| MeSH term | MeSH ID | Detail |
|---|---|---|
| Airway Obstruction | D000402 | 13 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Inflammatory Bowel Diseases | D015212 | 9 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
LTD4
Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTD4?
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTD4
PubChem Associated disorders and diseases
What pathways are associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTD4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTD4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTD4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTD4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTD4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTD4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kondeti V et al. | Leukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3. | 2016 | J. Allergy Clin. Immunol. | pmid:26255103 |
| Rael E | Unraveling the complexity of leukotriene and prostaglandin inflammatory signaling. | 2016 | J. Allergy Clin. Immunol. | pmid:26518091 |
| Lukic A et al. | Pulmonary epithelial cancer cells and their exosomes metabolize myeloid cell-derived leukotriene C4 to leukotriene D4. | 2016 | J. Lipid Res. | pmid:27436590 |
| Khaddaj-Mallat R et al. | Pro-Resolving Effects of Resolvin D2 in LTD4 and TNF-α Pre-Treated Human Bronchi. | 2016 | PLoS ONE | pmid:27935998 |
| Bellamkonda K et al. | The eicosanoids leukotriene D4 and prostaglandin E2 promote the tumorigenicity of colon cancer-initiating cells in a xenograft mouse model. | 2016 | BMC Cancer | pmid:27388564 |
| Park SY et al. | Dehydropeptidase 1 promotes metastasis through regulation of E-cadherin expression in colon cancer. | 2016 | Oncotarget | pmid:26824987 |
| Bellamkonda K et al. | The impact of inflammatory lipid mediators on colon cancer-initiating cells. | 2015 | Mol. Carcinog. | pmid:25154976 |
| Al-Husseini A et al. | Increased eicosanoid levels in the Sugen/chronic hypoxia model of severe pulmonary hypertension. | 2015 | PLoS ONE | pmid:25785937 |
| Xiao J et al. | Cyclooxygenase-1 serves a vital hepato-protective function in chemically induced acute liver injury. | 2015 | Toxicol. Sci. | pmid:25432964 |
| Sekioka T et al. | Expression of CysLT2 receptors in asthma lung, and their possible role in bronchoconstriction. | 2015 | Allergol Int | pmid:26433531 |
| Noguchi T et al. | Effect of beta2-adrenergic agonists on eosinophil adhesion, superoxide anion generation, and degranulation. | 2015 | Allergol Int | pmid:26344080 |
| Al-Azzam N et al. | Modulation of mast cell proliferative and inflammatory responses by leukotriene d4 and stem cell factor signaling interactions. | 2015 | J. Cell. Physiol. | pmid:25161061 |
| O'Brien E et al. | Bisphenol A at concentrations relevant to human exposure enhances histamine and cysteinyl leukotriene release from bone marrow-derived mast cells. | 2014 Jan-Mar | J Immunotoxicol | pmid:23782309 |
| Capra V and Rovati GE | Rosuvastatin inhibits human airway smooth muscle cells mitogenic response to eicosanoid contractile agents. | 2014 | Pulm Pharmacol Ther | pmid:23806820 |
| Salim T et al. | The inflammatory mediator leukotriene D₄ induces subcellular β-catenin translocation and migration of colon cancer cells. | 2014 | Exp. Cell Res. | pmid:24211746 |
| Yu SY et al. | Cysteinyl leukotriene receptor 1 mediates LTD4-induced activation of mouse microglial cells in vitro. | 2014 | Acta Pharmacol. Sin. | pmid:24141567 |
| Mills K et al. | Vitamin E, γ-tocopherol, diminishes ex vivo basophil response to dust mite allergen. | 2014 | Allergy | pmid:24697338 |
