| MeSH term | MeSH ID | Detail |
|---|---|---|
| Endotoxemia | D019446 | 27 associated lipids |
| Respirovirus Infections | D010253 | 3 associated lipids |
| Neuralgia | D009437 | 28 associated lipids |
| Sneezing | D012912 | 6 associated lipids |
| Peptic Ulcer Hemorrhage | D010438 | 4 associated lipids |
| Nasal Obstruction | D015508 | 4 associated lipids |
| Respiratory Syncytial Virus Infections | D018357 | 10 associated lipids |
| Asbestosis | D001195 | 8 associated lipids |
| Aspergillosis, Allergic Bronchopulmonary | D001229 | 2 associated lipids |
LTD4
Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTD4?
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTD4
PubChem Associated disorders and diseases
What pathways are associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTD4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTD4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTD4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTD4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTD4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTD4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chong K et al. | Drug substance manufacture process control: application of flow injection analysis and HPLC for monitoring an enantiospecific synthesis. | 1996 | J Pharm Biomed Anal | pmid:8895082 |
| Nakamura S et al. | Effects of 1-[3-(4-benzhydryl-1-piperazinyl)propyl]-3- (1H-imidazol-1-ylmethyl)-1H-indole-6-carboxylic acid with thromboxane A2 synthetase inhibitory and H1-blocking activities on anaphylactic bronchospasm. | 1996 | Arzneimittelforschung | pmid:8955866 |
| Joki S et al. | Effect of leukotriene D4 on ciliary activity in human, guinea-pig and rat respiratory mucosa. | 1996 | Pulm Pharmacol | pmid:9160411 |
| Tanaka H et al. | The effect of a novel leukotriene C4/D4 antagonist, BAY-x-7195, on experimental allergic reactions. | 1995 Nov-Dec | Prostaglandins | pmid:8838238 |
| Georgitis JW et al. | Chronic sinusitis: characterization of cellular influx and inflammatory mediators in sinus lavage fluid. | 1995 | Int. Arch. Allergy Immunol. | pmid:7719157 |
| Szarek JL and Valentovic MA | Release of prostaglandin E2 and leukotriene C4/D4 from airway segments isolated from rats after exposure to ozone for 20 months. | 1995 | Toxicology | pmid:7624868 |
| Conroy DM et al. | Relaxant effects of pituitary adenylate cyclase activating polypeptide (PACAP) on epithelium-intact and -denuded guinea-pig trachea: a comparison with vasoactive intestinal peptide (VIP). | 1995 | Neuropeptides | pmid:8538872 |
| Howell RE et al. | Pulmonary pharmacology of WAY-126299A: a dual-acting 5-lipoxygenase inhibitor and leukotriene D4 antagonist. | 1995 | Inflamm. Res. | pmid:8548382 |
| Chen C et al. | Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC gamma mutant mice. | 1995 | Cell | pmid:8548809 |
| Takami M et al. | Possible role of thromboxane A2 in hyperresponsiveness of isolated rat lung tissue in a Sephadex-induced eosinophilia model. | 1995 | Int. Arch. Allergy Immunol. | pmid:7536504 |
| Goldhill JM et al. | Neural control of mouse small intestinal longitudinal muscle: interactions with inflammatory mediators. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7616450 |
| Jones TR et al. | Pharmacology of montelukast sodium (Singulair), a potent and selective leukotriene D4 receptor antagonist. | 1995 | Can. J. Physiol. Pharmacol. | pmid:7621356 |
| Grönroos E et al. | The regulation of leukotriene D4-induced calcium influx in human epithelial cells involves protein tyrosine phosphorylation. | 1995 | Cell Calcium | pmid:7621531 |
| Tanaka T et al. | Effect of oxatomide on otitis media with effusion--an experimental study. | 1995 | Acta Otolaryngol. | pmid:7572131 |
| Ganbo T et al. | Effect of ibudilast on ciliary activity of human paranasal sinus mucosa in vitro. | 1995 | Arzneimittelforschung | pmid:7575753 |
| Aida Y et al. | The antagonistic effects of khellactones on platelet-activating factor, histamine, and leukotriene D4. | 1995 | Chem. Pharm. Bull. | pmid:7553972 |
| Wettstein M et al. | Metabolism of cysteinyl leukotrienes in the perfused rat liver: the influence of endotoxin pretreatment and the cellular hydration state. | 1995 | Hepatology | pmid:7601416 |
| Meier HL et al. | Simultaneous initiation of degranulation and inhibition of leukotriene release by soman in human basophils. | 1995 | Int. J. Immunopharmacol. | pmid:7545649 |
| Nagase T et al. | In vitro airway and tissue response to antigen in sensitized rats. Role of serotonin and leukotriene D4. | 1995 | Am. J. Respir. Crit. Care Med. | pmid:7599867 |
| Porreca E et al. | Modulation of rat vascular smooth muscle cell (VSMC) proliferation by cysteinyl leukotriene D4: a role for mediation of interleukin 1. | 1995 | Atherosclerosis | pmid:7755646 |
| Hazel BA et al. | Benzene and its metabolite, hydroquinone, induce granulocytic differentiation in myeloblasts by interacting with cellular signaling pathways activated by granulocyte colony-stimulating factor. | 1995 | Stem Cells | pmid:7542115 |
