| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Airway Obstruction | D000402 | 13 associated lipids |
| Asbestosis | D001195 | 8 associated lipids |
| Aspergillosis, Allergic Bronchopulmonary | D001229 | 2 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Asthma, Exercise-Induced | D001250 | 10 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
LTD4
Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTD4?
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTD4
PubChem Associated disorders and diseases
What pathways are associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTD4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTD4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTD4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTD4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTD4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTD4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Suzuki R and Freed AN | Heparin inhibits hyperventilation-induced late-phase hyperreactivity in dogs. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:11779726 |
| Nagase T et al. | In vitro airway and tissue response to antigen in sensitized rats. Role of serotonin and leukotriene D4. | 1995 | Am. J. Respir. Crit. Care Med. | pmid:7599867 |
| Burghardt JS et al. | Lipid mediators in oxygen-induced airway remodeling and hyperresponsiveness in newborn rats. | 1996 | Am. J. Respir. Crit. Care Med. | pmid:8887572 |
| Underwood DC et al. | Persistent airway eosinophilia after leukotriene (LT) D4 administration in the guinea pig: modulation by the LTD4 receptor antagonist, pranlukast, or an interleukin-5 monoclonal antibody. | 1996 | Am. J. Respir. Crit. Care Med. | pmid:8887574 |
| Fukuyama S et al. | Effect of eotaxin and platelet-activating factor on airway inflammation and hyperresponsiveness in guinea pigs in vivo. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10852755 |
| Diamant Z et al. | The effect of inhaled leukotriene D4 and methacholine on sputum cell differentials in asthma. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9105062 |
| Nagase T et al. | Roles of calcitonin gene-related peptide (CGRP) in hyperpnea-induced constriction in guinea pigs. | 1996 | Am. J. Respir. Crit. Care Med. | pmid:8912779 |
| Dahlén B et al. | Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9563738 |
| Donnelly AL et al. | The leukotriene D4-receptor antagonist, ICI 204,219, relieves symptoms of acute seasonal allergic rhinitis. | 1995 | Am. J. Respir. Crit. Care Med. | pmid:7767514 |
| Mulder A et al. | Effect of inhaled leukotriene D4 on airway eosinophilia and airway hyperresponsiveness in asthmatic subjects. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10228127 |
| Gauvreau GM et al. | Inhaled leukotriene E(4), but not leukotriene D(4), increased airway inflammatory cells in subjects with atopic asthma. | 2001 | Am. J. Respir. Crit. Care Med. | pmid:11704602 |
| Muñoz NM et al. | Eosinophil chemotaxis inhibited by 5-lipoxygenase blockade and leukotriene receptor antagonism. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9105085 |
| Ellis JL and Undem BJ | Role of cysteinyl-leukotrienes and histamine in mediating intrinsic tone in isolated human bronchi. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:8111568 |
| Echazarreta AL et al. | Pulmonary gas exchange and sputum cellular responses to inhaled leukotriene D(4) in asthma. | 2001 | Am. J. Respir. Crit. Care Med. | pmid:11463588 |
| Hasday JD et al. | Anti-inflammatory effects of zileuton in a subpopulation of allergic asthmatics. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10764316 |
| Aharony D | Pharmacology of leukotriene receptor antagonists | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9620942 |
| Nag S et al. | Interleukin-2-induced increased airway responsiveness and lung Th2 cytokine expression occur after antigen challenge through the leukotriene pathway. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:12045130 |
| Venugopal CS et al. | Comparative responses of bronchial rings to mediators of airway hyperreactivity in healthy horses and those affected with summer pasture-associated obstructive pulmonary disease. | 2001 | Am. J. Vet. Res. | pmid:11212036 |
| Lavoie JP et al. | Comparison of effects of dexamethasone and the leukotriene D4 receptor antagonist L-708,738 on lung function and airway cytologic findings in horses with recurrent airway obstruction. | 2002 | Am. J. Vet. Res. | pmid:11939323 |
| Manning PJ et al. | Exercise-induced refractoriness in asthmatic subjects involves leukotriene and prostaglandin interdependent mechanisms. | 1993 | Am. Rev. Respir. Dis. | pmid:8214949 |