Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Kargman S et al. | Protein kinase C-dependent regulation of sulfidopeptide leukotriene biosynthesis and leukotriene C4 synthase in neutrophilic HL-60 cells. | 1994 | Mol. Pharmacol. | pmid:8190095 |
Herd CM et al. | Effect of a 5-lipoxygenase inhibitor and leukotriene antagonist (PF 5901) on antigen-induced airway responses in neonatally immunized rabbits. | 1994 | Br. J. Pharmacol. | pmid:8032653 |
Mion F et al. | Short term effects of indomethacin on rat small intestinal permeability. Role of eicosanoids and platelet activating factor. | 1994 | Gut | pmid:8174986 |
Salari H et al. | Involvement of immunologic mechanisms in a guinea pig model of western red cedar asthma. | 1994 | J. Allergy Clin. Immunol. | pmid:8182231 |
Ramis I et al. | Application of totally automated on-line sample clean up system for extraction and high-performance liquid chromatography separation of peptide leukotrienes. | 1993 Nov-Dec | J Pharm Biomed Anal | pmid:8123725 |
Schwartz JI et al. | Oral pharmacokinetics and food interaction of the leukotriene D4 receptor antagonist verlukast. | 1993 | Br J Clin Pharmacol | pmid:12959296 |
Khayyal MT et al. | Mechanisms involved in the antiinflammatory effect of propolis extract. | 1993 | Drugs Exp Clin Res | pmid:7513636 |
Yoshikawa S et al. | Modulation of acetylcholine release from the myenteric plexus of guinea-pig ileum by 5-lipoxygenase metabolites of arachidonic acid. | 1993 | Eur. J. Pharmacol. | pmid:8223906 |
Krauss AH and Woodward DF | Polymorphonuclear leukocyte infiltration into the subretinal choroid and optic nerve in response to leukotrienes. | 1993 | Invest. Ophthalmol. Vis. Sci. | pmid:8258528 |
Weide I et al. | Intravascular cysteinyl-leukotriene formation by clotting whole human blood. Evidence from clamped umbilical vein segments and thrombus specimens. | 1993 | Thromb. Res. | pmid:8122190 |
Arakawa H et al. | Leukotriene D4- and prostaglandin F2 alpha-induced airflow obstruction and airway plasma exudation in guinea-pig: role of thromboxane and its receptor. | 1993 | Br. J. Pharmacol. | pmid:8220872 |
Lee TH and Christie PE | Leukotrienes and aspirin induced asthma. | 1993 | Thorax | pmid:8303620 |
Dahlén B et al. | Effect of the leukotriene receptor antagonist MK-0679 on baseline pulmonary function in aspirin sensitive asthmatic subjects. | 1993 | Thorax | pmid:8303624 |
Hyun CS and Binder HJ | Mechanism of leukotriene D4 stimulation of Cl- secretion in rat distal colon in vitro. | 1993 | Am. J. Physiol. | pmid:8214069 |
Pawloski JR and Chapnick BM | Antagonism of LTD4-evoked relaxation in canine renal artery and vein. | 1993 | Am. J. Physiol. | pmid:8214135 |
Manning PJ et al. | Exercise-induced refractoriness in asthmatic subjects involves leukotriene and prostaglandin interdependent mechanisms. | 1993 | Am. Rev. Respir. Dis. | pmid:8214949 |
Smith LJ et al. | Inhibition of leukotriene D4-induced bronchoconstriction in subjects with asthma: a concentration-effect study of ICI 204,219. | 1993 | Clin. Pharmacol. Ther. | pmid:8222486 |
Mastrocola T et al. | Volume regulation in human fibroblasts: role of Ca2+ and 5-lipoxygenase products in the activation of the Cl- efflux. | 1993 | J. Membr. Biol. | pmid:8271272 |
Shikada K and Tanaka S | Influence of epithelium on the inhibition of melittin-induced contraction of guinea-pig isolated trachea by the potassium channel opener NIP-121. | 1993 | Br. J. Pharmacol. | pmid:8401920 |
Metters KM and Zamboni RJ | Photoaffinity labeling of the leukotriene D4 receptor in guinea pig lung. | 1993 | J. Biol. Chem. | pmid:8384212 |
Diener M and Scharrer E | The leukotriene D4 receptor blocker, SK&F 104353, inhibits volume regulation in isolated crypts from the rat distal colon. | 1993 | Eur. J. Pharmacol. | pmid:8405093 |
Nagahisa A et al. | Antiinflammatory and analgesic activity of CP-96,345: an orally active non-peptide substance P receptor antagonist. | 1993 | Regul. Pept. | pmid:7692561 |
Inada T et al. | Intravenous anesthetic propofol suppresses prostaglandin E2 and cysteinyl leukotriene production and reduces edema formation in arachidonic acid-induced ear inflammation. | J Immunotoxicol | pmid:25046027 | |
pmid: | ||||
pmid:25512344 | ||||
pmid:28410666 | ||||
pmid:25707327 | ||||
pmid:25704617 | ||||
pmid:18651869 | ||||
pmid:15888248 | ||||
pmid:28098359 | ||||
pmid:27881050 | ||||
pmid:27666014 | ||||
pmid:26115646 | ||||
pmid:25103494 | ||||
pmid:25090924 | ||||
pmid:24958577 | ||||
pmid:24735655 | ||||
pmid:24506412 | ||||
pmid:9797038 |