| Cohen P et al. | Leukotriene D4 facilitates airway smooth muscle cell proliferation via modulation of the IGF axis. | 1995 | Am. J. Physiol. | pmid:7544535 |
| Zhang MQ et al. | (Piperidinylalkoxy)chromones: novel antihistamines with additional antagonistic activity against leukotriene D4. | 1995 | J. Med. Chem. | pmid:7608912 |
| Nasuhara Y et al. | [Acyclovir and guinea-pig airway smooth muscle]. | 1995 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:7563998 |
| Iwamoto I et al. | Effect of a selective thromboxane A2 receptor antagonist BAY u3405 on antigen-, leukotriene C4- and leukotriene D4-induced bronchoconstriction in guinea pigs. | 1995 | Int. Arch. Allergy Immunol. | pmid:7647588 |
| Patel JP et al. | Beneficial effects of combined thromboxane and leukotriene receptor antagonism in hemorrhagic shock. | 1995 | Crit. Care Med. | pmid:7867347 |
| Kelefiotis D et al. | Eicosanoid-induced growth and signaling events in rat glomerular mesangial cells. | 1995 | Prostaglandins | pmid:7659782 |
| Donnelly AL et al. | The leukotriene D4-receptor antagonist, ICI 204,219, relieves symptoms of acute seasonal allergic rhinitis. | 1995 | Am. J. Respir. Crit. Care Med. | pmid:7767514 |
| Smit NP et al. | Stimulation of cultured melanocytes in medium containing a serum substitute: Ultroser-G. | 1995 | Pigment Cell Res. | pmid:7540755 |
| Tanaka T et al. | Protective effect of peptide leukotriene antagonist on renal failure induced by a tourniquet in rabbits. | 1995 | Forensic Sci. Int. | pmid:7875619 |
| Ganbo T et al. | Inhibition of mucociliary clearance of the eustachian tube by leukotrienes C4 and D4. | 1995 | Ann. Otol. Rhinol. Laryngol. | pmid:7872607 |
| Kanwar S et al. | Leukotriene C4/D4 induces P-selectin and sialyl Lewis(x)-dependent alterations in leukocyte kinetics in vivo. | 1995 | Circ. Res. | pmid:7554141 |
| Fiorucci S et al. | Effect of NSAIDs on pepsinogen secretion and calcium mobilization in isolated chief cells. | 1995 | Am. J. Physiol. | pmid:7611418 |
| Datta YH et al. | Peptido-leukotrienes are potent agonists of von Willebrand factor secretion and P-selectin surface expression in human umbilical vein endothelial cells. | 1995 | Circulation | pmid:7586318 |
| Ramondt J et al. | Sensitivity of ovine myometrial tissue to various eicosanoids in vitro. | 1995 | Prostaglandins | pmid:7792392 |
| Herron DK et al. | Visualization and comparison of molecular dynamics simulations of leukotriene C4, leukotriene D4, and leukotriene E4. | 1995 | J Mol Graph | pmid:8820302 |
| Gorenne I et al. | Antagonism of leukotriene responses in human airways by BAY x7195. | 1995 | Eur. J. Pharmacol. | pmid:7796856 |
| Powell WS et al. | Effects of dexamethasone on leukotriene synthesis and airway responses to antigen and leukotriene D4 in rats. | 1995 | Am. J. Respir. Crit. Care Med. | pmid:7697244 |
| Wasserman MA et al. | Synergism exhibited by LTD4 and PAF receptor antagonists in decreasing antigen-induced airway microvascular leakage. | 1995 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7732851 |
| Gronert K et al. | Endogenous sulfidopeptide leukotriene synthesis and 12-lipoxygenase activity in bullfrog (Rana catesbeiana) erythrocytes. | 1995 | Biochim. Biophys. Acta | pmid:7734448 |
| Porreca E et al. | Cysteinyl-leukotriene D4 induced IL-1 beta expression and release in rat vascular smooth muscle cells. | 1995 | Atherosclerosis | pmid:7661877 |
| Ganbo T et al. | The effects of leukotrienes C4 and D4 on ciliary activity of human paranasal sinus mucosa in vitro. | 1995 | Rhinology | pmid:8919211 |
| Tasaka K et al. | Effect of loratadine on immediate and delayed type hypersensitivity reactions. | 1995 | Arzneimittelforschung | pmid:8573225 |
| Tudoric N et al. | Effects of halothane and isoflurane on antigen- and leukotriene-D4-induced constriction of guinea pig trachea. | 1995 | Acta Anaesthesiol Scand | pmid:8607320 |
| Ortiz JL et al. | Leukotriene receptors on human pulmonary vascular endothelium. | 1995 | Br. J. Pharmacol. | pmid:8564195 |
| McMillan JM and Jollow DJ | Macrophage enhancement of galactosamine hepatotoxicity using a rat hepatocyte culture system. | 1995 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:8564388 |
| Bonnefoi MS et al. | Subchronic toxicity studies with the leukotriene D4 antagonist RG 12525. | 1995 | Fundam Appl Toxicol | pmid:8566477 |
| Wood-Baker R et al. | The reproducibility and effect on non-specific airway responsiveness of inhaled prostaglandin D2 and leukotriene D4 in asthmatic subjects. | 1995 | Br J Clin Pharmacol | pmid:7742148 |
| Rajah R et al. | Insulin-like growth factor binding protein (IGFBP) proteases: functional regulators of cell growth. | 1995 | Prog. Growth Factor Res. | pmid:8817670 |
| Madsen F et al. | Challenge interval determines tachyphylaxis to aerosolized LTD4. | 1995 | Pulm Pharmacol | pmid:8819178 |