| Kawakami Y et al. | Neutralization of leukotriene C4 and D4 activity by monoclonal and single-chain antibodies. | 2014 | Biochim. Biophys. Acta | pmid:24361619 |
| Bukiya AN et al. | Activation of calcium- and voltage-gated potassium channels of large conductance by leukotriene B4. | 2014 | J. Biol. Chem. | pmid:25371198 |
| Linares Segovia B et al. | Parameters of lung inflammation in asthmatic as compared to healthy children in a contaminated city. | 2014 | BMC Pulm Med | pmid:25000942 |
| Arthur S and Sundaram U | Protein kinase C-mediated phosphorylation of RKIP regulates inhibition of Na-alanine cotransport by leukotriene D(4) in intestinal epithelial cells. | 2014 | Am. J. Physiol., Cell Physiol. | pmid:25231108 |
| Minobe E et al. | A new phosphorylation site in cardiac L-type Ca2+ channels (Cav1.2) responsible for its cAMP-mediated modulation. | 2014 | Am. J. Physiol., Cell Physiol. | pmid:25209265 |
| Cosentino S et al. | Expression of dual nucleotides/cysteinyl-leukotrienes receptor GPR17 in early trafficking of cardiac stromal cells after myocardial infarction. | 2014 | J. Cell. Mol. Med. | pmid:24909956 |
| Syslová K et al. | Immunomagnetic molecular probe with UHPLC-MS/MS: a promising way for reliable bronchial asthma diagnostics based on quantification of cysteinyl leukotrienes. | 2013 Jul-Aug | J Pharm Biomed Anal | pmid:23644905 |
| Tang SS et al. | Leukotriene D4 induces cognitive impairment through enhancement of CysLT₠R-mediated amyloid-β generation in mice. | 2013 | Neuropharmacology | pmid:22982445 |
| Jørgensen ST et al. | Double mutation at the putative protein kinase C phosphorylation sites Thr151 plus Thr323 in the mouse leukotrieneD4 receptor eliminates homologous desensitization. | 2013 | Cell. Physiol. Biochem. | pmid:23485744 |
| Germain AR et al. | Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23403082 |
| Zhang Z et al. | [Leukotriene D4 activates BV2 microglia in vitro]. | 2013 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:23801612 |
| Doherty TA et al. | Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production. | 2013 | J. Allergy Clin. Immunol. | pmid:23688412 |
| Matsuse H et al. | Differential airway inflammatory responses in asthma exacerbations induced by respiratory syncytial virus and influenza virus a. | 2013 | Int. Arch. Allergy Immunol. | pmid:23689185 |
| Wan D et al. | The effects of montelukast on eosinophilic gastroenteritis in a mouse model. | 2013 | Immunopharmacol Immunotoxicol | pmid:23240855 |
| Wang XY et al. | Leukotriene D4 induces amyloid-β generation via CysLT(1)R-mediated NF-κB pathways in primary neurons. | 2013 | Neurochem. Int. | pmid:23318673 |
| Celik D et al. | Cysteinyl leukotrienes in exhaled breath condensate of smoking asthmatics. | 2013 | Clin. Chem. Lab. Med. | pmid:23045385 |
| Guan W et al. | Leukotriene D4 and methacholine bronchial provocation tests for identifying leukotriene-responsiveness subtypes. | 2013 | J. Allergy Clin. Immunol. | pmid:23040886 |
| RodrÃguez-Lagunas MJ et al. | 5-Hydroxyeicosatetraenoic acid and leukotriene D4 increase intestinal epithelial paracellular permeability. | 2013 | Int. J. Biochem. Cell Biol. | pmid:23583294 |
| Kumasawa F et al. | Mitogen-activated protein kinase (MAPK) regulates leukotriene D4-induced HB-EGF and ADAM12 expression in human airway smooth muscle cells. | 2013 | Asian Pac. J. Allergy Immunol. | pmid:23517395 |
| Ramos-RamÃrez P et al. | Antigen-induced airway hyperresponsiveness in absence of broncho-obstruction in sensitized guinea pigs. | 2013 | Exp. Lung Res. | pmid:23527782 |
| Kouyama S et al. | A contraction assay system using primary cultured mouse bronchial smooth muscle cells. | 2013 | Int. Arch. Allergy Immunol. | pmid:23711859 |
