LTD4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTD4?

LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTD4

MeSH term MeSH ID Detail
Aspergillosis, Allergic Bronchopulmonary D001229 2 associated lipids
Respirovirus Infections D010253 3 associated lipids
Peptic Ulcer Hemorrhage D010438 4 associated lipids
Nasal Obstruction D015508 4 associated lipids
Sneezing D012912 6 associated lipids
Asbestosis D001195 8 associated lipids
Enteritis D004751 8 associated lipids
Inflammatory Bowel Diseases D015212 9 associated lipids
Otitis Media with Effusion D010034 9 associated lipids
Rhinitis D012220 10 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Asthma, Exercise-Induced D001250 10 associated lipids
Influenza, Human D007251 11 associated lipids
Airway Obstruction D000402 13 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Carotid Stenosis D016893 15 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Cough D003371 19 associated lipids
Brain Edema D001929 20 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTD4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTD4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTD4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTD4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTD4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTD4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTD4

Download all related citations
Per page 10 20 50 100 | Total 640
Authors Title Published Journal PubMed Link
Wen FQ et al. Eicosanoid profile in cultured human pulmonary artery smooth muscle cells treated with IL-1 beta and TNF alpha. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9758210
Francis HP et al. The effects of a novel sulphidopeptide leukotriene antagonist, BAY x7195, against elicited bronchoconstriction in the anaesthetized guinea-pig. 1998 Br. J. Pharmacol. pmid:9484852
Cyrus CB et al. Leukotrienes C4 and D4 increase the ciliary beat frequency in human upper airway mucosa in vitro. 1998 Otolaryngol Head Neck Surg pmid:9560097
Dahlén B et al. Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics. 1998 Am. J. Respir. Crit. Care Med. pmid:9563738
Capra V et al. Pharmacological characterization of the cysteinyl-leukotriene antagonists CGP 45715A (iralukast) and CGP 57698 in human airways in vitro. 1998 Br. J. Pharmacol. pmid:9504401
Chambers RJ et al. Development of new chromanol antagonists of leukotriene D4. 1998 Bioorg. Med. Chem. Lett. pmid:9873435
Nagayama S et al. Increased sensitivity to vincristine of MDR cells by the leukotriene D4 receptor antagonist, ONO-1078. 1998 Cancer Lett. pmid:9751271
Geirsson A et al. Potentiating effects of pertussis toxin on leukotriene C4 induced formation of inositol phosphate and prostacyclin in human umbilical vein endothelial cells. 1998 J. Cell. Physiol. pmid:9731750
Kim N et al. Leukotriene D4-induced contraction of cat esophageal and lower esophageal sphincter circular smooth muscle. 1998 Gastroenterology pmid:9753495
Grönroos E et al. Leukotriene D4 induces a rapid increase in cAMP in the human epithelial cell line, Int 407: a potential role for this signal in the regulation of calcium influx through the plasma membrane. 1998 Cell Calcium pmid:9793684
Tsang F et al. Effects of mitogen-activated protein kinase kinase inhibitor PD 098059 on antigen challenge of guinea-pig airways in vitro. 1998 Br. J. Pharmacol. pmid:9776345
Panettieri RA et al. Effects of LTD4 on human airway smooth muscle cell proliferation, matrix expression, and contraction In vitro: differential sensitivity to cysteinyl leukotriene receptor antagonists. 1998 Am. J. Respir. Cell Mol. Biol. pmid:9730873
Lane SJ Leukotriene antagonism in asthma and rhinitis. 1998 Respir Med pmid:9850362
Smith LJ et al. A single dose of zafirlukast reduces LTD4-induced bronchoconstriction in patients on maintenance inhaled corticosteroid therapy. 1998 Ann. Allergy Asthma Immunol. pmid:9690572
Sparatore A and Sparatore F Synthesis and preliminary pharmacological investigation of some 2-[4-(dialkylaminoalkoxy)phenyl]benzotriazoles and their N-oxides. 1998 Farmaco pmid:9604317
Kawashima Y et al. Surface-modified antiasthmatic dry powder aerosols inhaled intratracheally reduce the pharmacologically effective dose. 1998 Pharm. Res. pmid:9833999
Przylipiak A et al. Influence of leukotrienes on in vitro growth of human mammary carcinoma cell line MCF-7. 1998 Eur. J. Obstet. Gynecol. Reprod. Biol. pmid:9550202
Traianedes K et al. 5-Lipoxygenase metabolites inhibit bone formation in vitro. 1998 Endocrinology pmid:9645691
Daugschies A and Ruttkowski B Modulation of migration of Oesophagostomum dentatum larvae by inhibitors and products of eicosanoid metabolism. 1998 Int. J. Parasitol. pmid:9513001
Jonsson EW Functional characterisation of receptors for cysteinyl leukotrienes in smooth muscle. 1998 Acta Physiol Scand Suppl pmid:9597121