| MeSH term | MeSH ID | Detail |
|---|---|---|
| Respiratory Hypersensitivity | D012130 | 18 associated lipids |
| Leukemia, Lymphocytic, Chronic, B-Cell | D015451 | 25 associated lipids |
| Otitis Media with Effusion | D010034 | 9 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Cough | D003371 | 19 associated lipids |
| Enteritis | D004751 | 8 associated lipids |
| Bronchial Hyperreactivity | D016535 | 15 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Influenza, Human | D007251 | 11 associated lipids |
| Asthma, Exercise-Induced | D001250 | 10 associated lipids |
LTD4
Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTD4?
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTD4
PubChem Associated disorders and diseases
What pathways are associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTD4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTD4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTD4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTD4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTD4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTD4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Forsell PK et al. | Metabolism of anandamide into eoxamides by 15-lipoxygenase-1 and glutathione transferases. | 2012 | Lipids | pmid:22684912 |
| Capra V et al. | Cysteinyl-leukotrienes and their receptors in asthma and other inflammatory diseases: critical update and emerging trends. | 2007 | Med Res Rev | pmid:16894531 |
| Kurogi Y | Mesangial cell proliferation inhibitors for the treatment of proliferative glomerular disease. | 2003 | Med Res Rev | pmid:12424751 |
| Bellamkonda K et al. | The impact of inflammatory lipid mediators on colon cancer-initiating cells. | 2015 | Mol. Carcinog. | pmid:25154976 |
| Shi ZZ et al. | Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D(4) synthesis in vivo and attenuation of the acute inflammatory response. | 2001 | Mol. Cell. Biol. | pmid:11463821 |
| Campos MR et al. | Differential kinase requirement for enhancement of Fc gammaR-mediated phagocytosis in alveolar macrophages by leukotriene B4 vs. D4. | 2009 | Mol. Immunol. | pmid:19223078 |
| Capra V et al. | Identification and characterization of two cysteinyl-leukotriene high affinity binding sites with receptor characteristics in human lung parenchyma. | 1998 | Mol. Pharmacol. | pmid:9547367 |
| Kargman S et al. | Protein kinase C-dependent regulation of sulfidopeptide leukotriene biosynthesis and leukotriene C4 synthase in neutrophilic HL-60 cells. | 1994 | Mol. Pharmacol. | pmid:8190095 |
| Sarau HM et al. | Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. | 1999 | Mol. Pharmacol. | pmid:10462554 |
| Ravasi S et al. | A kinetic binding study to evaluate the pharmacological profile of a specific leukotriene C(4) binding site not coupled to contraction in human lung parenchyma. | 2000 | Mol. Pharmacol. | pmid:10825389 |
| Nothacker HP et al. | Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist. | 2000 | Mol. Pharmacol. | pmid:11093801 |
| Zhao L et al. | The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm. | 2004 | Nat. Med. | pmid:15322539 |
| Lynch KR et al. | Characterization of the human cysteinyl leukotriene CysLT1 receptor. | 1999 | Nature | pmid:10391245 |
| Wang XY et al. | Leukotriene D4 induces amyloid-β generation via CysLT(1)R-mediated NF-κB pathways in primary neurons. | 2013 | Neurochem. Int. | pmid:23318673 |
| Schuhmann MU et al. | Temporal profiles of cerebrospinal fluid leukotrienes, brain edema and inflammatory response following experimental brain injury. | 2003 | Neurol. Res. | pmid:12866196 |
| Dudek SM and Friedlander MJ | Developmental down-regulation of LTD in cortical layer IV and its independence of modulation by inhibition. | 1996 | Neuron | pmid:8663986 |
| Conroy DM et al. | Relaxant effects of pituitary adenylate cyclase activating polypeptide (PACAP) on epithelium-intact and -denuded guinea-pig trachea: a comparison with vasoactive intestinal peptide (VIP). | 1995 | Neuropeptides | pmid:8538872 |
| Tang SS et al. | Leukotriene D4 induces cognitive impairment through enhancement of CysLT₠R-mediated amyloid-β generation in mice. | 2013 | Neuropharmacology | pmid:22982445 |
| Kang KH et al. | Protection of dopaminergic neurons by 5-lipoxygenase inhibitor. | 2013 | Neuropharmacology | pmid:23800665 |
| Hoheisel U and Mense S | Leukotriene D4 depresses the mechanosensitivity of group III and IV muscle receptors in the rat. | 1994 | Neuroreport | pmid:8025261 |
