| MeSH term | MeSH ID | Detail |
|---|---|---|
| Airway Obstruction | D000402 | 13 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Inflammatory Bowel Diseases | D015212 | 9 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
| Rhinitis | D012220 | 10 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Glomerulonephritis | D005921 | 35 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
LTD4
Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTD4?
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTD4
PubChem Associated disorders and diseases
What pathways are associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTD4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTD4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTD4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTD4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTD4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTD4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jorgensen NK et al. | Role of LTD4 in the regulatory volume decrease response in Ehrlich ascites tumor cells. | 1996 | J. Membr. Biol. | pmid:8661498 |
| Carlton RA et al. | Preparation and characterization of polymorphs for an LTD4 antagonist, RG 12525. | 1996 | J Pharm Sci | pmid:8742935 |
| Sakurai S et al. | Synthesis and thromboxane A2 antagonistic activity of [[1-aryl(or benzyl)-1-(benzenesulfonamido)methyl]phenyl]alkanoic acid derivatives. | 1996 | Chem. Pharm. Bull. | pmid:8681409 |
| Datta HK et al. | Parathyroid hormone induces superoxide anion burst in the osteoclast: evidence for the direct instantaneous activation of the osteoclast by the hormone. | 1996 | J. Endocrinol. | pmid:8708538 |
| Konno A et al. | Role of substance P in the vascular response of nasal mucosa in nasal allergy. | 1996 | Ann. Otol. Rhinol. Laryngol. | pmid:8712637 |
| Ishikawa J et al. | Involvement of endogenous tachykinins in LTD4-induced airway responses. | 1996 | Eur. Respir. J. | pmid:8730008 |
| Hisamatsu K et al. | Effect of leukotriene C4 exposure on ciliated cells of the nasal mucosa. | 1996 | Prostaglandins | pmid:8900445 |
| Kaminuma O et al. | Inhibitory effect of a novel phosphodiesterase IV inhibitor, T-440, on antigen- and chemical mediator-induced bronchoconstrictions in guinea pigs in vivo. | 1996 | Jpn. J. Pharmacol. | pmid:8902593 |
| Fukai F et al. | Transcellular biosynthesis of cysteinyl leukotrienes by Kupffer cell-hepatocyte cooperation in rat liver. | 1996 | Cell Biol. Int. | pmid:8858827 |
| Underwood DC et al. | Persistent airway eosinophilia after leukotriene (LT) D4 administration in the guinea pig: modulation by the LTD4 receptor antagonist, pranlukast, or an interleukin-5 monoclonal antibody. | 1996 | Am. J. Respir. Crit. Care Med. | pmid:8887574 |
| Ochsner M | The action of the peptidoleukotriene LTD4 on intracellular calcium in rat mesangial cells. | 1996 | Experientia | pmid:8841513 |
| Abraham WM et al. | Effect of TYB-2285 on antigen-induced airway responses in sheep. | 1996 | Pulm Pharmacol | pmid:8843510 |
| Wensing G et al. | Pharmacodynamics and pharmacokinetics of BAY x 7195 aerosol, a new and selective receptor antagonist of cysteinyl-leukotrienes, in normal volunteers. | 1996 | Br J Clin Pharmacol | pmid:8864314 |
| Tai S et al. | Effect of leukotriene D4 on tracheal mucociliary transport velocity in quails. | 1996 | Jpn. J. Pharmacol. | pmid:8866758 |
| Martin CA et al. | In vitro pharmacological effects of S 12370 (2-[4-benzhydryloxypiperidinoethyl]isoxindole; an antibronchoconstrictor agent) in normal and sensitized tissue. | 1996 | Fundam Clin Pharmacol | pmid:8902549 |
| Omori C et al. | Eicosanoids modulate hyperpnea-induced bronchoconstriction in canine peripheral airways. | 1996 | J. Appl. Physiol. | pmid:8889761 |
| Chong K et al. | Drug substance manufacture process control: application of flow injection analysis and HPLC for monitoring an enantiospecific synthesis. | 1996 | J Pharm Biomed Anal | pmid:8895082 |
| Nakamura S et al. | Effects of 1-[3-(4-benzhydryl-1-piperazinyl)propyl]-3- (1H-imidazol-1-ylmethyl)-1H-indole-6-carboxylic acid with thromboxane A2 synthetase inhibitory and H1-blocking activities on anaphylactic bronchospasm. | 1996 | Arzneimittelforschung | pmid:8955866 |
| Heimbürger M and Palmblad JE | Effects of leukotriene C4 and D4, histamine and bradykinin on cytosolic calcium concentrations and adhesiveness of endothelial cells and neutrophils. | 1996 | Clin. Exp. Immunol. | pmid:8608646 |
| Garcia C et al. | Effects of synthetic peptido-leukotrienes on bone resorption in vitro. | 1996 | J. Bone Miner. Res. | pmid:8992883 |
| Adolfsson JL et al. | Leukotriene D4-induced activation and translocation of the G-protein alpha i3-subunit in human epithelial cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8806649 |
