Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Ganbo T et al. | Effect of ibudilast on ciliary activity of human paranasal sinus mucosa in vitro. | 1995 | Arzneimittelforschung | pmid:7575753 |
Nakamura S et al. | Effects of 1-[3-(4-benzhydryl-1-piperazinyl)propyl]-3- (1H-imidazol-1-ylmethyl)-1H-indole-6-carboxylic acid with thromboxane A2 synthetase inhibitory and H1-blocking activities on anaphylactic bronchospasm. | 1996 | Arzneimittelforschung | pmid:8955866 |
Kumasawa F et al. | Mitogen-activated protein kinase (MAPK) regulates leukotriene D4-induced HB-EGF and ADAM12 expression in human airway smooth muscle cells. | 2013 | Asian Pac. J. Allergy Immunol. | pmid:23517395 |
Porreca E et al. | Modulation of rat vascular smooth muscle cell (VSMC) proliferation by cysteinyl leukotriene D4: a role for mediation of interleukin 1. | 1995 | Atherosclerosis | pmid:7755646 |
Porreca E et al. | Cysteinyl-leukotriene D4 induced IL-1 beta expression and release in rat vascular smooth muscle cells. | 1995 | Atherosclerosis | pmid:7661877 |
Tada N et al. | Experimental otitis media with effusion induced by leukotriene D4. | 2002 | Auris Nasus Larynx | pmid:11893446 |
Chiba Y et al. | Regional differences in vascular responsiveness of nasal mucosae isolated from naive guinea pigs. | 2007 | Auris Nasus Larynx | pmid:17056219 |
Bai CH et al. | The inhibitory effect of the leukotriene receptor antagonist on leukotriene D4-induced MUC2/5AC gene expression and mucin secretion in human airway epithelial cells. | 2007 | Auris Nasus Larynx | pmid:17223000 |
Hirata F et al. | IL-1 beta regulates the expression of the Gi2 alpha gene via lipid mediators in guinea pig tracheal muscle. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7945342 |
Adolfsson JL et al. | Leukotriene D4-induced activation and translocation of the G-protein alpha i3-subunit in human epithelial cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8806649 |
Wang ML et al. | Leukotriene D4 induces brain edema and enhances CysLT2 receptor-mediated aquaporin 4 expression. | 2006 | Biochem. Biophys. Res. Commun. | pmid:17010308 |
Wikström K et al. | The anti-apoptotic effect of leukotriene D4 involves the prevention of caspase 8 activation and Bid cleavage. | 2003 | Biochem. J. | pmid:12482325 |
Grönroos E et al. | Leukotriene D4-induced mobilization of intracellular Ca2+ in epithelial cells is critically dependent on activation of the small GTP-binding protein Rho. | 1996 | Biochem. J. | pmid:8645211 |
Thodeti CK et al. | Leukotriene D4 induces association of active RhoA with phospholipase C-gamma1 in intestinal epithelial cells. | 2002 | Biochem. J. | pmid:12071848 |
Ravasi S et al. | Pharmacological differences among CysLT(1) receptor antagonists with respect to LTC(4) and LTD(4) in human lung parenchyma. | 2002 | Biochem. Pharmacol. | pmid:11996896 |
Martin V et al. | Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors. | 2001 | Biochem. Pharmacol. | pmid:11705452 |
Capra V et al. | CysLT1 signal transduction in differentiated U937 cells involves the activation of the small GTP-binding protein Ras. | 2004 | Biochem. Pharmacol. | pmid:15041474 |
Nieves D and Moreno JJ | Role of 5-lipoxygenase pathway in the regulation of RAW 264.7 macrophage proliferation. | 2006 | Biochem. Pharmacol. | pmid:16934759 |
Mezhybovska M et al. | Pro-inflammatory mediator leukotriene D4 induces transcriptional activity of potentially oncogenic genes. | 2005 | Biochem. Soc. Trans. | pmid:16042577 |
An S et al. | Molecular cloning of sheep lung dipeptidase: a glycosyl phosphatidylinositol-anchored ectoenzyme that converts leukotriene D4 to leukotriene E4. | 1994 | Biochim. Biophys. Acta | pmid:8054366 |