LTD4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTD4?

LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTD4

MeSH term MeSH ID Detail
Airway Obstruction D000402 13 associated lipids
Stomach Ulcer D013276 75 associated lipids
Adenocarcinoma D000230 166 associated lipids
Inflammation D007249 119 associated lipids
Inflammatory Bowel Diseases D015212 9 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Gastritis D005756 27 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTD4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTD4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTD4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTD4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTD4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTD4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTD4

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Authors Title Published Journal PubMed Link
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Inada T et al. Intravenous anesthetic propofol suppresses prostaglandin E2 and cysteinyl leukotriene production and reduces edema formation in arachidonic acid-induced ear inflammation. J Immunotoxicol pmid:25046027
pmid:
Schwartz JI et al. Oral pharmacokinetics and food interaction of the leukotriene D4 receptor antagonist verlukast. 1993 Br J Clin Pharmacol pmid:12959296
Khayyal MT et al. Mechanisms involved in the antiinflammatory effect of propolis extract. 1993 Drugs Exp Clin Res pmid:7513636
Yoshikawa S et al. Modulation of acetylcholine release from the myenteric plexus of guinea-pig ileum by 5-lipoxygenase metabolites of arachidonic acid. 1993 Eur. J. Pharmacol. pmid:8223906
Krauss AH and Woodward DF Polymorphonuclear leukocyte infiltration into the subretinal choroid and optic nerve in response to leukotrienes. 1993 Invest. Ophthalmol. Vis. Sci. pmid:8258528
Weide I et al. Intravascular cysteinyl-leukotriene formation by clotting whole human blood. Evidence from clamped umbilical vein segments and thrombus specimens. 1993 Thromb. Res. pmid:8122190
Arakawa H et al. Leukotriene D4- and prostaglandin F2 alpha-induced airflow obstruction and airway plasma exudation in guinea-pig: role of thromboxane and its receptor. 1993 Br. J. Pharmacol. pmid:8220872
Lee TH and Christie PE Leukotrienes and aspirin induced asthma. 1993 Thorax pmid:8303620
Dahlén B et al. Effect of the leukotriene receptor antagonist MK-0679 on baseline pulmonary function in aspirin sensitive asthmatic subjects. 1993 Thorax pmid:8303624
Hyun CS and Binder HJ Mechanism of leukotriene D4 stimulation of Cl- secretion in rat distal colon in vitro. 1993 Am. J. Physiol. pmid:8214069
Pawloski JR and Chapnick BM Antagonism of LTD4-evoked relaxation in canine renal artery and vein. 1993 Am. J. Physiol. pmid:8214135
Manning PJ et al. Exercise-induced refractoriness in asthmatic subjects involves leukotriene and prostaglandin interdependent mechanisms. 1993 Am. Rev. Respir. Dis. pmid:8214949
Smith LJ et al. Inhibition of leukotriene D4-induced bronchoconstriction in subjects with asthma: a concentration-effect study of ICI 204,219. 1993 Clin. Pharmacol. Ther. pmid:8222486
Mastrocola T et al. Volume regulation in human fibroblasts: role of Ca2+ and 5-lipoxygenase products in the activation of the Cl- efflux. 1993 J. Membr. Biol. pmid:8271272
Shikada K and Tanaka S Influence of epithelium on the inhibition of melittin-induced contraction of guinea-pig isolated trachea by the potassium channel opener NIP-121. 1993 Br. J. Pharmacol. pmid:8401920
Metters KM and Zamboni RJ Photoaffinity labeling of the leukotriene D4 receptor in guinea pig lung. 1993 J. Biol. Chem. pmid:8384212
