Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Shikada K and Tanaka S | Effect of the K+ channel openers NIP-121 and cromakalim on melittin-induced relaxation of guinea-pig isolated trachea. | 1996 | Prostaglandins | pmid:8792445 |
Dudek SM and Friedlander MJ | Developmental down-regulation of LTD in cortical layer IV and its independence of modulation by inhibition. | 1996 | Neuron | pmid:8663986 |
Jorgensen NK et al. | Role of LTD4 in the regulatory volume decrease response in Ehrlich ascites tumor cells. | 1996 | J. Membr. Biol. | pmid:8661498 |
Carlton RA et al. | Preparation and characterization of polymorphs for an LTD4 antagonist, RG 12525. | 1996 | J Pharm Sci | pmid:8742935 |
Sakurai S et al. | Synthesis and thromboxane A2 antagonistic activity of [[1-aryl(or benzyl)-1-(benzenesulfonamido)methyl]phenyl]alkanoic acid derivatives. | 1996 | Chem. Pharm. Bull. | pmid:8681409 |
Datta HK et al. | Parathyroid hormone induces superoxide anion burst in the osteoclast: evidence for the direct instantaneous activation of the osteoclast by the hormone. | 1996 | J. Endocrinol. | pmid:8708538 |
Konno A et al. | Role of substance P in the vascular response of nasal mucosa in nasal allergy. | 1996 | Ann. Otol. Rhinol. Laryngol. | pmid:8712637 |
Ishikawa J et al. | Involvement of endogenous tachykinins in LTD4-induced airway responses. | 1996 | Eur. Respir. J. | pmid:8730008 |
Bäck M et al. | The cysteinyl-leukotriene receptor antagonist BAY u9773 is a competitive antagonist of leukotriene C4 in the guinea-pig ileum. | 1996 | Eur. J. Pharmacol. | pmid:8982726 |
Kaminuma O et al. | Inhibitory effect of a novel phosphodiesterase IV inhibitor, T-440, on antigen- and chemical mediator-induced bronchoconstrictions in guinea pigs in vivo. | 1996 | Jpn. J. Pharmacol. | pmid:8902593 |
Burghardt JS et al. | Lipid mediators in oxygen-induced airway remodeling and hyperresponsiveness in newborn rats. | 1996 | Am. J. Respir. Crit. Care Med. | pmid:8887572 |
Underwood DC et al. | Persistent airway eosinophilia after leukotriene (LT) D4 administration in the guinea pig: modulation by the LTD4 receptor antagonist, pranlukast, or an interleukin-5 monoclonal antibody. | 1996 | Am. J. Respir. Crit. Care Med. | pmid:8887574 |
Ochsner M | The action of the peptidoleukotriene LTD4 on intracellular calcium in rat mesangial cells. | 1996 | Experientia | pmid:8841513 |
Abraham WM et al. | Effect of TYB-2285 on antigen-induced airway responses in sheep. | 1996 | Pulm Pharmacol | pmid:8843510 |
Wensing G et al. | Pharmacodynamics and pharmacokinetics of BAY x 7195 aerosol, a new and selective receptor antagonist of cysteinyl-leukotrienes, in normal volunteers. | 1996 | Br J Clin Pharmacol | pmid:8864314 |
Gyömber E et al. | Effect of lipoxygenase inhibitors and leukotriene antagonists on acute and chronic gastric haemorrhagic mucosal lesions in ulcer models in the rat. | 1996 | J. Gastroenterol. Hepatol. | pmid:8912128 |
Nagase T et al. | Roles of calcitonin gene-related peptide (CGRP) in hyperpnea-induced constriction in guinea pigs. | 1996 | Am. J. Respir. Crit. Care Med. | pmid:8912779 |
Gorenne I et al. | Antigen stimulation of human pulmonary smooth muscle: an in vitro model of inflammation. | 1996 | Cell Biol. Toxicol. | pmid:9034615 |
Rajah R et al. | Leukotriene D4 induces MMP-1, which functions as an IGFBP protease in human airway smooth muscle cells. | 1996 | Am. J. Physiol. | pmid:8997273 |
Aizawa H et al. | Thromboxane A2 antagonist inhibits leukotriene D4-induced smooth muscle contraction in guinea-pig lung parenchyma, but not in trachea. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9014223 |