LTD4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTD4?

LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTD4

MeSH term MeSH ID Detail
Aspergillosis, Allergic Bronchopulmonary D001229 2 associated lipids
Respirovirus Infections D010253 3 associated lipids
Peptic Ulcer Hemorrhage D010438 4 associated lipids
Nasal Obstruction D015508 4 associated lipids
Sneezing D012912 6 associated lipids
Enteritis D004751 8 associated lipids
Asbestosis D001195 8 associated lipids
Otitis Media with Effusion D010034 9 associated lipids
Inflammatory Bowel Diseases D015212 9 associated lipids
Rhinitis D012220 10 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTD4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTD4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTD4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTD4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTD4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTD4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTD4

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Authors Title Published Journal PubMed Link
Garcia C et al. Effects of synthetic peptido-leukotrienes on bone resorption in vitro. 1996 J. Bone Miner. Res. pmid:8992883
Rajah R et al. Leukotriene D4 induces MMP-1, which functions as an IGFBP protease in human airway smooth muscle cells. 1996 Am. J. Physiol. pmid:8997273
Pedersen S et al. Leukotriene D4-induced Ca2+ mobilization in Ehrlich ascites tumor cells. 1997 J. Membr. Biol. pmid:9002425
Brocks DR et al. The single and multiple dose pharmacokinetics of pranlukast in healthy volunteers. 1996 Eur. J. Clin. Pharmacol. pmid:9010703
Aizawa H et al. Thromboxane A2 antagonist inhibits leukotriene D4-induced smooth muscle contraction in guinea-pig lung parenchyma, but not in trachea. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:9014223
Gissurarson SR et al. Effect of lobaric acid on cysteinyl-leukotriene formation and contractile activity of guinea pig taenia coli. 1997 J. Pharmacol. Exp. Ther. pmid:9023290
Kubes P Nitric oxide and microvascular permeability: a continuing dilemma. 1997 Eur. Respir. J. pmid:9032483
Kageyama N et al. Role of endogenous nitric oxide in airway microvascular leakage induced by inflammatory mediators. 1997 Eur. Respir. J. pmid:9032485
Gorenne I et al. Antigen stimulation of human pulmonary smooth muscle: an in vitro model of inflammation. 1996 Cell Biol. Toxicol. pmid:9034615
Tvaermose-Nielsen O et al. Discovery of OT4003, a novel, potent, and orally active cys-LT1 receptor antagonist. 1997 Bioorg. Med. Chem. pmid:9061206
Wang Y et al. Induction of LTD in the dentate gyrus in vitro is NMDA receptor independent, but dependent on Ca2+ influx via low-voltage-activated Ca2+ channels and release of Ca2+ from intracellular stores. 1997 J. Neurophysiol. pmid:9065852
Dumitriu D et al. Mechanism of action of leukotriene D4 on guinea pig tracheal smooth muscle cells: roles of Ca++ influx and intracellular Ca++ release. 1997 J. Pharmacol. Exp. Ther. pmid:9067324
Joki S and Saano V Influence of ageing on ciliary beat frequency and on ciliary response to leukotriene D4 in guinea-pig tracheal epithelium. 1997 Clin. Exp. Pharmacol. Physiol. pmid:9075591
Zhang MQ and Timmerman H Leukotriene cysLT1 (LTD4) receptor antagonism of H1-antihistamines: an in vitro study. 1997 Inflamm. Res. pmid:9098782
Diamant Z et al. The effect of inhaled leukotriene D4 and methacholine on sputum cell differentials in asthma. 1997 Am. J. Respir. Crit. Care Med. pmid:9105062
Muñoz NM et al. Eosinophil chemotaxis inhibited by 5-lipoxygenase blockade and leukotriene receptor antagonism. 1997 Am. J. Respir. Crit. Care Med. pmid:9105085
Maehr H and Yang R Structure optimization of a leukotriene D4 antagonist by combinatorial chemistry in solution. 1997 Bioorg. Med. Chem. pmid:9113326
Hazel BA et al. Induction of granulocytic differentiation in a mouse model by benzene and hydroquinone. 1996 Environ. Health Perspect. pmid:9118902
Uno T et al. Participation of leukotriene D4 and tumor necrosis factor on lipopolysaccharide-induced airway hyperresponsiveness in guinea pigs. 1997 Biol. Pharm. Bull. pmid:9145204
Pedersen KE et al. Cysteinyl leukotrienes induce P-selectin expression in human endothelial cells via a non-CysLT1 receptor-mediated mechanism. 1997 J. Pharmacol. Exp. Ther. pmid:9152370
Joki S et al. Effect of leukotriene D4 on ciliary activity in human, guinea-pig and rat respiratory mucosa. 1996 Pulm Pharmacol pmid:9160411
Goldhill J et al. Interleukin-4 modulates cholinergic neural control of mouse small intestinal longitudinal muscle. 1997 Am. J. Physiol. pmid:9176223
Sakurai S et al. Synthesis and dual antagonistic activity against thromboxane A2 and leukotriene D4 of [4-[1-(benzenesulfonamido)alkyl]phenyl]alkanoic acid derivatives. 1997 Chem. Pharm. Bull. pmid:9178522
