LTD4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTD4?

LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTD4

MeSH term MeSH ID Detail
Airway Obstruction D000402 13 associated lipids
Stomach Ulcer D013276 75 associated lipids
Adenocarcinoma D000230 166 associated lipids
Inflammation D007249 119 associated lipids
Inflammatory Bowel Diseases D015212 9 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Gastritis D005756 27 associated lipids
Per page 10 20 50 | Total 39

PubChem Associated disorders and diseases

What pathways are associated with LTD4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTD4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with LTD4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTD4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with LTD4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTD4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTD4

Download all related citations
Per page 10 20 50 100 | Total 640
Authors Title Published Journal PubMed Link
Nielsen CK et al. Leukotriene D4 activates distinct G-proteins in intestinal epithelial cells to regulate stress fibre formation and to generate intracellular Ca2+ mobilisation and ERK1/2 activation. 2005 Exp. Cell Res. pmid:15541723
Ishinaga H et al. Pranlukast inhibits NF-kappaB activation and MUC2 gene expression in cultured human epithelial cells. 2005 Pharmacology pmid:15475658
Gyllfors P et al. Relation between bronchial responsiveness to inhaled leukotriene D4 and markers of leukotriene biosynthesis. 2005 Thorax pmid:16055619
Potter-Perigo S et al. Regulation of proteoglycan synthesis by leukotriene d4 and epidermal growth factor in bronchial smooth muscle cells. 2004 Am. J. Respir. Cell Mol. Biol. pmid:12855404
Mayatepek E et al. Synthesis and metabolism of leukotrienes in gamma-glutamyl transpeptidase deficiency. 2004 J. Lipid Res. pmid:14754911
Sloniewsky DE et al. Leukotriene D4 activates alveolar epithelial Na,K-ATPase and increases alveolar fluid clearance. 2004 Am. J. Respir. Crit. Care Med. pmid:14578215
Asakura T et al. Leukotriene D4 stimulates collagen production from myofibroblasts transformed by TGF-beta. 2004 J. Allergy Clin. Immunol. pmid:15316508
Zhao L et al. The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm. 2004 Nat. Med. pmid:15322539
Wooltorton E Asthma drug zafirlukast (Accolate): serious hepatic events. 2004 CMAJ pmid:15159361
Yang G et al. Transgenic smooth muscle expression of the human CysLT1 receptor induces enhanced responsiveness of murine airways to leukotriene D4. 2004 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:15064240
Wulff T et al. Co-expression of mCysLT1 receptors and IK channels in Xenopus laevis oocytes elicits LTD4-stimulated IK current, independent of an increase in [Ca2+]i. 2004 Biochim. Biophys. Acta pmid:14757222
Tsuji T et al. Differential effects of beta2-adrenoceptor desensitization on the IgE-dependent release of chemical mediators from cultured human mast cells. 2004 Biol. Pharm. Bull. pmid:15467193
Saito K et al. Leukotriene D4 and eosinophil transendothelial migration, superoxide generation, and degranulation via beta2 integrin. 2004 Ann. Allergy Asthma Immunol. pmid:15609771
Nakanishi Y et al. Synergism between cysteinyl leukotrienes and thromboxane A2 to induce allergic late phase nasal blockage in guinea pigs. 2004 Prostaglandins Other Lipid Mediat. pmid:15560121
Capra V et al. CysLT1 signal transduction in differentiated U937 cells involves the activation of the small GTP-binding protein Ras. 2004 Biochem. Pharmacol. pmid:15041474
Ferrari F et al. Pharmacological profile of CR3465, a new leukotriene CysLT1 receptor antagonist with broad anti-inflammatory activity. 2004 Eur. J. Pharmacol. pmid:15541426
Pillai SG et al. A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma. 2004 Pharmacogenetics pmid:15475736
Dupré DJ et al. Inverse agonist activity of selected ligands of the cysteinyl-leukotriene receptor 1. 2004 J. Pharmacol. Exp. Ther. pmid:14718577
Stelmach I et al. The effect of inhaled heparin on airway responsiveness to histamine and leukotriene D4. 2003 Jan-Feb Allergy Asthma Proc pmid:12635579
Murray J et al. Role of leukotrienes in the regulation of human granulocyte behaviour: dissociation between agonist-induced activation and retardation of apoptosis. 2003 Br. J. Pharmacol. pmid:12770944
Sylvin H et al. Cysteinyl leukotrienes in porcine acute allergic airway reactions: bronchial and vascular effects. 2003 Inflamm. Res. pmid:12813622
Klegeris A and McGeer PL Toxicity of human monocytic THP-1 cells and microglia toward SH-SY5Y neuroblastoma cells is reduced by inhibitors of 5-lipoxygenase and its activating protein FLAP. 2003 J. Leukoc. Biol. pmid:12629151
Sugahara S et al. Kinins are involved in the development of allergic nasal hyperresponsiveness in guinea pigs. 2003 Eur. J. Pharmacol. pmid:12969770
Sundström E et al. Interactions among three classes of mediators explain antigen-induced bronchoconstriction in the isolated perfused and ventilated guinea pig lung. 2003 J. Pharmacol. Exp. Ther. pmid:12954791
Espinosa K et al. CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4. 2003 J. Allergy Clin. Immunol. pmid:12743568
Vargaftig BB and Singer M Leukotrienes mediate part of Ova-induced lung effects in mice via EGFR. 2003 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:12794006
