LTD4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTD4?

LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTD4

MeSH term MeSH ID Detail
Endotoxemia D019446 27 associated lipids
Respirovirus Infections D010253 3 associated lipids
Neuralgia D009437 28 associated lipids
Sneezing D012912 6 associated lipids
Peptic Ulcer Hemorrhage D010438 4 associated lipids
Nasal Obstruction D015508 4 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Asbestosis D001195 8 associated lipids
Aspergillosis, Allergic Bronchopulmonary D001229 2 associated lipids
Per page 10 20 50 | Total 39

PubChem Associated disorders and diseases

What pathways are associated with LTD4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTD4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with LTD4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTD4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with LTD4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTD4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTD4

Download all related citations
Per page 10 20 50 100 | Total 640
Authors Title Published Journal PubMed Link
Huang XQ et al. Transforming growth factor β1-induced astrocyte migration is mediated in part by activating 5-lipoxygenase and cysteinyl leukotriene receptor 1. 2012 J Neuroinflammation pmid:22734808
Ramis I et al. Application of totally automated on-line sample clean up system for extraction and high-performance liquid chromatography separation of peptide leukotrienes. 1993 Nov-Dec J Pharm Biomed Anal pmid:8123725
Chong K et al. Drug substance manufacture process control: application of flow injection analysis and HPLC for monitoring an enantiospecific synthesis. 1996 J Pharm Biomed Anal pmid:8895082
Syslová K et al. Immunomagnetic molecular probe with UHPLC-MS/MS: a promising way for reliable bronchial asthma diagnostics based on quantification of cysteinyl leukotrienes. 2013 Jul-Aug J Pharm Biomed Anal pmid:23644905
Carlton RA et al. Preparation and characterization of polymorphs for an LTD4 antagonist, RG 12525. 1996 J Pharm Sci pmid:8742935
Shimoda H et al. Anti type I allergic property of Japanese butterbur extract and its mast cell degranulation inhibitory ingredients. 2006 J. Agric. Food Chem. pmid:16608208
Kondeti V et al. Leukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3. 2016 J. Allergy Clin. Immunol. pmid:26255103
Reiss TF et al. Effects of montelukast (MK-0476), a new potent cysteinyl leukotriene (LTD4) receptor antagonist, in patients with chronic asthma. 1996 J. Allergy Clin. Immunol. pmid:8828530
Woszczek G et al. Leukotriene D(4) induces gene expression in human monocytes through cysteinyl leukotriene type I receptor. 2008 J. Allergy Clin. Immunol. pmid:18028998
Espinosa K et al. CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4. 2003 J. Allergy Clin. Immunol. pmid:12743568
Parmentier CN et al. Human T(H)2 cells respond to cysteinyl leukotrienes through selective expression of cysteinyl leukotriene receptor 1. 2012 J. Allergy Clin. Immunol. pmid:22391114
Crimi N et al. Inhibitory effect of a leukotriene receptor antagonist (montelukast) on neurokinin A-induced bronchoconstriction. 2003 J. Allergy Clin. Immunol. pmid:12704366
Peters SP Leukotriene receptor antagonists in asthma therapy. 2003 J. Allergy Clin. Immunol. pmid:12532087
Doherty TA et al. Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production. 2013 J. Allergy Clin. Immunol. pmid:23688412
Guan W et al. Leukotriene D4 and methacholine bronchial provocation tests for identifying leukotriene-responsiveness subtypes. 2013 J. Allergy Clin. Immunol. pmid:23040886
Thivierge M et al. Toll-like receptor agonists differentially regulate cysteinyl-leukotriene receptor 1 expression and function in human dendritic cells. 2006 J. Allergy Clin. Immunol. pmid:16675346
Kawano T et al. Cysteinyl leukotrienes induce nuclear factor kappa b activation and RANTES production in a murine model of asthma. 2003 J. Allergy Clin. Immunol. pmid:12897744
Yoshisue H et al. Cysteinyl leukotrienes synergize with growth factors to induce proliferation of human bronchial fibroblasts. 2007 J. Allergy Clin. Immunol. pmid:17208594
Lee KS et al. Cysteinyl leukotriene upregulates IL-11 expression in allergic airway disease of mice. 2007 J. Allergy Clin. Immunol. pmid:17208595
Lee TH et al. Leukotriene E4: perspective on the forgotten mediator. 2009 J. Allergy Clin. Immunol. pmid:19482346
Austen KF et al. The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications. 2009 J. Allergy Clin. Immunol. pmid:19647860
