| MeSH term | MeSH ID | Detail |
|---|---|---|
| Endotoxemia | D019446 | 27 associated lipids |
| Respirovirus Infections | D010253 | 3 associated lipids |
| Neuralgia | D009437 | 28 associated lipids |
| Sneezing | D012912 | 6 associated lipids |
| Peptic Ulcer Hemorrhage | D010438 | 4 associated lipids |
| Nasal Obstruction | D015508 | 4 associated lipids |
| Respiratory Syncytial Virus Infections | D018357 | 10 associated lipids |
| Asbestosis | D001195 | 8 associated lipids |
| Aspergillosis, Allergic Bronchopulmonary | D001229 | 2 associated lipids |
LTD4
Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTD4?
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTD4
PubChem Associated disorders and diseases
What pathways are associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTD4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTD4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTD4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTD4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTD4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTD4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Adolfsson JL et al. | Leukotriene D4-induced activation and translocation of the G-protein alpha i3-subunit in human epithelial cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8806649 |
| Wang ML et al. | Leukotriene D4 induces brain edema and enhances CysLT2 receptor-mediated aquaporin 4 expression. | 2006 | Biochem. Biophys. Res. Commun. | pmid:17010308 |
| Tada N et al. | Experimental otitis media with effusion induced by leukotriene D4. | 2002 | Auris Nasus Larynx | pmid:11893446 |
| Chiba Y et al. | Regional differences in vascular responsiveness of nasal mucosae isolated from naive guinea pigs. | 2007 | Auris Nasus Larynx | pmid:17056219 |
| Bai CH et al. | The inhibitory effect of the leukotriene receptor antagonist on leukotriene D4-induced MUC2/5AC gene expression and mucin secretion in human airway epithelial cells. | 2007 | Auris Nasus Larynx | pmid:17223000 |
| Porreca E et al. | Modulation of rat vascular smooth muscle cell (VSMC) proliferation by cysteinyl leukotriene D4: a role for mediation of interleukin 1. | 1995 | Atherosclerosis | pmid:7755646 |
| Porreca E et al. | Cysteinyl-leukotriene D4 induced IL-1 beta expression and release in rat vascular smooth muscle cells. | 1995 | Atherosclerosis | pmid:7661877 |
| Kumasawa F et al. | Mitogen-activated protein kinase (MAPK) regulates leukotriene D4-induced HB-EGF and ADAM12 expression in human airway smooth muscle cells. | 2013 | Asian Pac. J. Allergy Immunol. | pmid:23517395 |
| Nakamura S et al. | Effects of 1-[3-(4-benzhydryl-1-piperazinyl)propyl]-3- (1H-imidazol-1-ylmethyl)-1H-indole-6-carboxylic acid with thromboxane A2 synthetase inhibitory and H1-blocking activities on anaphylactic bronchospasm. | 1996 | Arzneimittelforschung | pmid:8955866 |
| Tasaka K et al. | Effect of loratadine on immediate and delayed type hypersensitivity reactions. | 1995 | Arzneimittelforschung | pmid:8573225 |