Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Taylor-Clark TE et al. | Leukotriene D4 increases the excitability of capsaicin-sensitive nasal sensory nerves to electrical and chemical stimuli. | 2008 | Br. J. Pharmacol. | pmid:18500362 |
Woszczek G et al. | IL-10 inhibits cysteinyl leukotriene-induced activation of human monocytes and monocyte-derived dendritic cells. | 2008 | J. Immunol. | pmid:18490762 |
Tamaoka M et al. | The epidermal growth factor receptor mediates allergic airway remodelling in the rat. | 2008 | Eur. Respir. J. | pmid:18653647 |
Schain F et al. | Evidence for a pathophysiological role of cysteinyl leukotrienes in classical Hodgkin lymphoma. | 2008 | Int. J. Cancer | pmid:18704935 |
Woszczek G et al. | Leukotriene D(4) induces gene expression in human monocytes through cysteinyl leukotriene type I receptor. | 2008 | J. Allergy Clin. Immunol. | pmid:18028998 |
Maekawa A et al. | Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18931305 |
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Huang XJ et al. | Activation of CysLT receptors induces astrocyte proliferation and death after oxygen-glucose deprivation. | 2008 | Glia | pmid:17910051 |
Skogvall S et al. | Discovery of a potent and long-acting bronchorelaxing capsazepinoid, RESPIR 4-95. | 2008 | Pulm Pharmacol Ther | pmid:17374498 |
Schelfhout V et al. | The effect of the leukotriene receptor antagonist zafirlukast on neurokinin A-induced bronchoconstriction in patients with asthma--A comparison with leukotriene D4 induced broncoconstriction. | 2008 | Pulm Pharmacol Ther | pmid:17611132 |
Bengtsson AM et al. | Leukotriene D(4) induces AP-1 but not NFkappaB signaling in intestinal epithelial cells. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18083053 |
Bossé Y et al. | Leukotriene D4-induced, epithelial cell-derived transforming growth factor beta1 in human bronchial smooth muscle cell proliferation. | 2008 | Clin. Exp. Allergy | pmid:18028462 |
Ishimura M et al. | Effects of KP-496, a novel dual antagonist at the cysteinyl leukotriene receptor 1 and the thromboxane A(2) receptor, on airway obstruction in guinea pigs. | 2008 | Br. J. Pharmacol. | pmid:18037905 |
Mizutani N et al. | Involvement of peroxynitrite in pollen-induced nasal blockage in guinea pigs. | 2008 | Eur. J. Pharmacol. | pmid:18191833 |
Wienkötter N et al. | The effect of nigellone and thymoquinone on inhibiting trachea contraction and mucociliary clearance. | 2008 | Planta Med. | pmid:18219598 |
Ge H et al. | Elucidation of signaling and functional activities of an orphan GPCR, GPR81. | 2008 | J. Lipid Res. | pmid:18174606 |
Suzuki S et al. | Leukotriene D4 upregulates MUC2 gene transcription in human epithelial cells. | 2008 | Pharmacology | pmid:18176092 |
Morishima H et al. | Ligation of Toll-like receptor 3 differentially regulates M2 and M3 muscarinic receptor expression and function in human airway smooth muscle cells. | 2008 | Int. Arch. Allergy Immunol. | pmid:17851256 |
Profita M et al. | Cysteinyl leukotriene-1 receptor activation in a human bronchial epithelial cell line leads to signal transducer and activator of transcription 1-mediated eosinophil adhesion. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18305014 |
Thompson C et al. | Leukotriene D4 up-regulates furin expression through CysLT1 receptor signaling. | 2008 | Am. J. Respir. Cell Mol. Biol. | pmid:18323532 |
Macdonald D et al. | Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18276139 |
Talukder JR et al. | Mechanism of leukotriene D4 inhibition of Na-alanine cotransport in intestinal epithelial cells. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18436626 |
