Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Sloniewsky DE et al. | Leukotriene D4 activates alveolar epithelial Na,K-ATPase and increases alveolar fluid clearance. | 2004 | Am. J. Respir. Crit. Care Med. | pmid:14578215 |
Dupré DJ et al. | Inverse agonist activity of selected ligands of the cysteinyl-leukotriene receptor 1. | 2004 | J. Pharmacol. Exp. Ther. | pmid:14718577 |
Mayatepek E et al. | Synthesis and metabolism of leukotrienes in gamma-glutamyl transpeptidase deficiency. | 2004 | J. Lipid Res. | pmid:14754911 |
Wulff T et al. | Co-expression of mCysLT1 receptors and IK channels in Xenopus laevis oocytes elicits LTD4-stimulated IK current, independent of an increase in [Ca2+]i. | 2004 | Biochim. Biophys. Acta | pmid:14757222 |
Capra V et al. | CysLT1 signal transduction in differentiated U937 cells involves the activation of the small GTP-binding protein Ras. | 2004 | Biochem. Pharmacol. | pmid:15041474 |
Yang G et al. | Transgenic smooth muscle expression of the human CysLT1 receptor induces enhanced responsiveness of murine airways to leukotriene D4. | 2004 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15064240 |
Wooltorton E | Asthma drug zafirlukast (Accolate): serious hepatic events. | 2004 | CMAJ | pmid:15159361 |
Asakura T et al. | Leukotriene D4 stimulates collagen production from myofibroblasts transformed by TGF-beta. | 2004 | J. Allergy Clin. Immunol. | pmid:15316508 |
Zhao L et al. | The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm. | 2004 | Nat. Med. | pmid:15322539 |
Carbajal V et al. | LTD4 induces hyperresponsiveness to histamine in bovine airway smooth muscle: role of SR-ATPase Ca2+ pump and tyrosine kinase. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15377496 |
Tsuji T et al. | Differential effects of beta2-adrenoceptor desensitization on the IgE-dependent release of chemical mediators from cultured human mast cells. | 2004 | Biol. Pharm. Bull. | pmid:15467193 |
Ishinaga H et al. | Pranlukast inhibits NF-kappaB activation and MUC2 gene expression in cultured human epithelial cells. | 2005 | Pharmacology | pmid:15475658 |
Pillai SG et al. | A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma. | 2004 | Pharmacogenetics | pmid:15475736 |
Ferrari F et al. | Pharmacological profile of CR3465, a new leukotriene CysLT1 receptor antagonist with broad anti-inflammatory activity. | 2004 | Eur. J. Pharmacol. | pmid:15541426 |
Nielsen CK et al. | Leukotriene D4 activates distinct G-proteins in intestinal epithelial cells to regulate stress fibre formation and to generate intracellular Ca2+ mobilisation and ERK1/2 activation. | 2005 | Exp. Cell Res. | pmid:15541723 |
Nakanishi Y et al. | Synergism between cysteinyl leukotrienes and thromboxane A2 to induce allergic late phase nasal blockage in guinea pigs. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15560121 |
Naik S et al. | Regulation of cysteinyl leukotriene type 1 receptor internalization and signaling. | 2005 | J. Biol. Chem. | pmid:15590629 |
Saito K et al. | Leukotriene D4 and eosinophil transendothelial migration, superoxide generation, and degranulation via beta2 integrin. | 2004 | Ann. Allergy Asthma Immunol. | pmid:15609771 |
Paruchuri S et al. | The pro-inflammatory mediator leukotriene D4 induces phosphatidylinositol 3-kinase and Rac-dependent migration of intestinal epithelial cells. | 2005 | J. Biol. Chem. | pmid:15657050 |
Nielsen CK et al. | A novel localization of the G-protein-coupled CysLT1 receptor in the nucleus of colorectal adenocarcinoma cells. | 2005 | Cancer Res. | pmid:15705869 |