| MeSH term | MeSH ID | Detail |
|---|---|---|
| Stomach Ulcer | D013276 | 75 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
LTD4
Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTD4?
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTD4
PubChem Associated disorders and diseases
What pathways are associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTD4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTD4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTD4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTD4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTD4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTD4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Javed NH et al. | Enhanced tissue responsiveness in colonic ion transport of cow's milk-sensitized guinea pigs. | 1994 | Agents Actions | pmid:7521569 |
| Dandurand RJ et al. | In vitro allergic bronchoconstriction in the brown Norway rat. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:8004305 |
| Underwood DC et al. | Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs. | 1994 | J. Pharmacol. Exp. Ther. | pmid:8035322 |
| Mion F et al. | Short term effects of indomethacin on rat small intestinal permeability. Role of eicosanoids and platelet activating factor. | 1994 | Gut | pmid:8174986 |
| Salari H et al. | Involvement of immunologic mechanisms in a guinea pig model of western red cedar asthma. | 1994 | J. Allergy Clin. Immunol. | pmid:8182231 |
| Sanz ML et al. | Modulation of beta 2-adrenoceptors in human lymphocytes by in vitro stimulation with mediators. | 1994 May-Jun | J Investig Allergol Clin Immunol | pmid:7526943 |
| Furukawa K et al. | Simplified sulfidoleukotriene ELISA using LTD4-conjugated phosphatase for the study of allergen-induced leukotriene generation by isolated mononuclear cells and diluted whole blood. | 1994 May-Jun | J Investig Allergol Clin Immunol | pmid:7981880 |
| Goldhill JM et al. | Neural control of mouse small intestinal longitudinal muscle: interactions with inflammatory mediators. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7616450 |
| Jones TR et al. | Pharmacology of montelukast sodium (Singulair), a potent and selective leukotriene D4 receptor antagonist. | 1995 | Can. J. Physiol. Pharmacol. | pmid:7621356 |
| Grönroos E et al. | The regulation of leukotriene D4-induced calcium influx in human epithelial cells involves protein tyrosine phosphorylation. | 1995 | Cell Calcium | pmid:7621531 |
| Tanaka T et al. | Effect of oxatomide on otitis media with effusion--an experimental study. | 1995 | Acta Otolaryngol. | pmid:7572131 |
| Ganbo T et al. | Effect of ibudilast on ciliary activity of human paranasal sinus mucosa in vitro. | 1995 | Arzneimittelforschung | pmid:7575753 |
| Donnelly AL et al. | The leukotriene D4-receptor antagonist, ICI 204,219, relieves symptoms of acute seasonal allergic rhinitis. | 1995 | Am. J. Respir. Crit. Care Med. | pmid:7767514 |
| Bochnowicz S and Underwood DC | Dose-dependent mediation of leukotriene D4-induced airway microvascular leakage and bronchoconstriction in the guinea pig. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7644563 |
| Weiss SR et al. | Quenching: inhibition of development and expression of amygdala kindled seizures with low frequency stimulation. | 1995 | Neuroreport | pmid:8595196 |
| Tasaka K et al. | Effect of loratadine on immediate and delayed type hypersensitivity reactions. | 1995 | Arzneimittelforschung | pmid:8573225 |
| Tudoric N et al. | Effects of halothane and isoflurane on antigen- and leukotriene-D4-induced constriction of guinea pig trachea. | 1995 | Acta Anaesthesiol Scand | pmid:8607320 |
| Ortiz JL et al. | Leukotriene receptors on human pulmonary vascular endothelium. | 1995 | Br. J. Pharmacol. | pmid:8564195 |
| McMillan JM and Jollow DJ | Macrophage enhancement of galactosamine hepatotoxicity using a rat hepatocyte culture system. | 1995 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:8564388 |
| Bonnefoi MS et al. | Subchronic toxicity studies with the leukotriene D4 antagonist RG 12525. | 1995 | Fundam Appl Toxicol | pmid:8566477 |