| MeSH term | MeSH ID | Detail |
|---|---|---|
| Endotoxemia | D019446 | 27 associated lipids |
| Respiratory Syncytial Virus Infections | D018357 | 10 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Bronchial Hyperreactivity | D016535 | 15 associated lipids |
| Nasal Obstruction | D015508 | 4 associated lipids |
| Leukemia, Lymphocytic, Chronic, B-Cell | D015451 | 25 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Inflammatory Bowel Diseases | D015212 | 9 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
LTD4
Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTD4?
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTD4
PubChem Associated disorders and diseases
What pathways are associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTD4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTD4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTD4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTD4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTD4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTD4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hisamatsu K et al. | Effect of leukotriene C4 exposure on ciliated cells of the nasal mucosa. | 1996 | Prostaglandins | pmid:8900445 |
| Hendeles L and Marshik PL | Zileuton: a new therapy for asthma or just the first of a new class of drugs. | 1996 Jul-Aug | Ann Pharmacother | pmid:8826576 |
| Pedersen KE et al. | Cysteinyl leukotrienes induce P-selectin expression in human endothelial cells via a non-CysLT1 receptor-mediated mechanism. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9152370 |
| Sampson SE et al. | Effect of inhaled prostaglandin D2 in normal and atopic subjects, and of pretreatment with leukotriene D4. | 1997 | Thorax | pmid:9227716 |
| Beckh K et al. | Impairment of hepatic transport processes in perfused rat liver by the specific CCK receptor antagonist loxiglumide. | 1997 | Res Exp Med (Berl) | pmid:9406280 |
| Fujita M et al. | Cysteinyl leukotrienes induce nasal symptoms of allergic rhinitis via a receptor-mediated mechanism in guinea pigs. | 1997 | Jpn. J. Pharmacol. | pmid:9469641 |
| Beckh K et al. | Effects of nitric oxide on leukotriene D4 decreased bile secretion in the perfused rat liver. | 1997 | Life Sci. | pmid:9364199 |
| Kagoshima M et al. | Effect of Y-24180, a long-acting antagonist to platelet-activating factor (PAF), on PAF-induced reactions: a relationship between the partial structure of the compound and its duration of the action. | 1997 | Pharmacology | pmid:9380772 |
| Cincu RN et al. | S-adenosyl-L-methionine protects the liver against the cholestatic, cytotoxic, and vasoactive effects of leukotriene D4: a study with isolated and perfused rat liver. | 1997 | Hepatology | pmid:9252142 |
| Goldhill J et al. | Interleukin-4 modulates cholinergic neural control of mouse small intestinal longitudinal muscle. | 1997 | Am. J. Physiol. | pmid:9176223 |
| Gissurarson SR et al. | Effect of lobaric acid on cysteinyl-leukotriene formation and contractile activity of guinea pig taenia coli. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9023290 |
| Joki S and Saano V | Influence of ageing on ciliary beat frequency and on ciliary response to leukotriene D4 in guinea-pig tracheal epithelium. | 1997 | Clin. Exp. Pharmacol. Physiol. | pmid:9075591 |
| Uno T et al. | Participation of leukotriene D4 and tumor necrosis factor on lipopolysaccharide-induced airway hyperresponsiveness in guinea pigs. | 1997 | Biol. Pharm. Bull. | pmid:9145204 |
| Diamant Z et al. | The effect of inhaled leukotriene D4 and methacholine on sputum cell differentials in asthma. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9105062 |
| Pedersen S et al. | Leukotriene D4-induced Ca2+ mobilization in Ehrlich ascites tumor cells. | 1997 | J. Membr. Biol. | pmid:9002425 |
| Kubes P | Nitric oxide and microvascular permeability: a continuing dilemma. | 1997 | Eur. Respir. J. | pmid:9032483 |
| Kageyama N et al. | Role of endogenous nitric oxide in airway microvascular leakage induced by inflammatory mediators. | 1997 | Eur. Respir. J. | pmid:9032485 |
| Tvaermose-Nielsen O et al. | Discovery of OT4003, a novel, potent, and orally active cys-LT1 receptor antagonist. | 1997 | Bioorg. Med. Chem. | pmid:9061206 |
| Ohd JF et al. | Leukotriene D4-induced signalling events in human epithelial cells: G alpha i3 activation and translocation. | 1997 | Adv. Exp. Med. Biol. | pmid:9561113 |
| Muñoz NM et al. | Eosinophil chemotaxis inhibited by 5-lipoxygenase blockade and leukotriene receptor antagonism. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9105085 |