Diener M and Scharrer E The leukotriene D4 receptor blocker, SK&F 104353, inhibits volume regulation in isolated crypts from the rat distal colon. 1993 Eur. J. Pharmacol. pmid:8405093
Nagahisa A et al. Antiinflammatory and analgesic activity of CP-96,345: an orally active non-peptide substance P receptor antagonist. 1993 Regul. Pept. pmid:7692561
Ramis I et al. Application of totally automated on-line sample clean up system for extraction and high-performance liquid chromatography separation of peptide leukotrienes. 1993 Nov-Dec J Pharm Biomed Anal pmid:8123725
Sparatore A and Sparatore F Preparation and pharmacological activities of 10-homolupinanoyl-2-R-phenothiazines. 1994 Farmaco pmid:7910463
Nishida T et al. Effects of leukotriene D4 on myocardial blood flow and high energy phosphate concentration in anesthetized dogs. 1994 Jpn. Circ. J. pmid:7967000
Hoheisel U and Mense S Leukotriene D4 depresses the mechanosensitivity of group III and IV muscle receptors in the rat. 1994 Neuroreport pmid:8025261
Hirata F et al. IL-1 beta regulates the expression of the Gi2 alpha gene via lipid mediators in guinea pig tracheal muscle. 1994 Biochem. Biophys. Res. Commun. pmid:7945342
Ichinose M et al. Antigen-induced airway responses are inhibited by a potassium channel opener. 1994 Am. J. Respir. Crit. Care Med. pmid:7519521
Javed NH et al. Enhanced tissue responsiveness in colonic ion transport of cow's milk-sensitized guinea pigs. 1994 Agents Actions pmid:7521569
Undem BJ et al. Recombinant stem cell factor-induced mast cell activation and smooth muscle contraction in human bronchi. 1994 Am. J. Respir. Cell Mol. Biol. pmid:7524570
Tudhope SR et al. BAY u9773, a novel antagonist of cysteinyl-leukotrienes with activity against two receptor subtypes. 1994 Eur. J. Pharmacol. pmid:7698171
Spada CS et al. Comparison of leukotriene B4 and D4 effects on human eosinophil and neutrophil motility in vitro. 1994 J. Leukoc. Biol. pmid:8301215
Krauss AH et al. Determination of leukotriene effects on human neutrophil chemotaxis in vitro by differential assessment of cell motility and polarity. 1994 J. Leukoc. Biol. pmid:8301217
Ibe BO et al. Plasma and urinary leukotrienes in sickle cell disease: possible role in the inflammatory process. 1994 Eur. J. Clin. Invest. pmid:8187808
Kargman S et al. Protein kinase C-dependent regulation of sulfidopeptide leukotriene biosynthesis and leukotriene C4 synthase in neutrophilic HL-60 cells. 1994 Mol. Pharmacol. pmid:8190095
Fauler J et al. Enhanced synthesis of cysteinyl leukotrienes in juvenile rheumatoid arthritis. 1994 Arthritis Rheum. pmid:8129769
Nabe T et al. Inhibitory effect of ONO-1078 on specific binding of peptide leukotrienes to human lung crude membrane. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:7824530
Sjölander A and Grönroos E Leukotriene D4-induced signal transduction. 1994 Ann. N. Y. Acad. Sci. pmid:7825836
Krell RD et al. Preclinical exploration of the potential antiinflammatory properties of the peptide leukotriene antagonist ICI 204,219 (Accolate). 1994 Ann. N. Y. Acad. Sci. pmid:7825851
Wensing G et al. Effect of BAY x 7195, an oral receptor antagonist of cysteinyl-leukotrienes, on leukotriene D4-induced bronchoconstriction in normal volunteers. 1994 Eur. J. Clin. Pharmacol. pmid:7867675
Nakazawa T et al. Leukotriene D4-induced mucosal damage during long observation periods in vitro. 1994 Prostaglandins pmid:8066186
Petric R and Ford-Hutchinson AW Elevated cysteinyl leukotriene excretion in experimental glomerulonephritis. 1994 Kidney Int. pmid:7853790
Leier I et al. The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. 1994 J. Biol. Chem. pmid:7961706
An S et al. Molecular cloning of sheep lung dipeptidase: a glycosyl phosphatidylinositol-anchored ectoenzyme that converts leukotriene D4 to leukotriene E4. 1994 Biochim. Biophys. Acta pmid:8054366