| Guan WJ et al. | Impulse oscillometry for leukotriene D4 inhalation challenge in asthma. | 2013 | Respir Care | pmid:23716710 |
| Sharkey LC et al. | Differential cardiotoxicity in response to chronic doxorubicin treatment in male spontaneous hypertension-heart failure (SHHF), spontaneously hypertensive (SHR), and Wistar Kyoto (WKY) rats. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23993975 |
| Kanaoka Y et al. | Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand. | 2013 | J. Biol. Chem. | pmid:23504326 |
| Kang KH et al. | Protection of dopaminergic neurons by 5-lipoxygenase inhibitor. | 2013 | Neuropharmacology | pmid:23800665 |
| Cummings HE et al. | Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor. | 2013 | J. Immunol. | pmid:24244016 |
| Ahmed T et al. | Inhibition of allergic airway responses by heparin derived oligosaccharides: identification of a tetrasaccharide sequence. | 2012 | Respir. Res. | pmid:22269021 |
| Provost V et al. | Leukotriene D4 and interleukin-13 cooperate to increase the release of eotaxin-3 by airway epithelial cells. | 2012 | PLoS ONE | pmid:22952702 |
| Dahlén B et al. | Salbutamol but not ipratropium abolishes leukotriene D4-induced gas exchange abnormalities in asthma. | 2012 | Eur. J. Clin. Pharmacol. | pmid:22457014 |
| Guan W et al. | Leukotriene D4 bronchial provocation test: methodology and diagnostic value. | 2012 | Curr Med Res Opin | pmid:22435894 |
| Forsell PK et al. | Metabolism of anandamide into eoxamides by 15-lipoxygenase-1 and glutathione transferases. | 2012 | Lipids | pmid:22684912 |
| Parmentier CN et al. | Human T(H)2 cells respond to cysteinyl leukotrienes through selective expression of cysteinyl leukotriene receptor 1. | 2012 | J. Allergy Clin. Immunol. | pmid:22391114 |
| Rehn M and Diener M | Cysteinyl leukotrienes mediate the response of submucosal ganglia from rat colon to bradykinin. | 2012 | Eur. J. Pharmacol. | pmid:22366210 |
| Huang XQ et al. | Transforming growth factor β1-induced astrocyte migration is mediated in part by activating 5-lipoxygenase and cysteinyl leukotriene receptor 1. | 2012 | J Neuroinflammation | pmid:22734808 |
| Dannull J et al. | Leukotriene C4 induces migration of human monocyte-derived dendritic cells without loss of immunostimulatory function. | 2012 | Blood | pmid:22323449 |
| Mizutani N et al. | Effect of Ganoderma lucidum on pollen-induced biphasic nasal blockage in a guinea pig model of allergic rhinitis. | 2012 | Phytother Res | pmid:21698671 |
| Pelclová D et al. | Leukotrienes B4, C4, D4 and E4 in the exhaled breath condensate (EBC), blood and urine in patients with pneumoconiosis. | 2012 | Ind Health | pmid:22785421 |
| Matsumoto H et al. | Interleukin-13 enhanced Ca2+ oscillations in airway smooth muscle cells. | 2012 | Cytokine | pmid:22078634 |
| Drost AC et al. | The G protein-coupled receptor CysLT1 mediates chemokine-like effects and prolongs survival in chronic lymphocytic leukemia. | 2012 | Leuk. Lymphoma | pmid:21936770 |
| Huang SC | Leukotriene-induced contraction is mediated by cysteinyl leukotriene receptor CysLT1 in guinea pig fundus but by CysLT1 and CysLT2 in antrum. | 2011 | Life Sci. | pmid:21396378 |
| Brochu-Bourque A et al. | Differential signaling defects associated with the M201V polymorphism in the cysteinyl leukotriene type 2 receptor. | 2011 | J. Pharmacol. Exp. Ther. | pmid:20966037 |
| Zhou Y et al. | Circulating LTD4 in patients with hepatocellular carcinoma. | 2011 | Tumour Biol. | pmid:20820981 |
| Rehni AK and Singh TG | Modulation of leukotriene D4 attenuates the development of seizures in mice. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21641195 |
