Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Wen FQ et al. | Eicosanoid profile in cultured human pulmonary artery smooth muscle cells treated with IL-1 beta and TNF alpha. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9758210 |
Francis HP et al. | The effects of a novel sulphidopeptide leukotriene antagonist, BAY x7195, against elicited bronchoconstriction in the anaesthetized guinea-pig. | 1998 | Br. J. Pharmacol. | pmid:9484852 |
Cyrus CB et al. | Leukotrienes C4 and D4 increase the ciliary beat frequency in human upper airway mucosa in vitro. | 1998 | Otolaryngol Head Neck Surg | pmid:9560097 |
Dahlén B et al. | Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9563738 |
Capra V et al. | Pharmacological characterization of the cysteinyl-leukotriene antagonists CGP 45715A (iralukast) and CGP 57698 in human airways in vitro. | 1998 | Br. J. Pharmacol. | pmid:9504401 |
Chambers RJ et al. | Development of new chromanol antagonists of leukotriene D4. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9873435 |
Nagayama S et al. | Increased sensitivity to vincristine of MDR cells by the leukotriene D4 receptor antagonist, ONO-1078. | 1998 | Cancer Lett. | pmid:9751271 |
Geirsson A et al. | Potentiating effects of pertussis toxin on leukotriene C4 induced formation of inositol phosphate and prostacyclin in human umbilical vein endothelial cells. | 1998 | J. Cell. Physiol. | pmid:9731750 |
Kim N et al. | Leukotriene D4-induced contraction of cat esophageal and lower esophageal sphincter circular smooth muscle. | 1998 | Gastroenterology | pmid:9753495 |
Grönroos E et al. | Leukotriene D4 induces a rapid increase in cAMP in the human epithelial cell line, Int 407: a potential role for this signal in the regulation of calcium influx through the plasma membrane. | 1998 | Cell Calcium | pmid:9793684 |
Tsang F et al. | Effects of mitogen-activated protein kinase kinase inhibitor PD 098059 on antigen challenge of guinea-pig airways in vitro. | 1998 | Br. J. Pharmacol. | pmid:9776345 |
Panettieri RA et al. | Effects of LTD4 on human airway smooth muscle cell proliferation, matrix expression, and contraction In vitro: differential sensitivity to cysteinyl leukotriene receptor antagonists. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9730873 |
Lane SJ | Leukotriene antagonism in asthma and rhinitis. | 1998 | Respir Med | pmid:9850362 |
Smith LJ et al. | A single dose of zafirlukast reduces LTD4-induced bronchoconstriction in patients on maintenance inhaled corticosteroid therapy. | 1998 | Ann. Allergy Asthma Immunol. | pmid:9690572 |
Sparatore A and Sparatore F | Synthesis and preliminary pharmacological investigation of some 2-[4-(dialkylaminoalkoxy)phenyl]benzotriazoles and their N-oxides. | 1998 | Farmaco | pmid:9604317 |
Kawashima Y et al. | Surface-modified antiasthmatic dry powder aerosols inhaled intratracheally reduce the pharmacologically effective dose. | 1998 | Pharm. Res. | pmid:9833999 |
Przylipiak A et al. | Influence of leukotrienes on in vitro growth of human mammary carcinoma cell line MCF-7. | 1998 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:9550202 |
Traianedes K et al. | 5-Lipoxygenase metabolites inhibit bone formation in vitro. | 1998 | Endocrinology | pmid:9645691 |
Daugschies A and Ruttkowski B | Modulation of migration of Oesophagostomum dentatum larvae by inhibitors and products of eicosanoid metabolism. | 1998 | Int. J. Parasitol. | pmid:9513001 |
Jonsson EW | Functional characterisation of receptors for cysteinyl leukotrienes in smooth muscle. | 1998 | Acta Physiol Scand Suppl | pmid:9597121 |