Asakura T et al. Leukotriene D4 stimulates collagen production from myofibroblasts transformed by TGF-beta. 2004 J. Allergy Clin. Immunol. pmid:15316508
Rael E Unraveling the complexity of leukotriene and prostaglandin inflammatory signaling. 2016 J. Allergy Clin. Immunol. pmid:26518091
Gyllfors P et al. Bronchial responsiveness to leukotriene D4 is resistant to inhaled fluticasone propionate. 2006 J. Allergy Clin. Immunol. pmid:16815141
Braccioni F et al. The effect of cysteinyl leukotrienes on growth of eosinophil progenitors from peripheral blood and bone marrow of atopic subjects. 2002 J. Allergy Clin. Immunol. pmid:12110827
Bandeira-Melo C et al. Cysteinyl leukotrienes induce IL-4 release from cord blood-derived human eosinophils. 2002 J. Allergy Clin. Immunol. pmid:12063527
Bochner BS and Busse WW Allergy and asthma. 2005 J. Allergy Clin. Immunol. pmid:15867851
Gauvreau GM et al. Expression of functional cysteinyl leukotriene receptors by human basophils. 2005 J. Allergy Clin. Immunol. pmid:15990778
Salari H et al. Involvement of immunologic mechanisms in a guinea pig model of western red cedar asthma. 1994 J. Allergy Clin. Immunol. pmid:8182231
Lamoureux J et al. Leukotriene D4 enhances immunoglobulin production in CD40-activated human B lymphocytes. 2006 J. Allergy Clin. Immunol. pmid:16630953
Nagata M et al. Leukotriene D4 upregulates eosinophil adhesion via the cysteinyl leukotriene 1 receptor. 2002 J. Allergy Clin. Immunol. pmid:11941318
Ahmed T et al. Inhibition of allergic late airway responses by inhaled heparin-derived oligosaccharides. 2000 J. Appl. Physiol. pmid:10797135
Omori C et al. Eicosanoids modulate hyperpnea-induced bronchoconstriction in canine peripheral airways. 1996 J. Appl. Physiol. pmid:8889761
Nagase T et al. Airway and tissue behavior during early response in sensitized rats: role of 5-HT and LTD4. 1996 J. Appl. Physiol. pmid:8929602
Yang XX et al. Strain dependence of the airway response to dry-gas hyperpnea challenge in the rat. 1999 J. Appl. Physiol. pmid:9887125
Kimura K et al. Modulation of platelet activating factor-induced glycogenolysis in the perfused rat liver after administration of endotoxin in vivo. 1998 J. Biochem. pmid:9504421
McMahon B et al. Lipoxin A4 antagonizes the mitogenic effects of leukotriene D4 in human renal mesangial cells. Differential activation of MAP kinases through distinct receptors. 2000 J. Biol. Chem. pmid:10869343
Maekawa A et al. Targeted gene disruption reveals the role of cysteinyl leukotriene 1 receptor in the enhanced vascular permeability of mice undergoing acute inflammatory responses. 2002 J. Biol. Chem. pmid:11932261
Thodeti CK et al. Leukotriene D(4) triggers an association between gbetagamma subunits and phospholipase C-gamma1 in intestinal epithelial cells. 2000 J. Biol. Chem. pmid:10734140
Hoshino M et al. Leukotriene D4 activates mitogen-activated protein kinase through a protein kinase Calpha-Raf-1-dependent pathway in human monocytic leukemia THP-1 cells. 1998 J. Biol. Chem. pmid:9478929
Leier I et al. The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. 1994 J. Biol. Chem. pmid:7961706
Kanaoka Y et al. Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand. 2013 J. Biol. Chem. pmid:23504326
Bukiya AN et al. Activation of calcium- and voltage-gated potassium channels of large conductance by leukotriene B4. 2014 J. Biol. Chem. pmid:25371198
Naik S et al. Regulation of cysteinyl leukotriene type 1 receptor internalization and signaling. 2005 J. Biol. Chem. pmid:15590629
Mezhybovska M et al. The inflammatory mediator leukotriene D4 induces beta-catenin signaling and its association with antiapoptotic Bcl-2 in intestinal epithelial cells. 2006 J. Biol. Chem. pmid:16407243
Paruchuri S et al. The pro-inflammatory mediator leukotriene D4 induces phosphatidylinositol 3-kinase and Rac-dependent migration of intestinal epithelial cells. 2005 J. Biol. Chem. pmid:15657050
Heise CE et al. Characterization of the human cysteinyl leukotriene 2 receptor. 2000 J. Biol. Chem. pmid:10851239
Metters KM and Zamboni RJ Photoaffinity labeling of the leukotriene D4 receptor in guinea pig lung. 1993 J. Biol. Chem. pmid:8384212
Hui Y et al. The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization. 2001 J. Biol. Chem. pmid:11591709
Paruchuri S et al. Leukotriene E4 activates peroxisome proliferator-activated receptor gamma and induces prostaglandin D2 generation by human mast cells. 2008 J. Biol. Chem. pmid:18411276