Ito Y et al. | Guinea pig cysteinyl leukotriene receptor 2 (gpCysLT2) mediates cell proliferation and intracellular calcium mobilization by LTC4 and LTD4. | 2008 | BMB Rep | pmid:18315950 |
Paruchuri S et al. | Leukotriene E4 activates peroxisome proliferator-activated receptor gamma and induces prostaglandin D2 generation by human mast cells. | 2008 | J. Biol. Chem. | pmid:18411276 |
Yoshisue H et al. | Cysteinyl leukotrienes synergize with growth factors to induce proliferation of human bronchial fibroblasts. | 2007 | J. Allergy Clin. Immunol. | pmid:17208594 |
Lee KS et al. | Cysteinyl leukotriene upregulates IL-11 expression in allergic airway disease of mice. | 2007 | J. Allergy Clin. Immunol. | pmid:17208595 |
Skogvall S et al. | Effects of capsazepine on human small airway responsiveness unravel a novel class of bronchorelaxants. | 2007 | Pulm Pharmacol Ther | pmid:16731017 |
Kopp MV et al. | Omalizumab (Xolair) in children with seasonal allergic rhinitis: leukotriene release as a potential in vitro parameter to monitor therapeutic effects. | 2007 | Pediatr Allergy Immunol | pmid:17680911 |
Capra V et al. | Cysteinyl-leukotrienes and their receptors in asthma and other inflammatory diseases: critical update and emerging trends. | 2007 | Med Res Rev | pmid:16894531 |
Shirasaki H et al. | Agonist- and T(H)2 cytokine-induced up-regulation of cysteinyl leukotriene receptor messenger RNA in human monocytes. | 2007 | Ann. Allergy Asthma Immunol. | pmid:17941281 |
Hu X et al. | [Effects of cysteinyl receptor agonist and antagonists on rat primary cortical neurons]. | 2007 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:17443896 |
Peng F et al. | [Cysteinyl leukotriene receptor 1 antagonist pranlukast modulates differentiation of SK-N-SH cells]. | 2007 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:17443897 |
Tokuriki S et al. | Leukotriene D(4) enhances the function of endothelin-1-primed fibroblasts. | 2007 | Clin. Immunol. | pmid:17627891 |
Lötzer K et al. | 5-Lipoxygenase/cyclooxygenase-2 cross-talk through cysteinyl leukotriene receptor 2 in endothelial cells. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17991613 |
Jiang Y et al. | CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells. | 2007 | Blood | pmid:17693579 |
Peres CM et al. | Specific leukotriene receptors couple to distinct G proteins to effect stimulation of alveolar macrophage host defense functions. | 2007 | J. Immunol. | pmid:17911632 |
Goto HG et al. | Induction of apoptosis in an estrogen-responsive mouse Leydig tumor cell by leukotriene. | 2007 | Oncol. Rep. | pmid:17143502 |
Stengel PW et al. | Inhaled anandamide reduces leukotriene D4-induced airway obstruction in guinea pigs. | 2007 | Eur. J. Pharmacol. | pmid:17166495 |
Chiba Y et al. | Regional differences in vascular responsiveness of nasal mucosae isolated from naive guinea pigs. | 2007 | Auris Nasus Larynx | pmid:17056219 |
Yang YY et al. | Effect of chronic CB1 cannabinoid receptor antagonism on livers of rats with biliary cirrhosis. | 2007 | Clin. Sci. | pmid:17176248 |
Bai CH et al. | The inhibitory effect of the leukotriene receptor antagonist on leukotriene D4-induced MUC2/5AC gene expression and mucin secretion in human airway epithelial cells. | 2007 | Auris Nasus Larynx | pmid:17223000 |
Chiba Y et al. | Impaired norepinephrine-mediated contraction of isolated nasal mucosa in guinea pigs with allergic rhinitis. | 2006 Jul-Aug | Am J Rhinol | pmid:16955783 |