Tsopanoglou NE et al. Leukotrienes C4 and D4 promote angiogenesis via a receptor-mediated interaction. 1994 Eur. J. Pharmacol. pmid:7523148
Callaghan DH et al. Respiratory tract eicosanoid measurement using microdialysis sampling and GC/MS detection. 1994 Pulm Pharmacol pmid:8003850
Dandurand RJ et al. In vitro allergic bronchoconstriction in the brown Norway rat. 1994 Am. J. Respir. Crit. Care Med. pmid:8004305
Underwood DC et al. Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs. 1994 J. Pharmacol. Exp. Ther. pmid:8035322
Metters KM et al. Characterization of specific binding sites for cysteinyl leukotrienes in sheep lung. 1994 J. Pharmacol. Exp. Ther. pmid:8035338
Diener M and Scharrer E The effect of short-chain fatty acids on Cl- and K+ conductance in rat colonic crypts. 1994 Pflugers Arch. pmid:8052516
Chan CC et al. Evaluation of bronchoconstriction induced by neurokinins and its inhibition by selective nonpeptide antagonists in conscious guinea pigs, using a double-chamber plethysmograph technique. 1994 Can. J. Physiol. Pharmacol. pmid:8012892
Diamant Z et al. Effect of an inhaled neutral endopeptidase inhibitor, thiorphan, on airway responsiveness to leukotriene D4 in normal and asthmatic subjects. 1994 Eur. Respir. J. pmid:8013602
Chan CC et al. Leukotriene D4-induced increases in cytosolic calcium in THP-1 cells: dependence on extracellular calcium and inhibition with selective leukotriene D4 receptor antagonists. 1994 J. Pharmacol. Exp. Ther. pmid:8014876
Arakawa H et al. Effect of maturation on airway plasma exudation induced by eicosanoids in guinea pig. 1994 Eur. J. Pharmacol. pmid:7982451
Kelley M et al. Induction of peroxisomal enzymes by a tetrazole-substituted 2-quinolinylmethoxy leukotriene D4 antagonist. 1994 Fundam Appl Toxicol pmid:7982537
Ellis JL and Undem BJ Role of cysteinyl-leukotrienes and histamine in mediating intrinsic tone in isolated human bronchi. 1994 Am. J. Respir. Crit. Care Med. pmid:8111568
Welch MJ et al. Effect of RG 12525, a new leukotriene antagonist, on pulmonary function of asthmatic adults. 1994 Ann Allergy pmid:8154635
Dahlén B et al. The leukotriene-antagonist ICI-204,219 inhibits the early airway reaction to cumulative bronchial challenge with allergen in atopic asthmatics. 1994 Eur. Respir. J. pmid:8162986
Han H et al. Effects of LTD4 and its specific antagonist L-660,711 in isolated rat hearts with chronic myocardial infarction. 1994 Am. J. Physiol. pmid:8203604
Tudorić N et al. Phosphoramidon augments contraction of guinea pig tracheal smooth muscle induced by histamine and leukotriene-D4. 1994 Int. Arch. Allergy Immunol. pmid:8111247
Abela A and Daniel EE Neural and myogenic effects of leukotrienes C4, D4, and E4 on canine bronchial smooth muscle. 1994 Am. J. Physiol. pmid:8179018
Kurosawa M et al. Inhibition by a novel peptide leukotriene receptor antagonist ONO-1078 of airway wall thickening and airway hyperresponsiveness to histamine induced by leukotriene C4 or leukotriene D4 in guinea-pigs. 1994 Clin. Exp. Allergy pmid:7842366
Oliva D et al. Correlation between leukotriene D4-induced contraction and cytosolic calcium elevation: a quantitative and simultaneous evaluation in smooth muscle. 1994 J. Pharmacol. Exp. Ther. pmid:8301553
Howell RE et al. Leukotrienes mediate antigen-induced airway hyper-reactivity in guinea pigs. 1994 J. Pharmacol. Exp. Ther. pmid:8301576
Helvering LM et al. H-ras 61st codon activation in archival proliferative hepatic lesions isolated from female B6C3F1 mice exposed to the leukotriene D4-antagonist, LY171883. 1994 Carcinogenesis pmid:8313527