| Nagase T et al. | Airway and tissue behavior during early response in sensitized rats: role of 5-HT and LTD4. | 1996 | J. Appl. Physiol. | pmid:8929602 |
| Hazel BA et al. | Induction of granulocytic differentiation in a mouse model by benzene and hydroquinone. | 1996 | Environ. Health Perspect. | pmid:9118902 |
| Gorenne I et al. | Antigen stimulation of human pulmonary smooth muscle: an in vitro model of inflammation. | 1996 | Cell Biol. Toxicol. | pmid:9034615 |
| Rajah R et al. | Leukotriene D4 induces MMP-1, which functions as an IGFBP protease in human airway smooth muscle cells. | 1996 | Am. J. Physiol. | pmid:8997273 |
| Aizawa H et al. | Thromboxane A2 antagonist inhibits leukotriene D4-induced smooth muscle contraction in guinea-pig lung parenchyma, but not in trachea. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9014223 |
| Joki S et al. | Effect of leukotriene D4 on ciliary activity in human, guinea-pig and rat respiratory mucosa. | 1996 | Pulm Pharmacol | pmid:9160411 |
| Papayianni A et al. | Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells. | 1996 | J. Immunol. | pmid:8690917 |
| Kang BC et al. | Experimental asthma developed by room air contamination with cockroach allergen. | 1996 | Int. Arch. Allergy Immunol. | pmid:8917126 |
| Funayama T et al. | Role of Leukotriene-degrading enzymes in pulmonary response to antigen infusion in sensitized guinea pigs in vivo. | 1996 | Am. J. Respir. Cell Mol. Biol. | pmid:8703483 |
| Grönroos E et al. | Leukotriene D4-induced mobilization of intracellular Ca2+ in epithelial cells is critically dependent on activation of the small GTP-binding protein Rho. | 1996 | Biochem. J. | pmid:8645211 |
| Hendeles L and Marshik PL | Zileuton: a new therapy for asthma or just the first of a new class of drugs. | 1996 Jul-Aug | Ann Pharmacother | pmid:8826576 |
| Sampson SE et al. | Effect of inhaled prostaglandin D2 in normal and atopic subjects, and of pretreatment with leukotriene D4. | 1997 | Thorax | pmid:9227716 |
| Beckh K et al. | Impairment of hepatic transport processes in perfused rat liver by the specific CCK receptor antagonist loxiglumide. | 1997 | Res Exp Med (Berl) | pmid:9406280 |
| Fujita M et al. | Cysteinyl leukotrienes induce nasal symptoms of allergic rhinitis via a receptor-mediated mechanism in guinea pigs. | 1997 | Jpn. J. Pharmacol. | pmid:9469641 |
| Beckh K et al. | Effects of nitric oxide on leukotriene D4 decreased bile secretion in the perfused rat liver. | 1997 | Life Sci. | pmid:9364199 |
| Kagoshima M et al. | Effect of Y-24180, a long-acting antagonist to platelet-activating factor (PAF), on PAF-induced reactions: a relationship between the partial structure of the compound and its duration of the action. | 1997 | Pharmacology | pmid:9380772 |
| Cincu RN et al. | S-adenosyl-L-methionine protects the liver against the cholestatic, cytotoxic, and vasoactive effects of leukotriene D4: a study with isolated and perfused rat liver. | 1997 | Hepatology | pmid:9252142 |
| Goldhill J et al. | Interleukin-4 modulates cholinergic neural control of mouse small intestinal longitudinal muscle. | 1997 | Am. J. Physiol. | pmid:9176223 |
| Sakurai S et al. | Synthesis and dual antagonistic activity against thromboxane A2 and leukotriene D4 of [4-[1-(benzenesulfonamido)alkyl]phenyl]alkanoic acid derivatives. | 1997 | Chem. Pharm. Bull. | pmid:9178522 |
| Spector SL | Leukotriene activity modulation in asthma. | 1997 | Drugs | pmid:9279501 |
| Gissurarson SR et al. | Effect of lobaric acid on cysteinyl-leukotriene formation and contractile activity of guinea pig taenia coli. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9023290 |
| Diamant Z et al. | The effect of inhaled leukotriene D4 and methacholine on sputum cell differentials in asthma. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9105062 |
| Pedersen S et al. | Leukotriene D4-induced Ca2+ mobilization in Ehrlich ascites tumor cells. | 1997 | J. Membr. Biol. | pmid:9002425 |
| Kubes P | Nitric oxide and microvascular permeability: a continuing dilemma. | 1997 | Eur. Respir. J. | pmid:9032483 |
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| Tvaermose-Nielsen O et al. | Discovery of OT4003, a novel, potent, and orally active cys-LT1 receptor antagonist. | 1997 | Bioorg. Med. Chem. | pmid:9061206 |
| Ohd JF et al. | Leukotriene D4-induced signalling events in human epithelial cells: G alpha i3 activation and translocation. | 1997 | Adv. Exp. Med. Biol. | pmid:9561113 |
| von Sprecher A et al. | CGP57698: a structurally simple, highly potent peptido-leukotriene (pLT) antagonist of the quinoline type. | 1997 | Adv. Exp. Med. Biol. | pmid:9561127 |
| Muñoz NM et al. | Eosinophil chemotaxis inhibited by 5-lipoxygenase blockade and leukotriene receptor antagonism. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9105085 |