LTD4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTD4?

LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTD4

MeSH term MeSH ID Detail
Airway Obstruction D000402 13 associated lipids
Stomach Ulcer D013276 75 associated lipids
Adenocarcinoma D000230 166 associated lipids
Inflammation D007249 119 associated lipids
Inflammatory Bowel Diseases D015212 9 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Gastritis D005756 27 associated lipids
Per page 10 20 50 | Total 39

PubChem Associated disorders and diseases

What pathways are associated with LTD4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTD4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with LTD4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTD4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with LTD4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTD4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTD4

Download all related citations
Per page 10 20 50 100 | Total 640
Authors Title Published Journal PubMed Link
pmid:
Sermasi E et al. Long term depression is expressed during postnatal development in rat visual cortex: a role for visual experience. 1999 Brain Res. Dev. Brain Res. pmid:10064875
Olszewski MA et al. Mediators of anaphylaxis but not activated neutrophils augment cholinergic responses of equine small airways. 1999 Am. J. Physiol. pmid:10070118
White IJ et al. A continuous fluorometric assay for leukotriene D4 hydrolase. 1999 Anal. Biochem. pmid:10075814
Takami M and Tsukada W Effect of DP-1904, a thromboxane synthetase inhibitor, on antigen- and spasmogen-induced bronchoconstriction in rodents. 1999 Eur. J. Pharmacol. pmid:10082207
Pitt CM and Nally JE Angiotensin II-mediated potentiation of endothelin-1-evoked bronchial contractions: a role for leukotrienes? 1999 Pulm Pharmacol Ther pmid:10208831
Mulder A et al. Effect of inhaled leukotriene D4 on airway eosinophilia and airway hyperresponsiveness in asthmatic subjects. 1999 Am. J. Respir. Crit. Care Med. pmid:10228127
Lynch KR et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. 1999 Nature pmid:10391245
Han HJ et al. Leukotriene D4 inhibits Na+ uptake through cAMP and PLC pathways in primary cultured renal proximal tubular cells. 1999 Kidney Blood Press. Res. pmid:10394108
Hoffmann EK Leukotriene D4 (LTD4) activates charybdotoxin-sensitive and -insensitive K+ channels in ehrlich ascites tumor cells. 1999 Pflugers Arch. pmid:10398854
Busse WW et al. Leukotriene pathway inhibitors in asthma and chronic obstructive pulmonary disease. 1999 Clin. Exp. Allergy pmid:10421833
Olszewski MA et al. Pre- and postjunctional effects of inflammatory mediators in horse airways. 1999 Am. J. Physiol. pmid:10444527
Takizawa T et al. Effects of a new antiallergic agent, VUF-K-8788, on experimental asthmatic reactions in guinea pigs. 1999 Pharmacology pmid:10450067
Sarau HM et al. Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. 1999 Mol. Pharmacol. pmid:10462554
Lankisch TO et al. High-affinity cholecystokinin type A receptor/cytosolic phospholipase A2 pathways mediate Ca2+ oscillations via a positive feedback regulation by calmodulin kinase in pancreatic acini. 1999 Eur. J. Cell Biol. pmid:10535305
Yang XX et al. The beta(2)-agonist salbutamol inhibits bronchoconstriction and leukotriene D(4) synthesis after dry gas hyperpnea in the guinea-pig. 1999 Pulm Pharmacol Ther pmid:10545287
Yamashita T and Kokubun S Nonselective cationic currents activated by acetylcholine in swine tracheal smooth muscle cells. 1999 Can. J. Physiol. Pharmacol. pmid:10588484
Mehta KA et al. Effect of formulation and process variables on porosity parameters and release rates from a multi unit erosion matrix of a poorly soluble drug. 2000 J Control Release pmid:10640593
Habib GM and Lieberman MW Cleavage of leukotriene D4 in mice with targeted disruption of a membrane-bound dipeptidase gene. 1999 Adv. Exp. Med. Biol. pmid:10667344
Capra V et al. Evaluation of the pharmacological activity of the pure cysteinyl-leukotriene receptor antagonists CGP 45715A (iralukast) and CGP 57698 in human airways. 1999 Adv. Exp. Med. Biol. pmid:10667347
Mayatepek E et al. Analysis of leukotrienes in cerebrospinal fluid of a reference population and patients with inborn errors of metabolism: further evidence for a pathognomonic profile in LTC(4)-synthesis deficiency. 2000 Clin. Chim. Acta pmid:10686285
