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells. |
2013 |
Bioorg. Med. Chem. Lett. |
pmid:23403082
|
von Sprecher A et al. |
Synthesis and SAR of a novel, potent and structurally simple LTD4 antagonist of the quinoline class. |
1998 |
Bioorg. Med. Chem. Lett. |
pmid:9871521
|
Chambers RJ et al. |
Development of new chromanol antagonists of leukotriene D4. |
1998 |
Bioorg. Med. Chem. Lett. |
pmid:9873435
|
Macdonald D et al. |
Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein. |
2008 |
Bioorg. Med. Chem. Lett. |
pmid:18276139
|
Bouchelouche K et al. |
The action of cysteinyl-leukotrienes on intracellular calcium mobilization in human detrusor myocytes. |
2001 |
BJU Int. |
pmid:11350414
|
Lärfars G et al. |
Activation of nitric oxide release and oxidative metabolism by leukotrienes B4, C4, and D4 in human polymorphonuclear leukocytes. |
1999 |
Blood |
pmid:9949184
|
Dannull J et al. |
Leukotriene C4 induces migration of human monocyte-derived dendritic cells without loss of immunostimulatory function. |
2012 |
Blood |
pmid:22323449
|
Jiang Y et al. |
CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells. |
2007 |
Blood |
pmid:17693579
|
Bautz F et al. |
Chemotaxis and transendothelial migration of CD34(+) hematopoietic progenitor cells induced by the inflammatory mediator leukotriene D4 are mediated by the 7-transmembrane receptor CysLT1. |
2001 |
Blood |
pmid:11369634
|
Ito Y et al. |
Guinea pig cysteinyl leukotriene receptor 2 (gpCysLT2) mediates cell proliferation and intracellular calcium mobilization by LTC4 and LTD4. |
2008 |
BMB Rep |
pmid:18315950
|
Bellamkonda K et al. |
The eicosanoids leukotriene D4 and prostaglandin E2 promote the tumorigenicity of colon cancer-initiating cells in a xenograft mouse model. |
2016 |
BMC Cancer |
pmid:27388564
|
Linares Segovia B et al. |
Parameters of lung inflammation in asthmatic as compared to healthy children in a contaminated city. |
2014 |
BMC Pulm Med |
pmid:25000942
|
Schwartz JI et al. |
Oral pharmacokinetics and food interaction of the leukotriene D4 receptor antagonist verlukast. |
1993 |
Br J Clin Pharmacol |
pmid:12959296
|
Wensing G et al. |
Pharmacodynamics and pharmacokinetics of BAY x 7195 aerosol, a new and selective receptor antagonist of cysteinyl-leukotrienes, in normal volunteers. |
1996 |
Br J Clin Pharmacol |
pmid:8864314
|
Wood-Baker R et al. |
The reproducibility and effect on non-specific airway responsiveness of inhaled prostaglandin D2 and leukotriene D4 in asthmatic subjects. |
1995 |
Br J Clin Pharmacol |
pmid:7742148
|
Mezhybovska M et al. |
Beta-catenin is involved in alterations in mitochondrial activity in non-transformed intestinal epithelial and colon cancer cells. |
2009 |
Br. J. Cancer |
pmid:19826421
|
Taylor-Clark TE et al. |
Leukotriene D4 increases the excitability of capsaicin-sensitive nasal sensory nerves to electrical and chemical stimuli. |
2008 |
Br. J. Pharmacol. |
pmid:18500362
|
Murray J et al. |
Role of leukotrienes in the regulation of human granulocyte behaviour: dissociation between agonist-induced activation and retardation of apoptosis. |
2003 |
Br. J. Pharmacol. |
pmid:12770944
|
Mazzetti L et al. |
The ACh-induced contraction in rat aortas is mediated by the Cys Lt1 receptor via intracellular calcium mobilization in smooth muscle cells. |
2003 |
Br. J. Pharmacol. |
pmid:12598425
|
Francis HP et al. |
The effects of a novel sulphidopeptide leukotriene antagonist, BAY x7195, against elicited bronchoconstriction in the anaesthetized guinea-pig. |
1998 |
Br. J. Pharmacol. |
pmid:9484852
|
Capra V et al. |
Pharmacological characterization of the cysteinyl-leukotriene antagonists CGP 45715A (iralukast) and CGP 57698 in human airways in vitro. |
1998 |
Br. J. Pharmacol. |
pmid:9504401
|
Shahbazian A et al. |
Differential peristaltic motor effects of prostanoid (DP, EP, IP, TP) and leukotriene receptor agonists in the guinea-pig isolated small intestine. |
2002 |
Br. J. Pharmacol. |
pmid:12429577
|
Walch L et al. |
Pharmacological evidence for a novel cysteinyl-leukotriene receptor subtype in human pulmonary artery smooth muscle. |
2002 |
Br. J. Pharmacol. |
pmid:12466244
|
Bäck M et al. |
An alternative pathway for metabolism of leukotriene D(4): effects on contractions to cysteinyl-leukotrienes in the guinea-pig trachea. |
2001 |
Br. J. Pharmacol. |
pmid:11487525
|
Wunder F et al. |
Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT(2)) receptor. |
2010 |
Br. J. Pharmacol. |
pmid:20423349
|
Tsang F et al. |
Effects of mitogen-activated protein kinase kinase inhibitor PD 098059 on antigen challenge of guinea-pig airways in vitro. |