| Weiss SR et al. | Quenching: inhibition of development and expression of amygdala kindled seizures with low frequency stimulation. | 1995 | Neuroreport | pmid:8595196 |
| Nasuhara Y et al. | [Acyclovir and guinea-pig airway smooth muscle]. | 1995 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:7563998 |
| Kohno S | [Role of peptide-leukotrienes in bronchial asthma]. | 1998 | Nippon Yakurigaku Zasshi | pmid:9618707 |
| Chiba Y et al. | Effects of 1400W, a potent selective inducible NOS inhibitor, on histamine- and leukotriene D4-induced relaxation of isolated guinea pig nasal mucosa. | 2006 | Nitric Oxide | pmid:16442819 |
| Paruchuri S et al. | Endogenous production of leukotriene D4 mediates autocrine survival and proliferation via CysLT1 receptor signalling in intestinal epithelial cells. | 2006 | Oncogene | pmid:16715140 |
| Goto HG et al. | Induction of apoptosis in an estrogen-responsive mouse Leydig tumor cell by leukotriene. | 2007 | Oncol. Rep. | pmid:17143502 |
| Park SY et al. | Dehydropeptidase 1 promotes metastasis through regulation of E-cadherin expression in colon cancer. | 2016 | Oncotarget | pmid:26824987 |
| Cyrus CB et al. | Leukotrienes C4 and D4 increase the ciliary beat frequency in human upper airway mucosa in vitro. | 1998 | Otolaryngol Head Neck Surg | pmid:9560097 |
| Kopp MV et al. | Omalizumab (Xolair) in children with seasonal allergic rhinitis: leukotriene release as a potential in vitro parameter to monitor therapeutic effects. | 2007 | Pediatr Allergy Immunol | pmid:17680911 |
| Hougaard C et al. | K+ currents activated by leukotriene D4 or osmotic swelling in Ehrlich ascites tumour cells. | 2000 | Pflugers Arch. | pmid:10898529 |
| Hoffmann EK | Leukotriene D4 (LTD4) activates charybdotoxin-sensitive and -insensitive K+ channels in ehrlich ascites tumor cells. | 1999 | Pflugers Arch. | pmid:10398854 |
| Diener M and Scharrer E | The effect of short-chain fatty acids on Cl- and K+ conductance in rat colonic crypts. | 1994 | Pflugers Arch. | pmid:8052516 |
| Kawashima Y et al. | Surface-modified antiasthmatic dry powder aerosols inhaled intratracheally reduce the pharmacologically effective dose. | 1998 | Pharm. Res. | pmid:9833999 |
| Thompson MD et al. | A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha. | 2003 | Pharmacogenetics | pmid:14515063 |
| Pillai SG et al. | A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma. | 2004 | Pharmacogenetics | pmid:15475736 |
| Kagoshima M et al. | Effect of Y-24180, a long-acting antagonist to platelet-activating factor (PAF), on PAF-induced reactions: a relationship between the partial structure of the compound and its duration of the action. | 1997 | Pharmacology | pmid:9380772 |
| Lieber G et al. | Concomitant activity of histamine and cysteinyl leukotrienes on porcine nasal mucosal vessels and nasal inflammation in the rat. | 2010 | Pharmacology | pmid:20453555 |
| Takizawa T et al. | Effects of a new antiallergic agent, VUF-K-8788, on experimental asthmatic reactions in guinea pigs. | 1999 | Pharmacology | pmid:10450067 |
| Suzuki S et al. | Leukotriene D4 upregulates MUC2 gene transcription in human epithelial cells. | 2008 | Pharmacology | pmid:18176092 |
| Ro JY et al. | The inhibitory mechanism of rebamipide on the mediator release in the guinea pig lung mast cells activated with specific antigen-antibody reactions. | 2001 | Pharmacology | pmid:11598424 |
| Ishinaga H et al. | Pranlukast inhibits NF-kappaB activation and MUC2 gene expression in cultured human epithelial cells. | 2005 | Pharmacology | pmid:15475658 |
| Tokuyama K et al. | Effects of Y-27632, a Rho/Rho kinase inhibitor, on leukotriene D(4)- and histamine-induced airflow obstruction and airway microvascular leakage in guinea pigs in vivo. | 2002 | Pharmacology | pmid:11893899 |
| Xu L et al. | Involvement of cysteinyl leukotriene receptors in angiogenesis in rat thoracic aortic rings. | 2010 | Pharmazie | pmid:21105577 |
| Fukuishi N et al. | Antiallergic effect of ardisiaquinone A, a potent 5-lipoxygenase inhibitor. | 2001 | Phytomedicine | pmid:11824521 |
| Mizutani N et al. | Effect of Ganoderma lucidum on pollen-induced biphasic nasal blockage in a guinea pig model of allergic rhinitis. | 2012 | Phytother Res | pmid:21698671 |
| Smit NP et al. | Stimulation of cultured melanocytes in medium containing a serum substitute: Ultroser-G. | 1995 | Pigment Cell Res. | pmid:7540755 |
| Wienkötter N et al. | The effect of nigellone and thymoquinone on inhibiting trachea contraction and mucociliary clearance. | 2008 | Planta Med. | pmid:18219598 |