Inamura T et al. Differential tissue expression of immunoreactive dehydropeptidase I, a peptidyl leukotriene metabolizing enzyme. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:8171072
Herd CM et al. Effect of a 5-lipoxygenase inhibitor and leukotriene antagonist (PF 5901) on antigen-induced airway responses in neonatally immunized rabbits. 1994 Br. J. Pharmacol. pmid:8032653
Nathan RA et al. Inhaled ICI 204,219 blocks antigen-induced bronchoconstriction in subjects with bronchial asthma. 1994 Chest pmid:8306751
Thioudellet C et al. Molecular and functional characterization of recombinant human gamma-glutamyltransferase. Coupling of its activity to glutathione levels in V79 cells. 1994 Eur. J. Biochem. pmid:7913033
Mion F et al. Short term effects of indomethacin on rat small intestinal permeability. Role of eicosanoids and platelet activating factor. 1994 Gut pmid:8174986
Salari H et al. Involvement of immunologic mechanisms in a guinea pig model of western red cedar asthma. 1994 J. Allergy Clin. Immunol. pmid:8182231
Kano M Calcium-induced long-lasting potentiation of GABAergic currents in cerebellar Purkinje cells. 1994 Jpn. J. Physiol. pmid:7752516
Sanz ML et al. Modulation of beta 2-adrenoceptors in human lymphocytes by in vitro stimulation with mediators. 1994 May-Jun J Investig Allergol Clin Immunol pmid:7526943
Furukawa K et al. Simplified sulfidoleukotriene ELISA using LTD4-conjugated phosphatase for the study of allergen-induced leukotriene generation by isolated mononuclear cells and diluted whole blood. 1994 May-Jun J Investig Allergol Clin Immunol pmid:7981880
Georgitis JW et al. Chronic sinusitis: characterization of cellular influx and inflammatory mediators in sinus lavage fluid. 1995 Int. Arch. Allergy Immunol. pmid:7719157
Szarek JL and Valentovic MA Release of prostaglandin E2 and leukotriene C4/D4 from airway segments isolated from rats after exposure to ozone for 20 months. 1995 Toxicology pmid:7624868
Conroy DM et al. Relaxant effects of pituitary adenylate cyclase activating polypeptide (PACAP) on epithelium-intact and -denuded guinea-pig trachea: a comparison with vasoactive intestinal peptide (VIP). 1995 Neuropeptides pmid:8538872
Howell RE et al. Pulmonary pharmacology of WAY-126299A: a dual-acting 5-lipoxygenase inhibitor and leukotriene D4 antagonist. 1995 Inflamm. Res. pmid:8548382
Chen C et al. Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC gamma mutant mice. 1995 Cell pmid:8548809
Wettstein M et al. Metabolism of cysteinyl leukotrienes in the perfused rat liver: the influence of endotoxin pretreatment and the cellular hydration state. 1995 Hepatology pmid:7601416
Meier HL et al. Simultaneous initiation of degranulation and inhibition of leukotriene release by soman in human basophils. 1995 Int. J. Immunopharmacol. pmid:7545649
Nasuhara Y et al. [Acyclovir and guinea-pig airway smooth muscle]. 1995 Nihon Kyobu Shikkan Gakkai Zasshi pmid:7563998
Iwamoto I et al. Effect of a selective thromboxane A2 receptor antagonist BAY u3405 on antigen-, leukotriene C4- and leukotriene D4-induced bronchoconstriction in guinea pigs. 1995 Int. Arch. Allergy Immunol. pmid:7647588
Kelefiotis D et al. Eicosanoid-induced growth and signaling events in rat glomerular mesangial cells. 1995 Prostaglandins pmid:7659782
Fiorucci S et al. Effect of NSAIDs on pepsinogen secretion and calcium mobilization in isolated chief cells. 1995 Am. J. Physiol. pmid:7611418
Herron DK et al. Visualization and comparison of molecular dynamics simulations of leukotriene C4, leukotriene D4, and leukotriene E4. 1995 J Mol Graph pmid:8820302
Ganbo T et al. The effects of leukotrienes C4 and D4 on ciliary activity of human paranasal sinus mucosa in vitro. 1995 Rhinology pmid:8919211