| Haneda Y et al. | Leukotriene D4 enhances tumor necrosis factor-α-induced vascular endothelial growth factor production in human monocytes/macrophages. | 2011 | Cytokine | pmid:21482134 |
| Daniele S et al. | Agonist-induced desensitization/resensitization of human G protein-coupled receptor 17: a functional cross-talk between purinergic and cysteinyl-leukotriene ligands. | 2011 | J. Pharmacol. Exp. Ther. | pmid:21531793 |
| Cai BL et al. | [Effects of agonist and antagonist of cysteinyl leukotriene receptors on differentiation of rat glioma C6 cells]. | 2011 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:21488208 |
| Itagaki K et al. | Eicosanoid-induced store-operated calcium entry in dendritic cells. | 2011 | J. Surg. Res. | pmid:20080257 |
| Luo H et al. | [Changes of leukotriene D4 in nasal discharge and plasma of patients with persistent allergic rhinitis and the effects of antihistamine]. | 2011 | Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi | pmid:21761705 |
| Ni NC et al. | A selective cysteinyl leukotriene receptor 2 antagonist blocks myocardial ischemia/reperfusion injury and vascular permeability in mice. | 2011 | J. Pharmacol. Exp. Ther. | pmid:21903747 |
| Dartt DA et al. | Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation. | 2011 | J. Immunol. | pmid:21357260 |
| Chen LY et al. | Cooperative and redundant signaling of leukotriene B4 and leukotriene D4 in human monocytes. | 2011 | Allergy | pmid:21605126 |
| Xu L et al. | Involvement of cysteinyl leukotriene receptors in angiogenesis in rat thoracic aortic rings. | 2010 | Pharmazie | pmid:21105577 |
| Lee SJ et al. | 4-Hydroxynonenal enhances MMP-9 production in murine macrophages via 5-lipoxygenase-mediated activation of ERK and p38 MAPK. | 2010 | Toxicol. Appl. Pharmacol. | pmid:19837106 |
| Hayashi S et al. | Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships. | 2010 | Bioorg. Med. Chem. | pmid:20875743 |
| McGovern T et al. | LTDâ‚„ induces HB-EGF-dependent CXCL8 release through EGFR activation in human bronchial epithelial cells. | 2010 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:20889674 |
| Meliton AY et al. | Leukotriene D4 activates {beta}2-integrin adhesion in human polymorphonuclear leukocytes. | 2010 | Eur. Respir. J. | pmid:19679609 |
| Julius P et al. | sCD14 in bronchoalveolar lavage 18, 42 and 162 hours after segmental allergen provocation. | 2010 | Scand. J. Immunol. | pmid:20384875 |
| Wunder F et al. | Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT(2)) receptor. | 2010 | Br. J. Pharmacol. | pmid:20423349 |
| Lieber G et al. | Concomitant activity of histamine and cysteinyl leukotrienes on porcine nasal mucosal vessels and nasal inflammation in the rat. | 2010 | Pharmacology | pmid:20453555 |
| Zhou G et al. | Atorvastatin reduces plaque vulnerability in an atherosclerotic rabbit model by altering the 5-lipoxygenase pathway. | 2010 | Cardiology | pmid:20234134 |
| Kim MH et al. | Effect of leukotriene D4 on mouse embryonic stem cell migration and proliferation: involvement of PI3K/Akt as well as GSK-3β/β-catenin signaling pathways. | 2010 | J. Cell. Biochem. | pmid:20589831 |
| Sakai H et al. | Augmented venous responsiveness to leukotriene D(4) in nasal septal mucosae of repeatedly antigen-challenged rats. | 2010 | Eur. J. Pharmacol. | pmid:20638382 |
| Li R et al. | [Analysis of the nasopharyngeal aspirates in children with different severities of bronchiolitis]. | 2010 | Zhongguo Dang Dai Er Ke Za Zhi | pmid:20497653 |
| Finkensieper A et al. | The 5-lipoxygenase pathway regulates vasculogenesis in differentiating mouse embryonic stem cells. | 2010 | Cardiovasc. Res. | pmid:19965960 |
