| MeSH term | MeSH ID | Detail |
|---|---|---|
| Airway Obstruction | D000402 | 13 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Inflammatory Bowel Diseases | D015212 | 9 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
LTD4
Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTD4?
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTD4
PubChem Associated disorders and diseases
What pathways are associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTD4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with LTD4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTD4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with LTD4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTD4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTD4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid:25512344 | ||||
| pmid:28410666 | ||||
| pmid:25707327 | ||||
| pmid:25704617 | ||||
| pmid:18651869 | ||||
| pmid:15888248 | ||||
| pmid:28098359 | ||||
| pmid:27881050 | ||||
| pmid:27666014 | ||||
| pmid:26115646 | ||||
| pmid:25103494 | ||||
| pmid:25090924 | ||||
| pmid:24958577 | ||||
| pmid:24735655 | ||||
| pmid:24506412 | ||||
| pmid:9797038 | ||||
| pmid: | ||||
| Tudoric N et al. | Effects of halothane and isoflurane on antigen- and leukotriene-D4-induced constriction of guinea pig trachea. | 1995 | Acta Anaesthesiol Scand | pmid:8607320 |
| Neu IS et al. | Leukotrienes in patients with clinically active multiple sclerosis. | 2002 | Acta Neurol. Scand. | pmid:11903112 |
| Tanaka T et al. | Effect of oxatomide on otitis media with effusion--an experimental study. | 1995 | Acta Otolaryngol. | pmid:7572131 |
| Yu SY et al. | Cysteinyl leukotriene receptor 1 mediates LTD4-induced activation of mouse microglial cells in vitro. | 2014 | Acta Pharmacol. Sin. | pmid:24141567 |
| Jonsson EW | Functional characterisation of receptors for cysteinyl leukotrienes in smooth muscle. | 1998 | Acta Physiol Scand Suppl | pmid:9597121 |
| Kanli H and Terreros DA | Transepithelial transport and cell volume control in proximal renal tubules from the teleost Carassius auratus. | 1997 | Acta Physiol. Scand. | pmid:9246390 |
| Thodeti CK and Sjölander A | Leukotriene D4-induced calcium signaling in human intestinal epithelial cells. | 2002 | Adv. Exp. Med. Biol. | pmid:12664584 |
| Habib GM and Lieberman MW | Cleavage of leukotriene D4 in mice with targeted disruption of a membrane-bound dipeptidase gene. | 1999 | Adv. Exp. Med. Biol. | pmid:10667344 |
| Capra V et al. | Evaluation of the pharmacological activity of the pure cysteinyl-leukotriene receptor antagonists CGP 45715A (iralukast) and CGP 57698 in human airways. | 1999 | Adv. Exp. Med. Biol. | pmid:10667347 |
| Ohd JF et al. | Leukotriene D4-induced signalling events in human epithelial cells: G alpha i3 activation and translocation. | 1997 | Adv. Exp. Med. Biol. | pmid:9561113 |
| von Sprecher A et al. | CGP57698: a structurally simple, highly potent peptido-leukotriene (pLT) antagonist of the quinoline type. | 1997 | Adv. Exp. Med. Biol. | pmid:9561127 |
| Wasserman MA et al. | Synergism exhibited by LTD4 and PAF receptor antagonists in decreasing antigen-induced airway microvascular leakage. | 1995 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7732851 |
| Javed NH et al. | Enhanced tissue responsiveness in colonic ion transport of cow's milk-sensitized guinea pigs. | 1994 | Agents Actions | pmid:7521569 |
| Karaman O et al. | The comparison of the efficacy of fluticasone propionate with cetirizine in perennial allergic rhinitis. | 2001 Mar-Apr | Allergol Immunopathol (Madr) | pmid:11420028 |
| Ishimura M et al. | Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea. | 2006 | Allergol Int | pmid:17130683 |
| Sekioka T et al. | Expression of CysLT2 receptors in asthma lung, and their possible role in bronchoconstriction. | 2015 | Allergol Int | pmid:26433531 |
| Noguchi T et al. | Effect of beta2-adrenergic agonists on eosinophil adhesion, superoxide anion generation, and degranulation. | 2015 | Allergol Int | pmid:26344080 |
| Mills K et al. | Vitamin E, γ-tocopherol, diminishes ex vivo basophil response to dust mite allergen. | 2014 | Allergy | pmid:24697338 |
| Hemelaers L et al. | Cysteinyl-leukotrienes contribute to sputum eosinophil chemotactic activity in asthmatics. | 2006 | Allergy | pmid:16364169 |
| Chen LY et al. | Cooperative and redundant signaling of leukotriene B4 and leukotriene D4 in human monocytes. | 2011 | Allergy | pmid:21605126 |
| Stelmach I et al. | The effect of inhaled heparin on airway responsiveness to histamine and leukotriene D4. | 2003 Jan-Feb | Allergy Asthma Proc | pmid:12635579 |
| Cho JS et al. | The effect of leukotriene D4 on the patency of nasal passage in the guinea pig. | 1998 Nov-Dec | Am J Rhinol | pmid:9883299 |
| Chiba Y et al. | Impaired norepinephrine-mediated contraction of isolated nasal mucosa in guinea pigs with allergic rhinitis. | 2006 Jul-Aug | Am J Rhinol | pmid:16955783 |
| Han B et al. | Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo. | 2002 | Am. J. Pathol. | pmid:12163373 |
| Gronert K et al. | Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses. | 2001 | Am. J. Pathol. | pmid:11141472 |
| Goldhill J et al. | Interleukin-4 modulates cholinergic neural control of mouse small intestinal longitudinal muscle. | 1997 | Am. J. Physiol. | pmid:9176223 |
| Rajah R et al. | Leukotriene D4 induces MMP-1, which functions as an IGFBP protease in human airway smooth muscle cells. | 1996 | Am. J. Physiol. | pmid:8997273 |
| Olszewski MA et al. | Mediators of anaphylaxis but not activated neutrophils augment cholinergic responses of equine small airways. | 1999 | Am. J. Physiol. | pmid:10070118 |
| Pawloski JR and Chapnick BM | Antagonism of LTD4-evoked relaxation in canine renal artery and vein. | 1993 | Am. J. Physiol. | pmid:8214135 |
| Sato E et al. | Acetylcholine stimulates alveolar macrophages to release inflammatory cell chemotactic activity. | 1998 | Am. J. Physiol. | pmid:9609736 |
| Han H et al. | Effects of LTD4 and its specific antagonist L-660,711 in isolated rat hearts with chronic myocardial infarction. | 1994 | Am. J. Physiol. | pmid:8203604 |
| Abela A and Daniel EE | Neural and myogenic effects of leukotrienes C4, D4, and E4 on canine bronchial smooth muscle. | 1994 | Am. J. Physiol. | pmid:8179018 |
| Ganbo T et al. | Leukotriene C4 inhibits ciliary activity in the presence of gamma-glutamyl transpeptidase. | 1996 | Am. J. Physiol. | pmid:8770059 |