Laberge S et al. Antigen-induced airway inflammation and hyper-responsiveness does not enhance airway responses to a subsequent antigen challenge in rats. 2000 Respir Med pmid:10714478
Thodeti CK et al. Leukotriene D(4) triggers an association between gbetagamma subunits and phospholipase C-gamma1 in intestinal epithelial cells. 2000 J. Biol. Chem. pmid:10734140
Underwood DC et al. SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence. 2000 J. Pharmacol. Exp. Ther. pmid:10734180
Hasday JD et al. Anti-inflammatory effects of zileuton in a subpopulation of allergic asthmatics. 2000 Am. J. Respir. Crit. Care Med. pmid:10764316
Ahmed T et al. Inhibition of allergic late airway responses by inhaled heparin-derived oligosaccharides. 2000 J. Appl. Physiol. pmid:10797135
Macfarlane AJ et al. Sputum cysteinyl leukotrienes increase 24 hours after allergen inhalation in atopic asthmatics. 2000 Am. J. Respir. Crit. Care Med. pmid:10806153
Ravasi S et al. A kinetic binding study to evaluate the pharmacological profile of a specific leukotriene C(4) binding site not coupled to contraction in human lung parenchyma. 2000 Mol. Pharmacol. pmid:10825389
Tran HS et al. The cardiovascular hemodynamics and leukotriene kinetics during prostacyclin and anti-prostacyclin antibody infusions in septic shock. 2000 Shock pmid:10847636
Heise CE et al. Characterization of the human cysteinyl leukotriene 2 receptor. 2000 J. Biol. Chem. pmid:10851239
Fukuyama S et al. Effect of eotaxin and platelet-activating factor on airway inflammation and hyperresponsiveness in guinea pigs in vivo. 2000 Am. J. Respir. Crit. Care Med. pmid:10852755
Davis HM et al. Human granulocyte CD11b expression as a pharmacodynamic biomarker of inflammation. 2000 J. Immunol. Methods pmid:10854607
Ballart B et al. Synthesis and pharmacological evaluation of new 4-2-(7-heterocyclemethoxynaftalen-2-ylmethoxy)ethylbenzoic acids as LTD(4)-antagonists. 2000 Eur J Med Chem pmid:10858604
McMahon B et al. Lipoxin A4 antagonizes the mitogenic effects of leukotriene D4 in human renal mesangial cells. Differential activation of MAP kinases through distinct receptors. 2000 J. Biol. Chem. pmid:10869343
Arakida Y et al. In vivo pharmacologic profile of YM158, a new dual antagonist for leukotriene D4 and thromboxane A2 receptors. 2000 Jpn. J. Pharmacol. pmid:10887942
Lopes LR et al. Reduced inflammatory response in rats fed fat-rich diets: role of leukotrienes. 2000 Life Sci. pmid:10896024
Mayatepek E et al. Defects in the synthesis of cysteinyl leukotrienes: a new group of inborn errors of metabolism. 2000 J. Inherit. Metab. Dis. pmid:10896305
Hougaard C et al. K+ currents activated by leukotriene D4 or osmotic swelling in Ehrlich ascites tumour cells. 2000 Pflugers Arch. pmid:10898529
Blain JF and Sirois P Involvement of LTD(4)in allergic pulmonary inflammation in mice: modulation by cysLT(1)antagonist MK-571. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10913229
Turner DJ et al. Bradykinin-induced airway constriction in guinea-pigs: role of leukotriene D(4). 2000 Pulm Pharmacol Ther pmid:10930357
Bäck M et al. Antagonist resistant contractions of the porcine pulmonary artery by cysteinyl-leukotrienes. 2000 Eur. J. Pharmacol. pmid:10936497
Bäck M et al. Prostacyclin modulation of contractions of the human pulmonary artery by cysteinyl-leukotrienes. 2000 Eur. J. Pharmacol. pmid:10936498
Titos E et al. Hepatocyte-derived cysteinyl leukotrienes modulate vascular tone in experimental cirrhosis. 2000 Gastroenterology pmid:10982774
Kodani M et al. Intratracheal administration of anaphylatoxin C5a potentiates antigen-induced pulmonary reactions through the prolonged production of cysteinyl-leukotrienes. 2000 Immunopharmacology pmid:10996024
Ménard G and Bissonnette EY Priming of alveolar macrophages by leukotriene D(4): potentiation of inflammation. 2000 Am. J. Respir. Cell Mol. Biol. pmid:11017925
Ohd JF et al. Leukotrienes induce cell-survival signaling in intestinal epithelial cells. 2000 Gastroenterology pmid:11040187
Thivierge M et al. IL-5 up-regulates cysteinyl leukotriene 1 receptor expression in HL-60 cells differentiated into eosinophils. 2000 J. Immunol. pmid:11046055
Babu KS and Salvi SS Aspirin and asthma. 2000 Chest pmid:11083703
Kalf GF Utility of a mouse model for studying the effects of benzene on the myeloid lineage: effects of hydroquinone on a model myeloid system. 2000 J. Toxicol. Environ. Health Part A pmid:11086946
Nothacker HP et al. Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist. 2000 Mol. Pharmacol. pmid:11093801