| MeSH term | MeSH ID | Detail |
|---|---|---|
| Airway Obstruction | D000402 | 13 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Inflammatory Bowel Diseases | D015212 | 9 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
LTD4
Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTD4?
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTD4
PubChem Associated disorders and diseases
What pathways are associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTD4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTD4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTD4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTD4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTD4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTD4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yu SY et al. | Cysteinyl leukotriene receptor 1 mediates LTD4-induced activation of mouse microglial cells in vitro. | 2014 | Acta Pharmacol. Sin. | pmid:24141567 |
| Jonsson EW | Functional characterisation of receptors for cysteinyl leukotrienes in smooth muscle. | 1998 | Acta Physiol Scand Suppl | pmid:9597121 |
| Kanli H and Terreros DA | Transepithelial transport and cell volume control in proximal renal tubules from the teleost Carassius auratus. | 1997 | Acta Physiol. Scand. | pmid:9246390 |
| Thodeti CK and Sjölander A | Leukotriene D4-induced calcium signaling in human intestinal epithelial cells. | 2002 | Adv. Exp. Med. Biol. | pmid:12664584 |
| Habib GM and Lieberman MW | Cleavage of leukotriene D4 in mice with targeted disruption of a membrane-bound dipeptidase gene. | 1999 | Adv. Exp. Med. Biol. | pmid:10667344 |
| Capra V et al. | Evaluation of the pharmacological activity of the pure cysteinyl-leukotriene receptor antagonists CGP 45715A (iralukast) and CGP 57698 in human airways. | 1999 | Adv. Exp. Med. Biol. | pmid:10667347 |
| Ohd JF et al. | Leukotriene D4-induced signalling events in human epithelial cells: G alpha i3 activation and translocation. | 1997 | Adv. Exp. Med. Biol. | pmid:9561113 |
| von Sprecher A et al. | CGP57698: a structurally simple, highly potent peptido-leukotriene (pLT) antagonist of the quinoline type. | 1997 | Adv. Exp. Med. Biol. | pmid:9561127 |
| Wasserman MA et al. | Synergism exhibited by LTD4 and PAF receptor antagonists in decreasing antigen-induced airway microvascular leakage. | 1995 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7732851 |
| Javed NH et al. | Enhanced tissue responsiveness in colonic ion transport of cow's milk-sensitized guinea pigs. | 1994 | Agents Actions | pmid:7521569 |