Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Venugopal CS et al. | Comparative responses of bronchial rings to mediators of airway hyperreactivity in healthy horses and those affected with summer pasture-associated obstructive pulmonary disease. | 2001 | Am. J. Vet. Res. | pmid:11212036 |
Tohda Y et al. | Role of chemical mediators in airway hyperresponsiveness in an asthmatic model. | 2001 | Respiration | pmid:11223734 |
Maekawa A et al. | Identification in mice of two isoforms of the cysteinyl leukotriene 1 receptor that result from alternative splicing. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11226226 |
Saegusa S et al. | Leukotriene D(4)-induced Rho-mediated actin reorganization in human bronchial smooth muscle cells. | 2001 | Eur. J. Pharmacol. | pmid:11226389 |
Aoki M et al. | Antiasthmatic effect of YM976, a novel PDE4 inhibitor, in guinea pigs. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11259541 |
Massoumi R and Sjölander A | Leukotriene D(4) affects localisation of vinculin in intestinal epithelial cells via distinct tyrosine kinase and protein kinase C controlled events. | 2001 | J. Cell. Sci. | pmid:11329379 |
Bouchelouche K et al. | The action of cysteinyl-leukotrienes on intracellular calcium mobilization in human detrusor myocytes. | 2001 | BJU Int. | pmid:11350414 |
Oliveira SH et al. | SCF-induced airway hyperreactivity is dependent on leukotriene production. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11350804 |
Snetkov VA et al. | Mechanisms of leukotriene D4-induced constriction in human small bronchioles. | 2001 | Br. J. Pharmacol. | pmid:11350860 |
Bautz F et al. | Chemotaxis and transendothelial migration of CD34(+) hematopoietic progenitor cells induced by the inflammatory mediator leukotriene D4 are mediated by the 7-transmembrane receptor CysLT1. | 2001 | Blood | pmid:11369634 |
Bouchelouche K et al. | Calcium signaling in cultured human detrusor smooth muscle cells from patients with interstitial cystitis. | 2001 | Urology | pmid:11378073 |
Bouchelouche K et al. | Cysteinyl-leukotriene D(4) receptors in smooth muscle cells. | 2001 | Urology | pmid:11378074 |
Nabe T et al. | Comparison of cedar pollen-induced allergic rhinitis in passively and actively sensitized guinea pigs. | 2001 | Jpn. J. Pharmacol. | pmid:11388645 |
Karaman O et al. | The comparison of the efficacy of fluticasone propionate with cetirizine in perennial allergic rhinitis. | 2001 Mar-Apr | Allergol Immunopathol (Madr) | pmid:11420028 |
Ruck LM et al. | Synergistic antiallergic activity of combined histamine H1- and cysteinyl leukotriene1-receptor blockade in human bronchus. | 2001 | Life Sci. | pmid:11432448 |
Möhle R et al. | Transendothelial migration of hematopoietic progenitor cells. Role of chemotactic factors. | 2001 | Ann. N. Y. Acad. Sci. | pmid:11458515 |
Mizutani N et al. | Markedly increased nasal blockage by intranasal leukotriene D4 in an experimental allergic rhinitis model: contribution of dilated mucosal blood vessels. | 2001 | Jpn. J. Pharmacol. | pmid:11459119 |
Echazarreta AL et al. | Pulmonary gas exchange and sputum cellular responses to inhaled leukotriene D(4) in asthma. | 2001 | Am. J. Respir. Crit. Care Med. | pmid:11463588 |
Shi ZZ et al. | Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D(4) synthesis in vivo and attenuation of the acute inflammatory response. | 2001 | Mol. Cell. Biol. | pmid:11463821 |
Bäck M et al. | An alternative pathway for metabolism of leukotriene D(4): effects on contractions to cysteinyl-leukotrienes in the guinea-pig trachea. | 2001 | Br. J. Pharmacol. | pmid:11487525 |