1998 |
Br. J. Pharmacol. |
pmid:9776345
|
Liu YC et al. |
Effects of the cysteinyl leukotriene receptor antagonists pranlukast and zafirlukast on tracheal mucus secretion in ovalbumin-sensitized guinea-pigs in vitro. |
1998 |
Br. J. Pharmacol. |
pmid:9647482
|
Ishimura M et al. |
Effects of KP-496, a novel dual antagonist at the cysteinyl leukotriene receptor 1 and the thromboxane A(2) receptor, on airway obstruction in guinea pigs. |
2008 |
Br. J. Pharmacol. |
pmid:18037905
|
Arakawa H et al. |
Leukotriene D4- and prostaglandin F2 alpha-induced airflow obstruction and airway plasma exudation in guinea-pig: role of thromboxane and its receptor. |
1993 |
Br. J. Pharmacol. |
pmid:8220872
|
Fujimura M et al. |
A partial involvement of histamine in ultrasonically nebulized distilled water-induced bronchoconstriction in guinea-pigs. |
1998 |
Br. J. Pharmacol. |
pmid:9831931
|
Hele DJ et al. |
Mediator involvement in antigen-induced bronchospasm and microvascular leakage in the airways of ovalbumin sensitized Brown Norway rats. |
2001 |
Br. J. Pharmacol. |
pmid:11159698
|
Snetkov VA et al. |
Mechanisms of leukotriene D4-induced constriction in human small bronchioles. |
2001 |
Br. J. Pharmacol. |
pmid:11350860
|
Herd CM et al. |
Effect of a 5-lipoxygenase inhibitor and leukotriene antagonist (PF 5901) on antigen-induced airway responses in neonatally immunized rabbits. |
1994 |
Br. J. Pharmacol. |
pmid:8032653
|
Shikada K and Tanaka S |
Influence of epithelium on the inhibition of melittin-induced contraction of guinea-pig isolated trachea by the potassium channel opener NIP-121. |
1993 |
Br. J. Pharmacol. |
pmid:8401920
|
Ortiz JL et al. |
Leukotriene receptors on human pulmonary vascular endothelium. |
1995 |
Br. J. Pharmacol. |
pmid:8564195
|
Sermasi E et al. |
Long term depression is expressed during postnatal development in rat visual cortex: a role for visual experience. |
1999 |
Brain Res. Dev. Brain Res. |
pmid:10064875
|
Jones TR et al. |
Pharmacology of montelukast sodium (Singulair), a potent and selective leukotriene D4 receptor antagonist. |
1995 |
Can. J. Physiol. Pharmacol. |
pmid:7621356
|
Yamashita T and Kokubun S |
Nonselective cationic currents activated by acetylcholine in swine tracheal smooth muscle cells. |
1999 |
Can. J. Physiol. Pharmacol. |
pmid:10588484
|
Nagase T and Ludwig MS |
Antigen-induced responses in lung parenchymal strips during sinusoidal oscillation. |
1998 |
Can. J. Physiol. Pharmacol. |
pmid:9635157
|
Chan CC et al. |
Evaluation of bronchoconstriction induced by neurokinins and its inhibition by selective nonpeptide antagonists in conscious guinea pigs, using a double-chamber plethysmograph technique. |
1994 |
Can. J. Physiol. Pharmacol. |
pmid:8012892
|
Nagayama S et al. |
Increased sensitivity to vincristine of MDR cells by the leukotriene D4 receptor antagonist, ONO-1078. |
1998 |
Cancer Lett. |
pmid:9751271
|
Nielsen CK et al. |
A novel localization of the G-protein-coupled CysLT1 receptor in the nucleus of colorectal adenocarcinoma cells. |
2005 |
Cancer Res. |
pmid:15705869
|
Helvering LM et al. |
H-ras 61st codon activation in archival proliferative hepatic lesions isolated from female B6C3F1 mice exposed to the leukotriene D4-antagonist, LY171883. |
1994 |
Carcinogenesis |
pmid:8313527
|
Parhamifar L et al. |
Activation of cPLA2 is required for leukotriene D4-induced proliferation in colon cancer cells. |
2005 |
Carcinogenesis |
pmid:15975962
|
Zhou G et al. |
Atorvastatin reduces plaque vulnerability in an atherosclerotic rabbit model by altering the 5-lipoxygenase pathway. |
2010 |
Cardiology |
pmid:20234134
|
Finkensieper A et al. |
The 5-lipoxygenase pathway regulates vasculogenesis in differentiating mouse embryonic stem cells. |
2010 |
Cardiovasc. Res. |
pmid:19965960
|
Chen C et al. |
Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC gamma mutant mice. |
1995 |
Cell |
pmid:8548809
|
Robbiani DF et al. |
The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes. |
2000 |
Cell |
pmid:11114332
|
Fukai F et al. |
Transcellular biosynthesis of cysteinyl leukotrienes by Kupffer cell-hepatocyte cooperation in rat liver. |
1996 |
Cell Biol. Int. |
pmid:8858827
|
Gorenne I et al. |
Antigen stimulation of human pulmonary smooth muscle: an in vitro model of inflammation. |
1996 |
Cell Biol. Toxicol. |
pmid:9034615
|
Grönroos E et al. |
Leukotriene D4 induces a rapid increase in cAMP in the human epithelial cell line, Int 407: a potential role for this signal in the regulation of calcium influx through the plasma membrane. |
1998 |
Cell Calcium |
pmid:9793684
|