| MeSH term | MeSH ID | Detail |
|---|---|---|
| Endotoxemia | D019446 | 27 associated lipids |
| Respiratory Syncytial Virus Infections | D018357 | 10 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Bronchial Hyperreactivity | D016535 | 15 associated lipids |
| Nasal Obstruction | D015508 | 4 associated lipids |
| Leukemia, Lymphocytic, Chronic, B-Cell | D015451 | 25 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Inflammatory Bowel Diseases | D015212 | 9 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Sneezing | D012912 | 6 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Rhinitis | D012220 | 10 associated lipids |
| Respiratory Hypersensitivity | D012130 | 18 associated lipids |
| Peptic Ulcer Hemorrhage | D010438 | 4 associated lipids |
| Respirovirus Infections | D010253 | 3 associated lipids |
| Otitis Media with Effusion | D010034 | 9 associated lipids |
| Neuralgia | D009437 | 28 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Influenza, Human | D007251 | 11 associated lipids |
LTD4
Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTD4?
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTD4
PubChem Associated disorders and diseases
What pathways are associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTD4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with LTD4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTD4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with LTD4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTD4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTD4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Prinz I et al. | The type 1 cysteinyl leukotriene receptor triggers calcium influx and chemotaxis in mouse alpha beta- and gamma delta effector T cells. | 2005 | J. Immunol. | pmid:16002666 |
| Gauvreau GM et al. | Expression of functional cysteinyl leukotriene receptors by human basophils. | 2005 | J. Allergy Clin. Immunol. | pmid:15990778 |
| Parhamifar L et al. | Activation of cPLA2 is required for leukotriene D4-induced proliferation in colon cancer cells. | 2005 | Carcinogenesis | pmid:15975962 |
| Kumasawa F et al. | Apoptosis signal-regulating kinase 1 in leukotriene D(4)-induced activator protein-1 activation in airway smooth muscle cells. | 2005 | Eur. J. Pharmacol. | pmid:15970283 |
| Kato Y et al. | Leukotriene D4 induces production of transforming growth factor-beta1 by eosinophils. | 2005 | Int. Arch. Allergy Immunol. | pmid:15947480 |
| Nagata M et al. | Effect of the cysteinyl leukotriene antagonist pranlukast on transendothelial migration of eosinophils. | 2005 | Int. Arch. Allergy Immunol. | pmid:15947477 |
| pmid:15888248 | ||||
| Bochner BS and Busse WW | Allergy and asthma. | 2005 | J. Allergy Clin. Immunol. | pmid:15867851 |
| Neves JS et al. | Evaluating the prophylactic potential of the phtalimide derivative LASSBio 552 on allergen-evoked inflammation in rats. | 2005 | Eur. J. Pharmacol. | pmid:15792791 |
| Reims A et al. | Cysteinyl leukotrienes are secretagogues in atrophic coeliac and in normal duodenal mucosa of children. | 2005 | Scand. J. Gastroenterol. | pmid:15764146 |
| Nielsen CK et al. | A novel localization of the G-protein-coupled CysLT1 receptor in the nucleus of colorectal adenocarcinoma cells. | 2005 | Cancer Res. | pmid:15705869 |
| Paruchuri S et al. | The pro-inflammatory mediator leukotriene D4 induces phosphatidylinositol 3-kinase and Rac-dependent migration of intestinal epithelial cells. | 2005 | J. Biol. Chem. | pmid:15657050 |
| Saito K et al. | Leukotriene D4 and eosinophil transendothelial migration, superoxide generation, and degranulation via beta2 integrin. | 2004 | Ann. Allergy Asthma Immunol. | pmid:15609771 |
| Naik S et al. | Regulation of cysteinyl leukotriene type 1 receptor internalization and signaling. | 2005 | J. Biol. Chem. | pmid:15590629 |
| Nakanishi Y et al. | Synergism between cysteinyl leukotrienes and thromboxane A2 to induce allergic late phase nasal blockage in guinea pigs. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15560121 |
| Nielsen CK et al. | Leukotriene D4 activates distinct G-proteins in intestinal epithelial cells to regulate stress fibre formation and to generate intracellular Ca2+ mobilisation and ERK1/2 activation. | 2005 | Exp. Cell Res. | pmid:15541723 |
| Ferrari F et al. | Pharmacological profile of CR3465, a new leukotriene CysLT1 receptor antagonist with broad anti-inflammatory activity. | 2004 | Eur. J. Pharmacol. | pmid:15541426 |
| Pillai SG et al. | A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma. | 2004 | Pharmacogenetics | pmid:15475736 |
| Ishinaga H et al. | Pranlukast inhibits NF-kappaB activation and MUC2 gene expression in cultured human epithelial cells. | 2005 | Pharmacology | pmid:15475658 |
| Tsuji T et al. | Differential effects of beta2-adrenoceptor desensitization on the IgE-dependent release of chemical mediators from cultured human mast cells. | 2004 | Biol. Pharm. Bull. | pmid:15467193 |
| Carbajal V et al. | LTD4 induces hyperresponsiveness to histamine in bovine airway smooth muscle: role of SR-ATPase Ca2+ pump and tyrosine kinase. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15377496 |