| Provost V et al. | Leukotriene D4 and interleukin-13 cooperate to increase the release of eotaxin-3 by airway epithelial cells. | 2012 | PLoS ONE | pmid:22952702 |
| Lecca D et al. | The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. | 2008 | PLoS ONE | pmid:18974869 |
| Al-Husseini A et al. | Increased eicosanoid levels in the Sugen/chronic hypoxia model of severe pulmonary hypertension. | 2015 | PLoS ONE | pmid:25785937 |
| Khaddaj-Mallat R et al. | Pro-Resolving Effects of Resolvin D2 in LTD4 and TNF-α Pre-Treated Human Bronchi. | 2016 | PLoS ONE | pmid:27935998 |
| Stelmach I et al. | [The effect of inhaled heparin on post-leukotriene bronchoconstriction in children with bronchial asthma]. | 2002 | Pol. Merkur. Lekarski | pmid:11995261 |
| Maekawa A et al. | Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18931305 |
| Habib GM et al. | Leukotriene D4 and cystinyl-bis-glycine metabolism in membrane-bound dipeptidase-deficient mice. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9560193 |
| Maekawa A et al. | GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19561298 |
| Maekawa A et al. | Identification in mice of two isoforms of the cysteinyl leukotriene 1 receptor that result from alternative splicing. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11226226 |
| Young RN | Discovery of montelukast: a once-a-day oral antagonist of leukotriene D4 for the treatment of chronic asthma. | 2001 | Prog Med Chem | pmid:11774796 |
| Rajah R et al. | Insulin-like growth factor binding protein (IGFBP) proteases: functional regulators of cell growth. | 1995 | Prog. Growth Factor Res. | pmid:8817670 |
| Shikada K and Tanaka S | Effect of the K+ channel openers NIP-121 and cromakalim on melittin-induced relaxation of guinea-pig isolated trachea. | 1996 | Prostaglandins | pmid:8792445 |
| Hisamatsu K et al. | Effect of leukotriene C4 exposure on ciliated cells of the nasal mucosa. | 1996 | Prostaglandins | pmid:8900445 |
| Kelefiotis D et al. | Eicosanoid-induced growth and signaling events in rat glomerular mesangial cells. | 1995 | Prostaglandins | pmid:7659782 |
| Nakazawa T et al. | Leukotriene D4-induced mucosal damage during long observation periods in vitro. | 1994 | Prostaglandins | pmid:8066186 |
| Ramondt J et al. | Sensitivity of ovine myometrial tissue to various eicosanoids in vitro. | 1995 | Prostaglandins | pmid:7792392 |
| Tanaka H et al. | The effect of a novel leukotriene C4/D4 antagonist, BAY-x-7195, on experimental allergic reactions. | 1995 Nov-Dec | Prostaglandins | pmid:8838238 |
| Wen FQ et al. | Eicosanoid profile in cultured human pulmonary artery smooth muscle cells treated with IL-1 beta and TNF alpha. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9758210 |
| Patry C et al. | Leukotriene receptors in HL-60 cells differentiated into eosinophils, monocytes and neutrophils. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8832765 |
| Blain JF and Sirois P | Involvement of LTD(4)in allergic pulmonary inflammation in mice: modulation by cysLT(1)antagonist MK-571. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10913229 |
| Rehni AK and Singh TG | Modulation of leukotriene D4 attenuates the development of seizures in mice. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21641195 |
| Aizawa H et al. | Thromboxane A2 antagonist inhibits leukotriene D4-induced smooth muscle contraction in guinea-pig lung parenchyma, but not in trachea. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9014223 |
| Nabe T et al. | Inhibitory effect of ONO-1078 on specific binding of peptide leukotrienes to human lung crude membrane. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7824530 |
| Yudina Y et al. | Regulation of the eicosanoid pathway by tumour necrosis factor alpha and leukotriene D4 in intestinal epithelial cells. | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19042113 |
| Inamura T et al. | Differential tissue expression of immunoreactive dehydropeptidase I, a peptidyl leukotriene metabolizing enzyme. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8171072 |
| Bochnowicz S and Underwood DC | Dose-dependent mediation of leukotriene D4-induced airway microvascular leakage and bronchoconstriction in the guinea pig. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7644563 |
| Capra V et al. | Involvement of prenylated proteins in calcium signaling induced by LTD4 in differentiated U937 cells. | 2003 | Prostaglandins Other Lipid Mediat. | pmid:14518564 |
