| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Airway Obstruction | D000402 | 13 associated lipids |
| Asbestosis | D001195 | 8 associated lipids |
| Aspergillosis, Allergic Bronchopulmonary | D001229 | 2 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Asthma, Exercise-Induced | D001250 | 10 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
LTD4
Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTD4?
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTD4
PubChem Associated disorders and diseases
What pathways are associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTD4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTD4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTD4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTD4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTD4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTD4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lee SP et al. | Crosstalk between prostaglandin E2 and leukotriene B4 regulates phagocytosis in alveolar macrophages via combinatorial effects on cyclic AMP. | 2009 | J. Immunol. | pmid:19109185 |
| Broom OJ and Nielsen OH | [The role of cysteinyl leukotrienes in chronic inflammation and neoplasia of the intestine]. | 2009 | Ugeskr. Laeg. | pmid:19174041 |
| Baker N et al. | Lipoxin A4: anti-inflammatory and anti-angiogenic impact on endothelial cells. | 2009 | J. Immunol. | pmid:19265161 |
| Mizutani N et al. | Effect of TA-270, a novel quinolinone derivative, on antigen-induced nasal blockage in a guinea pig model of allergic rhinitis. | 2009 | Eur. J. Pharmacol. | pmid:19022242 |
| Fang SH et al. | Pranlukast attenuates ischemia-like injury in endothelial cells via inhibiting reactive oxygen species production and nuclear factor-kappaB activation. | 2009 | J. Cardiovasc. Pharmacol. | pmid:19129732 |
| Claesson HE | On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma. | 2009 | Prostaglandins Other Lipid Mediat. | pmid:19130894 |
| Dayyat E et al. | Leukotriene pathways and in vitro adenotonsillar cell proliferation in children with obstructive sleep apnea. | 2009 | Chest | pmid:19118273 |
| Boehmler AM et al. | The CysLT1 ligand leukotriene D4 supports alpha4beta1- and alpha5beta1-mediated adhesion and proliferation of CD34+ hematopoietic progenitor cells. | 2009 | J. Immunol. | pmid:19454674 |
| Mori M et al. | Eosinophil superoxide anion generation induced by adhesion molecules and leukotriene D4. | 2009 | Int. Arch. Allergy Immunol. | pmid:19494502 |
| Taylor-Clark TE et al. | Leukotriene D4 increases the excitability of capsaicin-sensitive nasal sensory nerves to electrical and chemical stimuli. | 2008 | Br. J. Pharmacol. | pmid:18500362 |
| Woszczek G et al. | IL-10 inhibits cysteinyl leukotriene-induced activation of human monocytes and monocyte-derived dendritic cells. | 2008 | J. Immunol. | pmid:18490762 |
| Tamaoka M et al. | The epidermal growth factor receptor mediates allergic airway remodelling in the rat. | 2008 | Eur. Respir. J. | pmid:18653647 |
| Schain F et al. | Evidence for a pathophysiological role of cysteinyl leukotrienes in classical Hodgkin lymphoma. | 2008 | Int. J. Cancer | pmid:18704935 |
| Woszczek G et al. | Leukotriene D(4) induces gene expression in human monocytes through cysteinyl leukotriene type I receptor. | 2008 | J. Allergy Clin. Immunol. | pmid:18028998 |
| Lecca D et al. | The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. | 2008 | PLoS ONE | pmid:18974869 |
| Huang XJ et al. | Activation of CysLT receptors induces astrocyte proliferation and death after oxygen-glucose deprivation. | 2008 | Glia | pmid:17910051 |
| Skogvall S et al. | Discovery of a potent and long-acting bronchorelaxing capsazepinoid, RESPIR 4-95. | 2008 | Pulm Pharmacol Ther | pmid:17374498 |
| Thompson C et al. | Leukotriene D4 up-regulates furin expression through CysLT1 receptor signaling. | 2008 | Am. J. Respir. Cell Mol. Biol. | pmid:18323532 |
| Macdonald D et al. | Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18276139 |
| Talukder JR et al. | Mechanism of leukotriene D4 inhibition of Na-alanine cotransport in intestinal epithelial cells. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18436626 |