| Zhao L et al. | The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm. | 2004 | Nat. Med. | pmid:15322539 |
| Asakura T et al. | Leukotriene D4 stimulates collagen production from myofibroblasts transformed by TGF-beta. | 2004 | J. Allergy Clin. Immunol. | pmid:15316508 |
| Wooltorton E | Asthma drug zafirlukast (Accolate): serious hepatic events. | 2004 | CMAJ | pmid:15159361 |
| Yang G et al. | Transgenic smooth muscle expression of the human CysLT1 receptor induces enhanced responsiveness of murine airways to leukotriene D4. | 2004 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15064240 |
| Capra V et al. | CysLT1 signal transduction in differentiated U937 cells involves the activation of the small GTP-binding protein Ras. | 2004 | Biochem. Pharmacol. | pmid:15041474 |
| Wulff T et al. | Co-expression of mCysLT1 receptors and IK channels in Xenopus laevis oocytes elicits LTD4-stimulated IK current, independent of an increase in [Ca2+]i. | 2004 | Biochim. Biophys. Acta | pmid:14757222 |
| Mayatepek E et al. | Synthesis and metabolism of leukotrienes in gamma-glutamyl transpeptidase deficiency. | 2004 | J. Lipid Res. | pmid:14754911 |
| Dupré DJ et al. | Inverse agonist activity of selected ligands of the cysteinyl-leukotriene receptor 1. | 2004 | J. Pharmacol. Exp. Ther. | pmid:14718577 |
| Sloniewsky DE et al. | Leukotriene D4 activates alveolar epithelial Na,K-ATPase and increases alveolar fluid clearance. | 2004 | Am. J. Respir. Crit. Care Med. | pmid:14578215 |
| Capra V et al. | Involvement of prenylated proteins in calcium signaling induced by LTD4 in differentiated U937 cells. | 2003 | Prostaglandins Other Lipid Mediat. | pmid:14518564 |
| Thompson MD et al. | A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha. | 2003 | Pharmacogenetics | pmid:14515063 |
| Massoumi R et al. | Leukotriene D4-induced adhesion of Caco-2 cells is mediated by prostaglandin E2 and upregulation of alpha2beta1-integrin. | 2003 | Exp. Cell Res. | pmid:14499635 |
| Sugahara S et al. | Kinins are involved in the development of allergic nasal hyperresponsiveness in guinea pigs. | 2003 | Eur. J. Pharmacol. | pmid:12969770 |
| Schwartz JI et al. | Oral pharmacokinetics and food interaction of the leukotriene D4 receptor antagonist verlukast. | 1993 | Br J Clin Pharmacol | pmid:12959296 |
| Sundström E et al. | Interactions among three classes of mediators explain antigen-induced bronchoconstriction in the isolated perfused and ventilated guinea pig lung. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12954791 |
| Paruchuri S and Sjölander A | Leukotriene D4 mediates survival and proliferation via separate but parallel pathways in the human intestinal epithelial cell line Int 407. | 2003 | J. Biol. Chem. | pmid:12912998 |
| Kawano T et al. | Cysteinyl leukotrienes induce nuclear factor kappa b activation and RANTES production in a murine model of asthma. | 2003 | J. Allergy Clin. Immunol. | pmid:12897744 |
| Suzuki M et al. | Inhibition of human eosinophil activation by a cysteinyl leukotriene receptor antagonist (pranlukast; ONO-1078). | 2003 | J Asthma | pmid:12870835 |
| Schuhmann MU et al. | Temporal profiles of cerebrospinal fluid leukotrienes, brain edema and inflammatory response following experimental brain injury. | 2003 | Neurol. Res. | pmid:12866196 |
| Mechiche H et al. | Effects of cysteinyl leukotrienes in small human bronchus and antagonist activity of montelukast and its metabolites. | 2003 | Clin. Exp. Allergy | pmid:12859443 |
| Potter-Perigo S et al. | Regulation of proteoglycan synthesis by leukotriene d4 and epidermal growth factor in bronchial smooth muscle cells. | 2004 | Am. J. Respir. Cell Mol. Biol. | pmid:12855404 |
| Bouchelouche K et al. | The cysteinyl-leukotriene D4 induces cytosolic Ca2+ elevation and contraction of the human detrusor muscle. | 2003 | J. Urol. | pmid:12853847 |
| Sylvin H et al. | Cysteinyl leukotrienes in porcine acute allergic airway reactions: bronchial and vascular effects. | 2003 | Inflamm. Res. | pmid:12813622 |
| Ichiyama T et al. | Pranlukast inhibits NF-kappa B activation in human monocytes/macrophages and T cells. | 2003 | Clin. Exp. Allergy | pmid:12801316 |
| Vargaftig BB and Singer M | Leukotrienes mediate part of Ova-induced lung effects in mice via EGFR. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12794006 |
| Murray J et al. | Role of leukotrienes in the regulation of human granulocyte behaviour: dissociation between agonist-induced activation and retardation of apoptosis. | 2003 | Br. J. Pharmacol. | pmid:12770944 |
| Espinosa K et al. | CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4. | 2003 | J. Allergy Clin. Immunol. | pmid:12743568 |
| Crimi N et al. | Inhibitory effect of a leukotriene receptor antagonist (montelukast) on neurokinin A-induced bronchoconstriction. | 2003 | J. Allergy Clin. Immunol. | pmid:12704366 |
| Soberman RJ and Christmas P | The organization and consequences of eicosanoid signaling. | 2003 | J. Clin. Invest. | pmid:12697726 |