Ishimura M et al. | Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea. | 2006 | Allergol Int | pmid:17130683 |
Thivierge M et al. | Toll-like receptor agonists differentially regulate cysteinyl-leukotriene receptor 1 expression and function in human dendritic cells. | 2006 | J. Allergy Clin. Immunol. | pmid:16675346 |
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Dahlén SE | Treatment of asthma with antileukotrienes: first line or last resort therapy? | 2006 | Eur. J. Pharmacol. | pmid:16510137 |
Gyllfors P et al. | Bronchial responsiveness to leukotriene D4 is resistant to inhaled fluticasone propionate. | 2006 | J. Allergy Clin. Immunol. | pmid:16815141 |
Hemelaers L et al. | Cysteinyl-leukotrienes contribute to sputum eosinophil chemotactic activity in asthmatics. | 2006 | Allergy | pmid:16364169 |
Mezhybovska M et al. | The inflammatory mediator leukotriene D4 induces beta-catenin signaling and its association with antiapoptotic Bcl-2 in intestinal epithelial cells. | 2006 | J. Biol. Chem. | pmid:16407243 |
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Cui S et al. | Effects of platelet-activating factor, thromboxane A2 and leukotriene D4 on isolated perfused rat liver. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16846785 |
Tanaka Y et al. | Different mechanisms between thromboxane A2- and leukotriene D4-induced nasal blockage in guinea pigs. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16939879 |
Chiba Y et al. | Effects of 1400W, a potent selective inducible NOS inhibitor, on histamine- and leukotriene D4-induced relaxation of isolated guinea pig nasal mucosa. | 2006 | Nitric Oxide | pmid:16442819 |
Lefebvre B et al. | Effect of 5-lipoxygenase blockade on blood pressure and acetylcholine-evoked endothelium-dependent contraction in aorta from spontaneously hypertensive rats. | 2006 | J. Hypertens. | pmid:16331105 |
Rovati GE et al. | Cysteinyl-leukotrienes in the regulation of beta2-adrenoceptor function: an in vitro model of asthma. | 2006 | Respir. Res. | pmid:16875498 |
Lamoureux J et al. | Leukotriene D4 enhances immunoglobulin production in CD40-activated human B lymphocytes. | 2006 | J. Allergy Clin. Immunol. | pmid:16630953 |
Guo HF and Zhong Y | Requirement of Akt to mediate long-term synaptic depression in Drosophila. | 2006 | J. Neurosci. | pmid:16611817 |
Ravasi S et al. | CysLT1 receptor-induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1/2 phosphorylation. | 2006 | Respir. Res. | pmid:16553950 |
Bouchelouche K and Bouchelouche P | Cysteinyl leukotriene D4 increases human detrusor muscle responsiveness to histamine. | 2006 | J. Urol. | pmid:16753444 |
Thompson C et al. | CysLT1 receptor engagement induces activator protein-1- and NF-kappaB-dependent IL-8 expression. | 2006 | Am. J. Respir. Cell Mol. Biol. | pmid:16809637 |
Paruchuri S et al. | Endogenous production of leukotriene D4 mediates autocrine survival and proliferation via CysLT1 receptor signalling in intestinal epithelial cells. | 2006 | Oncogene | pmid:16715140 |
Wang ML et al. | Leukotriene D4 induces brain edema and enhances CysLT2 receptor-mediated aquaporin 4 expression. | 2006 | Biochem. Biophys. Res. Commun. | pmid:17010308 |
Shimoda H et al. | Anti type I allergic property of Japanese butterbur extract and its mast cell degranulation inhibitory ingredients. | 2006 | J. Agric. Food Chem. | pmid:16608208 |
Mayatepek E et al. | A patient with neurological symptoms and abnormal leukotriene metabolism: a new defect in leukotriene biosynthesis. | 2005 | Ann. Neurol. | pmid:16315285 |