Meng XJ et al. Leukotriene D4 activates a chloride conductance in hepatocytes from lipopolysaccharide-treated rats. 1997 J. Clin. Invest. pmid:9185515
Sakurai S et al. [Synthesis and dual antagonistic activity against thromboxane A2 and leukotriene D4 of benzenesulfonamide derivatives]. 1997 Yakugaku Zasshi pmid:9194397
Sampson SE et al. Effect of inhaled prostaglandin D2 in normal and atopic subjects, and of pretreatment with leukotriene D4. 1997 Thorax pmid:9227716
O'Shaughnessy TC et al. Effect of pranlukast, an oral leukotriene receptor antagonist, on leukotriene D4 (LTD4) challenge in normal volunteers. 1997 Thorax pmid:9227717
Honda I et al. Tachykinin antagonist FK224 inhibits neurokinin A-, substance P- and capsaicin-induced human bronchial contraction. 1997 Fundam Clin Pharmacol pmid:9243258
Kanli H and Terreros DA Transepithelial transport and cell volume control in proximal renal tubules from the teleost Carassius auratus. 1997 Acta Physiol. Scand. pmid:9246390
Cincu RN et al. S-adenosyl-L-methionine protects the liver against the cholestatic, cytotoxic, and vasoactive effects of leukotriene D4: a study with isolated and perfused rat liver. 1997 Hepatology pmid:9252142
Spector SL Leukotriene activity modulation in asthma. 1997 Drugs pmid:9279501
Wong WS et al. Effects of tyrosine kinase inhibitors on antigen challenge of guinea pig lung in vitro. 1997 J. Pharmacol. Exp. Ther. pmid:9336317
Beckh K et al. Effects of nitric oxide on leukotriene D4 decreased bile secretion in the perfused rat liver. 1997 Life Sci. pmid:9364199
Kagoshima M et al. Effect of Y-24180, a long-acting antagonist to platelet-activating factor (PAF), on PAF-induced reactions: a relationship between the partial structure of the compound and its duration of the action. 1997 Pharmacology pmid:9380772
Cibulsky SM and Thompson DC Absence of tachykinin involvement in leukotriene D4 and antigen-induced contraction of guinea pig isolated bronchus. 1997 J. Pharmacol. Exp. Ther. pmid:9399982
Beckh K et al. Impairment of hepatic transport processes in perfused rat liver by the specific CCK receptor antagonist loxiglumide. 1997 Res Exp Med (Berl) pmid:9406280
Gorenne I et al. Leukotriene D4 contractions in human airways are blocked by SK&F 96365, an inhibitor of receptor-mediated calcium entry. 1998 J. Pharmacol. Exp. Ther. pmid:9454796
Fujita M et al. Cysteinyl leukotrienes induce nasal symptoms of allergic rhinitis via a receptor-mediated mechanism in guinea pigs. 1997 Jpn. J. Pharmacol. pmid:9469641
Hoshino M et al. Leukotriene D4 activates mitogen-activated protein kinase through a protein kinase Calpha-Raf-1-dependent pathway in human monocytic leukemia THP-1 cells. 1998 J. Biol. Chem. pmid:9478929
Francis HP et al. The effects of a novel sulphidopeptide leukotriene antagonist, BAY x7195, against elicited bronchoconstriction in the anaesthetized guinea-pig. 1998 Br. J. Pharmacol. pmid:9484852
Yamaya M et al. Dipeptidase inhibitor and epithelial removal potentiate leukotriene D4-induced human tracheal smooth muscle contraction. 1998 Respir Physiol pmid:9496476
Basavappa S et al. Swelling-induced arachidonic acid release via the 85-kDa cPLA2 in human neuroblastoma cells. 1998 J. Neurophysiol. pmid:9497423
Capra V et al. Pharmacological characterization of the cysteinyl-leukotriene antagonists CGP 45715A (iralukast) and CGP 57698 in human airways in vitro. 1998 Br. J. Pharmacol. pmid:9504401
Kimura K et al. Modulation of platelet activating factor-induced glycogenolysis in the perfused rat liver after administration of endotoxin in vivo. 1998 J. Biochem. pmid:9504421
Daugschies A and Ruttkowski B Modulation of migration of Oesophagostomum dentatum larvae by inhibitors and products of eicosanoid metabolism. 1998 Int. J. Parasitol. pmid:9513001
Capra V et al. Identification and characterization of two cysteinyl-leukotriene high affinity binding sites with receptor characteristics in human lung parenchyma. 1998 Mol. Pharmacol. pmid:9547367
Przylipiak A et al. Influence of leukotrienes on in vitro growth of human mammary carcinoma cell line MCF-7. 1998 Eur. J. Obstet. Gynecol. Reprod. Biol. pmid:9550202
Zwaagstra ME et al. Synthesis and structure-activity relationships of carboxyflavones as structurally rigid CysLT1 (LTD4) receptor antagonists. 1998 J. Med. Chem. pmid:9554876
Cyrus CB et al. Leukotrienes C4 and D4 increase the ciliary beat frequency in human upper airway mucosa in vitro. 1998 Otolaryngol Head Neck Surg pmid:9560097
Habib GM et al. Leukotriene D4 and cystinyl-bis-glycine metabolism in membrane-bound dipeptidase-deficient mice. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9560193