LTD4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTD4?

LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTD4

MeSH term MeSH ID Detail
Respiratory Hypersensitivity D012130 18 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Otitis Media with Effusion D010034 9 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Cough D003371 19 associated lipids
Enteritis D004751 8 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Carotid Stenosis D016893 15 associated lipids
Influenza, Human D007251 11 associated lipids
Asthma, Exercise-Induced D001250 10 associated lipids
Per page 10 20 50 | Total 39

PubChem Associated disorders and diseases

What pathways are associated with LTD4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTD4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with LTD4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTD4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with LTD4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTD4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTD4

Download all related citations
Per page 10 20 50 100 | Total 640
Authors Title Published Journal PubMed Link
Mehta KA et al. Effect of formulation and process variables on porosity parameters and release rates from a multi unit erosion matrix of a poorly soluble drug. 2000 J Control Release pmid:10640593
Ahmed T et al. Inhibition of allergic late airway responses by inhaled heparin-derived oligosaccharides. 2000 J. Appl. Physiol. pmid:10797135
Thivierge M et al. IL-5 up-regulates cysteinyl leukotriene 1 receptor expression in HL-60 cells differentiated into eosinophils. 2000 J. Immunol. pmid:11046055
Ravasi S et al. A kinetic binding study to evaluate the pharmacological profile of a specific leukotriene C(4) binding site not coupled to contraction in human lung parenchyma. 2000 Mol. Pharmacol. pmid:10825389
Hasday JD et al. Anti-inflammatory effects of zileuton in a subpopulation of allergic asthmatics. 2000 Am. J. Respir. Crit. Care Med. pmid:10764316
Hisamatsu K and Nakajima M Pranlukast protects leukotriene C4- and D4-induced epithelial cell impairment of the nasal mucosa in vitro. 2000 Life Sci. pmid:11105993
Nothacker HP et al. Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist. 2000 Mol. Pharmacol. pmid:11093801
Heise CE et al. Characterization of the human cysteinyl leukotriene 2 receptor. 2000 J. Biol. Chem. pmid:10851239
Yamashita T and Kokubun S Nonselective cationic currents activated by acetylcholine in swine tracheal smooth muscle cells. 1999 Can. J. Physiol. Pharmacol. pmid:10588484
Lärfars G et al. Activation of nitric oxide release and oxidative metabolism by leukotrienes B4, C4, and D4 in human polymorphonuclear leukocytes. 1999 Blood pmid:9949184
Habib GM and Lieberman MW Cleavage of leukotriene D4 in mice with targeted disruption of a membrane-bound dipeptidase gene. 1999 Adv. Exp. Med. Biol. pmid:10667344
Capra V et al. Evaluation of the pharmacological activity of the pure cysteinyl-leukotriene receptor antagonists CGP 45715A (iralukast) and CGP 57698 in human airways. 1999 Adv. Exp. Med. Biol. pmid:10667347
Lankisch TO et al. High-affinity cholecystokinin type A receptor/cytosolic phospholipase A2 pathways mediate Ca2+ oscillations via a positive feedback regulation by calmodulin kinase in pancreatic acini. 1999 Eur. J. Cell Biol. pmid:10535305
Sarau HM et al. Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. 1999 Mol. Pharmacol. pmid:10462554
Lynch KR et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. 1999 Nature pmid:10391245
Busse WW et al. Leukotriene pathway inhibitors in asthma and chronic obstructive pulmonary disease. 1999 Clin. Exp. Allergy pmid:10421833
Han HJ et al. Leukotriene D4 inhibits Na+ uptake through cAMP and PLC pathways in primary cultured renal proximal tubular cells. 1999 Kidney Blood Press. Res. pmid:10394108
Hoffmann EK Leukotriene D4 (LTD4) activates charybdotoxin-sensitive and -insensitive K+ channels in ehrlich ascites tumor cells. 1999 Pflugers Arch. pmid:10398854
Mulder A et al. Effect of inhaled leukotriene D4 on airway eosinophilia and airway hyperresponsiveness in asthmatic subjects. 1999 Am. J. Respir. Crit. Care Med. pmid:10228127
Pitt CM and Nally JE Angiotensin II-mediated potentiation of endothelin-1-evoked bronchial contractions: a role for leukotrienes? 1999 Pulm Pharmacol Ther pmid:10208831
Bannenberg G et al. Leukotriene C4 is a tight-binding inhibitor of microsomal glutathione transferase-1. Effects of leukotriene pathway modifiers. 1999 J. Biol. Chem. pmid:9890956