Neves JS et al. | Evaluating the prophylactic potential of the phtalimide derivative LASSBio 552 on allergen-evoked inflammation in rats. | 2005 | Eur. J. Pharmacol. | pmid:15792791 |
Naik S et al. | Regulation of cysteinyl leukotriene type 1 receptor internalization and signaling. | 2005 | J. Biol. Chem. | pmid:15590629 |
Capra V et al. | CysLT1 receptor is a target for extracellular nucleotide-induced heterologous desensitization: a possible feedback mechanism in inflammation. | 2005 | J. Cell. Sci. | pmid:16306225 |
Matsuse H et al. | Naturally occurring parainfluenza virus 3 infection in adults induces mild exacerbation of asthma associated with increased sputum concentrations of cysteinyl leukotrienes. | 2005 | Int. Arch. Allergy Immunol. | pmid:16215328 |
Nielsen CK et al. | Leukotriene D4 activates distinct G-proteins in intestinal epithelial cells to regulate stress fibre formation and to generate intracellular Ca2+ mobilisation and ERK1/2 activation. | 2005 | Exp. Cell Res. | pmid:15541723 |
Ishinaga H et al. | Pranlukast inhibits NF-kappaB activation and MUC2 gene expression in cultured human epithelial cells. | 2005 | Pharmacology | pmid:15475658 |
Mezhybovska M et al. | Pro-inflammatory mediator leukotriene D4 induces transcriptional activity of potentially oncogenic genes. | 2005 | Biochem. Soc. Trans. | pmid:16042577 |
Kato J et al. | Leukotriene D4 potentiates fibronectin-induced migration of human lung fibroblasts. | 2005 | Clin. Immunol. | pmid:16109507 |
Prinz I et al. | The type 1 cysteinyl leukotriene receptor triggers calcium influx and chemotaxis in mouse alpha beta- and gamma delta effector T cells. | 2005 | J. Immunol. | pmid:16002666 |
Paruchuri S et al. | The pro-inflammatory mediator leukotriene D4 induces phosphatidylinositol 3-kinase and Rac-dependent migration of intestinal epithelial cells. | 2005 | J. Biol. Chem. | pmid:15657050 |
Nielsen CK et al. | A novel localization of the G-protein-coupled CysLT1 receptor in the nucleus of colorectal adenocarcinoma cells. | 2005 | Cancer Res. | pmid:15705869 |
Trandafir CC et al. | Cysteinyl leukotrienes and leukotriene B mediate vasoconstriction to arginine vasopressin in rat basilar artery. | 2005 | Clin. Exp. Pharmacol. Physiol. | pmid:16445567 |
Bochner BS and Busse WW | Allergy and asthma. | 2005 | J. Allergy Clin. Immunol. | pmid:15867851 |
Parhamifar L et al. | Activation of cPLA2 is required for leukotriene D4-induced proliferation in colon cancer cells. | 2005 | Carcinogenesis | pmid:15975962 |
Kumasawa F et al. | Apoptosis signal-regulating kinase 1 in leukotriene D(4)-induced activator protein-1 activation in airway smooth muscle cells. | 2005 | Eur. J. Pharmacol. | pmid:15970283 |
Nagata M et al. | Effect of the cysteinyl leukotriene antagonist pranlukast on transendothelial migration of eosinophils. | 2005 | Int. Arch. Allergy Immunol. | pmid:15947477 |
Kato Y et al. | Leukotriene D4 induces production of transforming growth factor-beta1 by eosinophils. | 2005 | Int. Arch. Allergy Immunol. | pmid:15947480 |
Gauvreau GM et al. | Expression of functional cysteinyl leukotriene receptors by human basophils. | 2005 | J. Allergy Clin. Immunol. | pmid:15990778 |
Fernandez J et al. | Isoquercitrin from Argemone platyceras inhibits carbachol and leukotriene D4-induced contraction in guinea-pig airways. | 2005 | Eur. J. Pharmacol. | pmid:16202993 |
Casas A et al. | Leukotriene D4-induced hypoxaemia in asthma is mediated by the cys-leukotriene1 receptor. | 2005 | Eur. Respir. J. | pmid:16135725 |
Gyllfors P et al. | Relation between bronchial responsiveness to inhaled leukotriene D4 and markers of leukotriene biosynthesis. | 2005 | Thorax | pmid:16055619 |