| MeSH term | MeSH ID | Detail |
|---|---|---|
| Aspergillosis, Allergic Bronchopulmonary | D001229 | 2 associated lipids |
| Respirovirus Infections | D010253 | 3 associated lipids |
| Peptic Ulcer Hemorrhage | D010438 | 4 associated lipids |
| Nasal Obstruction | D015508 | 4 associated lipids |
| Sneezing | D012912 | 6 associated lipids |
| Asbestosis | D001195 | 8 associated lipids |
| Enteritis | D004751 | 8 associated lipids |
| Inflammatory Bowel Diseases | D015212 | 9 associated lipids |
| Otitis Media with Effusion | D010034 | 9 associated lipids |
| Rhinitis | D012220 | 10 associated lipids |
LTD4
Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTD4?
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTD4
PubChem Associated disorders and diseases
What pathways are associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTD4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTD4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTD4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTD4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTD4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTD4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Maekawa A et al. | Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18931305 |
| Claesson HE et al. | Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma. | 2008 | FEBS J. | pmid:18647347 |
| Rehni AK et al. | Pharmacological modulation of leukotriene D(4) attenuates the development of opioid dependence in a mouse model of naloxone-induced opioid withdrawal syndrome. | 2008 | Eur. J. Pharmacol. | pmid:18840427 |
| Schain F et al. | Differential expression of cysteinyl leukotriene receptor 1 and 15-lipoxygenase-1 in non-Hodgkin lymphomas. | 2008 | Clin Lymphoma Myeloma | pmid:19064398 |
| Yudina Y et al. | Regulation of the eicosanoid pathway by tumour necrosis factor alpha and leukotriene D4 in intestinal epithelial cells. | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19042113 |
| Schelfhout V et al. | The effect of the leukotriene receptor antagonist zafirlukast on neurokinin A-induced bronchoconstriction in patients with asthma--A comparison with leukotriene D4 induced broncoconstriction. | 2008 | Pulm Pharmacol Ther | pmid:17611132 |
| Bengtsson AM et al. | Leukotriene D(4) induces AP-1 but not NFkappaB signaling in intestinal epithelial cells. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18083053 |
| Bossé Y et al. | Leukotriene D4-induced, epithelial cell-derived transforming growth factor beta1 in human bronchial smooth muscle cell proliferation. | 2008 | Clin. Exp. Allergy | pmid:18028462 |
| Ishimura M et al. | Effects of KP-496, a novel dual antagonist at the cysteinyl leukotriene receptor 1 and the thromboxane A(2) receptor, on airway obstruction in guinea pigs. | 2008 | Br. J. Pharmacol. | pmid:18037905 |
| Mizutani N et al. | Involvement of peroxynitrite in pollen-induced nasal blockage in guinea pigs. | 2008 | Eur. J. Pharmacol. | pmid:18191833 |
| Wienkötter N et al. | The effect of nigellone and thymoquinone on inhibiting trachea contraction and mucociliary clearance. | 2008 | Planta Med. | pmid:18219598 |
| Ge H et al. | Elucidation of signaling and functional activities of an orphan GPCR, GPR81. | 2008 | J. Lipid Res. | pmid:18174606 |
| Suzuki S et al. | Leukotriene D4 upregulates MUC2 gene transcription in human epithelial cells. | 2008 | Pharmacology | pmid:18176092 |
| Morishima H et al. | Ligation of Toll-like receptor 3 differentially regulates M2 and M3 muscarinic receptor expression and function in human airway smooth muscle cells. | 2008 | Int. Arch. Allergy Immunol. | pmid:17851256 |
| Profita M et al. | Cysteinyl leukotriene-1 receptor activation in a human bronchial epithelial cell line leads to signal transducer and activator of transcription 1-mediated eosinophil adhesion. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18305014 |
| Ito Y et al. | Guinea pig cysteinyl leukotriene receptor 2 (gpCysLT2) mediates cell proliferation and intracellular calcium mobilization by LTC4 and LTD4. | 2008 | BMB Rep | pmid:18315950 |
| Paruchuri S et al. | Leukotriene E4 activates peroxisome proliferator-activated receptor gamma and induces prostaglandin D2 generation by human mast cells. | 2008 | J. Biol. Chem. | pmid:18411276 |
| Goto HG et al. | Induction of apoptosis in an estrogen-responsive mouse Leydig tumor cell by leukotriene. | 2007 | Oncol. Rep. | pmid:17143502 |
| Stengel PW et al. | Inhaled anandamide reduces leukotriene D4-induced airway obstruction in guinea pigs. | 2007 | Eur. J. Pharmacol. | pmid:17166495 |
| Chiba Y et al. | Regional differences in vascular responsiveness of nasal mucosae isolated from naive guinea pigs. | 2007 | Auris Nasus Larynx | pmid:17056219 |