LTD4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTD4?

LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTD4

MeSH term MeSH ID Detail
Aspergillosis, Allergic Bronchopulmonary D001229 2 associated lipids
Respirovirus Infections D010253 3 associated lipids
Peptic Ulcer Hemorrhage D010438 4 associated lipids
Nasal Obstruction D015508 4 associated lipids
Sneezing D012912 6 associated lipids
Asbestosis D001195 8 associated lipids
Enteritis D004751 8 associated lipids
Inflammatory Bowel Diseases D015212 9 associated lipids
Otitis Media with Effusion D010034 9 associated lipids
Rhinitis D012220 10 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTD4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTD4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTD4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTD4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTD4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTD4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTD4

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Authors Title Published Journal PubMed Link
Krauss AH et al. Determination of leukotriene effects on human neutrophil chemotaxis in vitro by differential assessment of cell motility and polarity. 1994 J. Leukoc. Biol. pmid:8301217
Sjölander A and Grönroos E Leukotriene D4-induced signal transduction. 1994 Ann. N. Y. Acad. Sci. pmid:7825836
Krell RD et al. Preclinical exploration of the potential antiinflammatory properties of the peptide leukotriene antagonist ICI 204,219 (Accolate). 1994 Ann. N. Y. Acad. Sci. pmid:7825851
Wensing G et al. Effect of BAY x 7195, an oral receptor antagonist of cysteinyl-leukotrienes, on leukotriene D4-induced bronchoconstriction in normal volunteers. 1994 Eur. J. Clin. Pharmacol. pmid:7867675
Diamant Z et al. Effect of an inhaled neutral endopeptidase inhibitor, thiorphan, on airway responsiveness to leukotriene D4 in normal and asthmatic subjects. 1994 Eur. Respir. J. pmid:8013602
Chan CC et al. Leukotriene D4-induced increases in cytosolic calcium in THP-1 cells: dependence on extracellular calcium and inhibition with selective leukotriene D4 receptor antagonists. 1994 J. Pharmacol. Exp. Ther. pmid:8014876
Arakawa H et al. Effect of maturation on airway plasma exudation induced by eicosanoids in guinea pig. 1994 Eur. J. Pharmacol. pmid:7982451
Abela A and Daniel EE Neural and myogenic effects of leukotrienes C4, D4, and E4 on canine bronchial smooth muscle. 1994 Am. J. Physiol. pmid:8179018
Mion F et al. Short term effects of indomethacin on rat small intestinal permeability. Role of eicosanoids and platelet activating factor. 1994 Gut pmid:8174986
Salari H et al. Involvement of immunologic mechanisms in a guinea pig model of western red cedar asthma. 1994 J. Allergy Clin. Immunol. pmid:8182231