Sermasi E et al. Long term depression is expressed during postnatal development in rat visual cortex: a role for visual experience. 1999 Brain Res. Dev. Brain Res. pmid:10064875
Olszewski MA et al. Mediators of anaphylaxis but not activated neutrophils augment cholinergic responses of equine small airways. 1999 Am. J. Physiol. pmid:10070118
White IJ et al. A continuous fluorometric assay for leukotriene D4 hydrolase. 1999 Anal. Biochem. pmid:10075814
Takami M and Tsukada W Effect of DP-1904, a thromboxane synthetase inhibitor, on antigen- and spasmogen-induced bronchoconstriction in rodents. 1999 Eur. J. Pharmacol. pmid:10082207
Yang XX et al. The beta(2)-agonist salbutamol inhibits bronchoconstriction and leukotriene D(4) synthesis after dry gas hyperpnea in the guinea-pig. 1999 Pulm Pharmacol Ther pmid:10545287
Olszewski MA et al. Pre- and postjunctional effects of inflammatory mediators in horse airways. 1999 Am. J. Physiol. pmid:10444527
Takizawa T et al. Effects of a new antiallergic agent, VUF-K-8788, on experimental asthmatic reactions in guinea pigs. 1999 Pharmacology pmid:10450067
Yang XX et al. Strain dependence of the airway response to dry-gas hyperpnea challenge in the rat. 1999 J. Appl. Physiol. pmid:9887125
Sciuto AM et al. Post-exposure treatment with isoproterenol attenuates pulmonary edema in phosgene-exposed rabbits. 1998 Sep-Oct J Appl Toxicol pmid:9804432
Cho JS et al. The effect of leukotriene D4 on the patency of nasal passage in the guinea pig. 1998 Nov-Dec Am J Rhinol pmid:9883299
Wen FQ et al. Eicosanoid profile in cultured human pulmonary artery smooth muscle cells treated with IL-1 beta and TNF alpha. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9758210
Francis HP et al. The effects of a novel sulphidopeptide leukotriene antagonist, BAY x7195, against elicited bronchoconstriction in the anaesthetized guinea-pig. 1998 Br. J. Pharmacol. pmid:9484852
Ohbayashi H et al. Compared effects of natriuretic peptides on ovalbumin-induced asthmatic model. 1998 Eur. J. Pharmacol. pmid:9617752
Kohno S [Role of peptide-leukotrienes in bronchial asthma]. 1998 Nippon Yakurigaku Zasshi pmid:9618707
Cyrus CB et al. Leukotrienes C4 and D4 increase the ciliary beat frequency in human upper airway mucosa in vitro. 1998 Otolaryngol Head Neck Surg pmid:9560097
von Sprecher A et al. Synthesis and SAR of a novel, potent and structurally simple LTD4 antagonist of the quinoline class. 1998 Bioorg. Med. Chem. Lett. pmid:9871521
Dahlén B et al. Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics. 1998 Am. J. Respir. Crit. Care Med. pmid:9563738
Capra V et al. Pharmacological characterization of the cysteinyl-leukotriene antagonists CGP 45715A (iralukast) and CGP 57698 in human airways in vitro. 1998 Br. J. Pharmacol. pmid:9504401
Venugopalan CS et al. Responses of guinea-pig lung parenchymal strips to tracheobronchial lavage fluid from horses affected with summer pasture-associated obstructive pulmonary disease. 1998 Vet. Res. Commun. pmid:9868763
Chambers RJ et al. Development of new chromanol antagonists of leukotriene D4. 1998 Bioorg. Med. Chem. Lett. pmid:9873435
Nagayama S et al. Increased sensitivity to vincristine of MDR cells by the leukotriene D4 receptor antagonist, ONO-1078. 1998 Cancer Lett. pmid:9751271
Geirsson A et al. Potentiating effects of pertussis toxin on leukotriene C4 induced formation of inositol phosphate and prostacyclin in human umbilical vein endothelial cells. 1998 J. Cell. Physiol. pmid:9731750
Kim N et al. Leukotriene D4-induced contraction of cat esophageal and lower esophageal sphincter circular smooth muscle. 1998 Gastroenterology pmid:9753495
Grönroos E et al. Leukotriene D4 induces a rapid increase in cAMP in the human epithelial cell line, Int 407: a potential role for this signal in the regulation of calcium influx through the plasma membrane. 1998 Cell Calcium pmid:9793684
Tsang F et al. Effects of mitogen-activated protein kinase kinase inhibitor PD 098059 on antigen challenge of guinea-pig airways in vitro. 1998 Br. J. Pharmacol. pmid:9776345
Panettieri RA et al. Effects of LTD4 on human airway smooth muscle cell proliferation, matrix expression, and contraction In vitro: differential sensitivity to cysteinyl leukotriene receptor antagonists. 1998 Am. J. Respir. Cell Mol. Biol. pmid:9730873
Lane SJ Leukotriene antagonism in asthma and rhinitis. 1998 Respir Med pmid:9850362
Traianedes K et al. 5-Lipoxygenase metabolites inhibit bone formation in vitro. 1998 Endocrinology pmid:9645691
Jonsson EW Functional characterisation of receptors for cysteinyl leukotrienes in smooth muscle. 1998 Acta Physiol Scand Suppl pmid:9597121