| MeSH term | MeSH ID | Detail |
|---|---|---|
| Respiratory Hypersensitivity | D012130 | 18 associated lipids |
| Leukemia, Lymphocytic, Chronic, B-Cell | D015451 | 25 associated lipids |
| Otitis Media with Effusion | D010034 | 9 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Cough | D003371 | 19 associated lipids |
| Enteritis | D004751 | 8 associated lipids |
| Bronchial Hyperreactivity | D016535 | 15 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Influenza, Human | D007251 | 11 associated lipids |
| Asthma, Exercise-Induced | D001250 | 10 associated lipids |
LTD4
Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTD4?
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTD4
PubChem Associated disorders and diseases
What pathways are associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTD4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTD4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTD4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTD4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTD4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTD4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yoshisue H et al. | Cysteinyl leukotrienes synergize with growth factors to induce proliferation of human bronchial fibroblasts. | 2007 | J. Allergy Clin. Immunol. | pmid:17208594 |
| Lee KS et al. | Cysteinyl leukotriene upregulates IL-11 expression in allergic airway disease of mice. | 2007 | J. Allergy Clin. Immunol. | pmid:17208595 |
| Skogvall S et al. | Effects of capsazepine on human small airway responsiveness unravel a novel class of bronchorelaxants. | 2007 | Pulm Pharmacol Ther | pmid:16731017 |
| Kopp MV et al. | Omalizumab (Xolair) in children with seasonal allergic rhinitis: leukotriene release as a potential in vitro parameter to monitor therapeutic effects. | 2007 | Pediatr Allergy Immunol | pmid:17680911 |
| Capra V et al. | Cysteinyl-leukotrienes and their receptors in asthma and other inflammatory diseases: critical update and emerging trends. | 2007 | Med Res Rev | pmid:16894531 |
| Shirasaki H et al. | Agonist- and T(H)2 cytokine-induced up-regulation of cysteinyl leukotriene receptor messenger RNA in human monocytes. | 2007 | Ann. Allergy Asthma Immunol. | pmid:17941281 |
| Hu X et al. | [Effects of cysteinyl receptor agonist and antagonists on rat primary cortical neurons]. | 2007 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:17443896 |
| Peng F et al. | [Cysteinyl leukotriene receptor 1 antagonist pranlukast modulates differentiation of SK-N-SH cells]. | 2007 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:17443897 |
| Tokuriki S et al. | Leukotriene D(4) enhances the function of endothelin-1-primed fibroblasts. | 2007 | Clin. Immunol. | pmid:17627891 |
| Lötzer K et al. | 5-Lipoxygenase/cyclooxygenase-2 cross-talk through cysteinyl leukotriene receptor 2 in endothelial cells. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17991613 |
| Jiang Y et al. | CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells. | 2007 | Blood | pmid:17693579 |
| Peres CM et al. | Specific leukotriene receptors couple to distinct G proteins to effect stimulation of alveolar macrophage host defense functions. | 2007 | J. Immunol. | pmid:17911632 |
| Yang YY et al. | Effect of chronic CB1 cannabinoid receptor antagonism on livers of rats with biliary cirrhosis. | 2007 | Clin. Sci. | pmid:17176248 |
| Bai CH et al. | The inhibitory effect of the leukotriene receptor antagonist on leukotriene D4-induced MUC2/5AC gene expression and mucin secretion in human airway epithelial cells. | 2007 | Auris Nasus Larynx | pmid:17223000 |
| Chiba Y et al. | Impaired norepinephrine-mediated contraction of isolated nasal mucosa in guinea pigs with allergic rhinitis. | 2006 Jul-Aug | Am J Rhinol | pmid:16955783 |
| Rovati GE et al. | Cysteinyl-leukotrienes in the regulation of beta2-adrenoceptor function: an in vitro model of asthma. | 2006 | Respir. Res. | pmid:16875498 |
| Lamoureux J et al. | Leukotriene D4 enhances immunoglobulin production in CD40-activated human B lymphocytes. | 2006 | J. Allergy Clin. Immunol. | pmid:16630953 |
| Guo HF and Zhong Y | Requirement of Akt to mediate long-term synaptic depression in Drosophila. | 2006 | J. Neurosci. | pmid:16611817 |
| Ravasi S et al. | CysLT1 receptor-induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1/2 phosphorylation. | 2006 | Respir. Res. | pmid:16553950 |
| Bouchelouche K and Bouchelouche P | Cysteinyl leukotriene D4 increases human detrusor muscle responsiveness to histamine. | 2006 | J. Urol. | pmid:16753444 |