| Woszczek G et al. | Concentration-dependent noncysteinyl leukotriene type 1 receptor-mediated inhibitory activity of leukotriene receptor antagonists. | 2010 | J. Immunol. | pmid:20083671 |
| Campos MR et al. | Differential kinase requirement for enhancement of Fc gammaR-mediated phagocytosis in alveolar macrophages by leukotriene B4 vs. D4. | 2009 | Mol. Immunol. | pmid:19223078 |
| Lee SP et al. | Crosstalk between prostaglandin E2 and leukotriene B4 regulates phagocytosis in alveolar macrophages via combinatorial effects on cyclic AMP. | 2009 | J. Immunol. | pmid:19109185 |
| Lee TH et al. | Leukotriene E4: perspective on the forgotten mediator. | 2009 | J. Allergy Clin. Immunol. | pmid:19482346 |
| Austen KF et al. | The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications. | 2009 | J. Allergy Clin. Immunol. | pmid:19647860 |
| Theron AJ et al. | Leukotrienes C4 and D4 sensitize human neutrophils for hyperreactivity to chemoattractants. | 2009 | Inflamm. Res. | pmid:19184354 |
| Farias S et al. | Injury-related production of cysteinyl leukotrienes contributes to brain damage following experimental traumatic brain injury. | 2009 | J. Neurotrauma | pmid:19886806 |
| Hashimoto K et al. | Cysteinyl leukotrienes induce monocyte chemoattractant protein-1 in human monocyte/macrophages via mitogen-activated protein kinase and nuclear factor-kappaB pathways. | 2009 | Int. Arch. Allergy Immunol. | pmid:19218821 |
| Muraki M et al. | Inhaled montelukast inhibits cysteinyl-leukotriene-induced bronchoconstriction in ovalbumin-sensitized guinea-pigs: the potential as a new asthma medication. | 2009 | Int. Immunopharmacol. | pmid:19706339 |
| Yuan YM et al. | Leukotriene D4 stimulates the migration but not proliferation of endothelial cells mediated by the cysteinyl leukotriene cyslt(1) receptor via the extracellular signal-regulated kinase pathway. | 2009 | J. Pharmacol. Sci. | pmid:19234368 |
| Broom OJ and Nielsen OH | [The role of cysteinyl leukotrienes in chronic inflammation and neoplasia of the intestine]. | 2009 | Ugeskr. Laeg. | pmid:19174041 |
| Baker N et al. | Lipoxin A4: anti-inflammatory and anti-angiogenic impact on endothelial cells. | 2009 | J. Immunol. | pmid:19265161 |
| Hori M et al. | NT-702 (parogrelil hydrochloride, NM-702), a novel and potent phosphodiesterase 3 inhibitor, suppress the asthmatic response in guinea pigs, with both bronchodilating and anti-inflammatory effects. | 2009 | Eur. J. Pharmacol. | pmid:19616537 |
| Mezhybovska M et al. | Beta-catenin is involved in alterations in mitochondrial activity in non-transformed intestinal epithelial and colon cancer cells. | 2009 | Br. J. Cancer | pmid:19826421 |
| Thivierge M et al. | Cysteinyl-leukotriene receptor type 1 expression and function is down-regulated during monocyte-derived dendritic cell maturation with zymosan: involvement of IL-10 and prostaglandins. | 2009 | J. Immunol. | pmid:19846883 |
| Kim SH et al. | Regulation of monocyte chemoattractant protein 1 by cysteinyl leukotriene D4 in human lung epithelial A549 cells. | 2009 | Ann. Allergy Asthma Immunol. | pmid:19852204 |
| Cai BL et al. | [Method for screening cysteinyl leukotriene receptor 2 antagonists and preliminary screening of compounds]. | 2009 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:20014485 |
| Schäper C et al. | Effects of fexofenadine on inflammatory mediators in nasal lavage fluid in intermittent allergic rhinitis. | 2009 | J Investig Allergol Clin Immunol | pmid:20128420 |
| Selg E et al. | Two different mechanisms for modulation of bronchoconstriction in guinea-pigs by cyclooxygenase metabolites. | 2009 | Prostaglandins Other Lipid Mediat. | pmid:19103301 |