LTD4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTD4?

LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTD4

MeSH term MeSH ID Detail
Aspergillosis, Allergic Bronchopulmonary D001229 2 associated lipids
Respirovirus Infections D010253 3 associated lipids
Peptic Ulcer Hemorrhage D010438 4 associated lipids
Nasal Obstruction D015508 4 associated lipids
Sneezing D012912 6 associated lipids
Asbestosis D001195 8 associated lipids
Enteritis D004751 8 associated lipids
Inflammatory Bowel Diseases D015212 9 associated lipids
Otitis Media with Effusion D010034 9 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTD4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTD4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTD4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTD4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTD4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTD4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTD4

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Authors Title Published Journal PubMed Link
Schwartz JI et al. Oral pharmacokinetics and food interaction of the leukotriene D4 receptor antagonist verlukast. 1993 Br J Clin Pharmacol pmid:12959296
Yoshikawa S et al. Modulation of acetylcholine release from the myenteric plexus of guinea-pig ileum by 5-lipoxygenase metabolites of arachidonic acid. 1993 Eur. J. Pharmacol. pmid:8223906
Dahlén B et al. Effect of the leukotriene receptor antagonist MK-0679 on baseline pulmonary function in aspirin sensitive asthmatic subjects. 1993 Thorax pmid:8303624
Manning PJ et al. Exercise-induced refractoriness in asthmatic subjects involves leukotriene and prostaglandin interdependent mechanisms. 1993 Am. Rev. Respir. Dis. pmid:8214949
Smith LJ et al. Inhibition of leukotriene D4-induced bronchoconstriction in subjects with asthma: a concentration-effect study of ICI 204,219. 1993 Clin. Pharmacol. Ther. pmid:8222486
Mastrocola T et al. Volume regulation in human fibroblasts: role of Ca2+ and 5-lipoxygenase products in the activation of the Cl- efflux. 1993 J. Membr. Biol. pmid:8271272
Shikada K and Tanaka S Influence of epithelium on the inhibition of melittin-induced contraction of guinea-pig isolated trachea by the potassium channel opener NIP-121. 1993 Br. J. Pharmacol. pmid:8401920
Metters KM and Zamboni RJ Photoaffinity labeling of the leukotriene D4 receptor in guinea pig lung. 1993 J. Biol. Chem. pmid:8384212
Diener M and Scharrer E The leukotriene D4 receptor blocker, SK&F 104353, inhibits volume regulation in isolated crypts from the rat distal colon. 1993 Eur. J. Pharmacol. pmid:8405093
Nagahisa A et al. Antiinflammatory and analgesic activity of CP-96,345: an orally active non-peptide substance P receptor antagonist. 1993 Regul. Pept. pmid:7692561