| Claesson HE | On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma. | 2009 | Prostaglandins Other Lipid Mediat. | pmid:19130894 |
| Selg E et al. | Two different mechanisms for modulation of bronchoconstriction in guinea-pigs by cyclooxygenase metabolites. | 2009 | Prostaglandins Other Lipid Mediat. | pmid:19103301 |
| Bengtsson AM et al. | Leukotriene D(4) induces AP-1 but not NFkappaB signaling in intestinal epithelial cells. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18083053 |
| Lötzer K et al. | 5-Lipoxygenase/cyclooxygenase-2 cross-talk through cysteinyl leukotriene receptor 2 in endothelial cells. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17991613 |
| Nakanishi Y et al. | Synergism between cysteinyl leukotrienes and thromboxane A2 to induce allergic late phase nasal blockage in guinea pigs. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15560121 |
| Cui S et al. | Effects of platelet-activating factor, thromboxane A2 and leukotriene D4 on isolated perfused rat liver. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16846785 |
| Tanaka Y et al. | Different mechanisms between thromboxane A2- and leukotriene D4-induced nasal blockage in guinea pigs. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16939879 |
| Evans JF | Cysteinyl leukotriene receptors. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12432945 |
| Nishimura H et al. | Acute effects of prostaglandin D2 to induce airflow obstruction and airway microvascular leakage in guinea pigs: role of thromboxane A2 receptors. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11519790 |
| Sheller J et al. | The prostaglandin E agonist, misoprostol, inhibits airway IL-5 production in atopic asthmatics. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12428688 |
| Abraham WM et al. | Effect of TYB-2285 on antigen-induced airway responses in sheep. | 1996 | Pulm Pharmacol | pmid:8843510 |
| Joki S et al. | Effect of leukotriene D4 on ciliary activity in human, guinea-pig and rat respiratory mucosa. | 1996 | Pulm Pharmacol | pmid:9160411 |
| Callaghan DH et al. | Respiratory tract eicosanoid measurement using microdialysis sampling and GC/MS detection. | 1994 | Pulm Pharmacol | pmid:8003850 |
| Madsen F et al. | Challenge interval determines tachyphylaxis to aerosolized LTD4. | 1995 | Pulm Pharmacol | pmid:8819178 |
| Capra V and Rovati GE | Rosuvastatin inhibits human airway smooth muscle cells mitogenic response to eicosanoid contractile agents. | 2014 | Pulm Pharmacol Ther | pmid:23806820 |
| Turner DJ et al. | Bradykinin-induced airway constriction in guinea-pigs: role of leukotriene D(4). | 2000 | Pulm Pharmacol Ther | pmid:10930357 |
| Skogvall S et al. | Effects of capsazepine on human small airway responsiveness unravel a novel class of bronchorelaxants. | 2007 | Pulm Pharmacol Ther | pmid:16731017 |
| Pitt CM and Nally JE | Angiotensin II-mediated potentiation of endothelin-1-evoked bronchial contractions: a role for leukotrienes? | 1999 | Pulm Pharmacol Ther | pmid:10208831 |
| Skogvall S et al. | Discovery of a potent and long-acting bronchorelaxing capsazepinoid, RESPIR 4-95. | 2008 | Pulm Pharmacol Ther | pmid:17374498 |
| Yang XX et al. | The beta(2)-agonist salbutamol inhibits bronchoconstriction and leukotriene D(4) synthesis after dry gas hyperpnea in the guinea-pig. | 1999 | Pulm Pharmacol Ther | pmid:10545287 |
| Schelfhout V et al. | The effect of the leukotriene receptor antagonist zafirlukast on neurokinin A-induced bronchoconstriction in patients with asthma--A comparison with leukotriene D4 induced broncoconstriction. | 2008 | Pulm Pharmacol Ther | pmid:17611132 |
| Hazel BA and Kalf GF | Induction of granulocytic differentiation in myeloblasts by hydroquinone, a metabolite of benzene, involves the leukotriene D4 receptor. | 1996 | Recept Signal Transduct | pmid:8933618 |
| Nagahisa A et al. | Antiinflammatory and analgesic activity of CP-96,345: an orally active non-peptide substance P receptor antagonist. | 1993 | Regul. Pept. | pmid:7692561 |
| Beckh K et al. | Impairment of hepatic transport processes in perfused rat liver by the specific CCK receptor antagonist loxiglumide. | 1997 | Res Exp Med (Berl) | pmid:9406280 |
| McMillan JM and Jollow DJ | Macrophage enhancement of galactosamine hepatotoxicity using a rat hepatocyte culture system. | 1995 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:8564388 |
| Guan WJ et al. | Impulse oscillometry for leukotriene D4 inhalation challenge in asthma. | 2013 | Respir Care | pmid:23716710 |