Crimi N et al. Inhibitory effect of a leukotriene receptor antagonist (montelukast) on neurokinin A-induced bronchoconstriction. 2003 J. Allergy Clin. Immunol. pmid:12704366
Mazzetti L et al. The ACh-induced contraction in rat aortas is mediated by the Cys Lt1 receptor via intracellular calcium mobilization in smooth muscle cells. 2003 Br. J. Pharmacol. pmid:12598425
Peters SP Leukotriene receptor antagonists in asthma therapy. 2003 J. Allergy Clin. Immunol. pmid:12532087
Vargaftig BB and Singer M Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13. 2003 Am. J. Respir. Cell Mol. Biol. pmid:12654629
Smyth TP et al. A substrate variant as a high-affinity, reversible inhibitor: insight from the X-ray structure of cilastatin bound to membrane dipeptidase. 2003 Bioorg. Med. Chem. pmid:12614884
Wikström K et al. The anti-apoptotic effect of leukotriene D4 involves the prevention of caspase 8 activation and Bid cleavage. 2003 Biochem. J. pmid:12482325
Kawano T et al. Cysteinyl leukotrienes induce nuclear factor kappa b activation and RANTES production in a murine model of asthma. 2003 J. Allergy Clin. Immunol. pmid:12897744
Paruchuri S and Sjölander A Leukotriene D4 mediates survival and proliferation via separate but parallel pathways in the human intestinal epithelial cell line Int 407. 2003 J. Biol. Chem. pmid:12912998
Suzuki M et al. Inhibition of human eosinophil activation by a cysteinyl leukotriene receptor antagonist (pranlukast; ONO-1078). 2003 J Asthma pmid:12870835
Massoumi R et al. Leukotriene D4-induced adhesion of Caco-2 cells is mediated by prostaglandin E2 and upregulation of alpha2beta1-integrin. 2003 Exp. Cell Res. pmid:14499635
Thompson MD et al. A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha. 2003 Pharmacogenetics pmid:14515063
Capra V et al. Involvement of prenylated proteins in calcium signaling induced by LTD4 in differentiated U937 cells. 2003 Prostaglandins Other Lipid Mediat. pmid:14518564
Schuhmann MU et al. Temporal profiles of cerebrospinal fluid leukotrienes, brain edema and inflammatory response following experimental brain injury. 2003 Neurol. Res. pmid:12866196
Soberman RJ and Christmas P The organization and consequences of eicosanoid signaling. 2003 J. Clin. Invest. pmid:12697726
Chibana K et al. Up-regulation of cysteinyl leukotriene 1 receptor by IL-13 enables human lung fibroblasts to respond to leukotriene C4 and produce eotaxin. 2003 J. Immunol. pmid:12682264
Liu P et al. Cysteinyl leukotriene-dependent [Ca2+]i responses to angiotensin II in cardiomyocytes. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12531730
Hattori T et al. Effects of H2O2 on membrane potential of smooth muscle cells in rabbit mesenteric resistance artery. 2003 Eur. J. Pharmacol. pmid:12620501
Ichiyama T et al. Pranlukast inhibits NF-kappa B activation in human monocytes/macrophages and T cells. 2003 Clin. Exp. Allergy pmid:12801316
Mizutani N [Studies on the experimental allergic rhinitis induced by Japanese cedar pollen--role of cysteinyl leukotrienes in nasal allergic symptoms]. 2003 Yakugaku Zasshi pmid:12607939
Bouchelouche K et al. The cysteinyl-leukotriene D4 induces cytosolic Ca2+ elevation and contraction of the human detrusor muscle. 2003 J. Urol. pmid:12853847
Mechiche H et al. Effects of cysteinyl leukotrienes in small human bronchus and antagonist activity of montelukast and its metabolites. 2003 Clin. Exp. Allergy pmid:12859443
Nagase T et al. A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice. 2003 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:12505870
Kurogi Y Mesangial cell proliferation inhibitors for the treatment of proliferative glomerular disease. 2003 Med Res Rev pmid:12424751
Marusova IB et al. [Potential gastroprotective effect of a CysLT1 receptor blocker sodium montelukast in aspirin-induced lesions of the rat stomach mucosa]. 2002 May-Jun Eksp Klin Farmakol pmid:12227087
McMahon B et al. Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation. 2002 FASEB J. pmid:12223454
Thodeti CK and Sjölander A Leukotriene D4-induced calcium signaling in human intestinal epithelial cells. 2002 Adv. Exp. Med. Biol. pmid:12664584
Suzuki R and Freed AN Heparin inhibits hyperventilation-induced late-phase hyperreactivity in dogs. 2002 Am. J. Respir. Crit. Care Med. pmid:11779726
Ohshima N et al. A functional study on CysLT(1) receptors in human eosinophils. 2002 Int. Arch. Allergy Immunol. pmid:12373000
Ravasi S et al. Pharmacological differences among CysLT(1) receptor antagonists with respect to LTC(4) and LTD(4) in human lung parenchyma. 2002 Biochem. Pharmacol. pmid:11996896
Maekawa A et al. Targeted gene disruption reveals the role of cysteinyl leukotriene 1 receptor in the enhanced vascular permeability of mice undergoing acute inflammatory responses. 2002 J. Biol. Chem. pmid:11932261
Tada N et al. Experimental otitis media with effusion induced by leukotriene D4. 2002 Auris Nasus Larynx pmid:11893446
Li X and Weinman SA Mrp2 modulates the activity of chloride channels in isolated hepatocytes. 2002 Hepatology pmid:12085350
Bandeira-Melo C et al. Intracrine cysteinyl leukotriene receptor-mediated signaling of eosinophil vesicular transport-mediated interleukin-4 secretion. 2002 J. Exp. Med. pmid:12235216
Shahbazian A et al. Differential peristaltic motor effects of prostanoid (DP, EP, IP, TP) and leukotriene receptor agonists in the guinea-pig isolated small intestine. 2002 Br. J. Pharmacol. pmid:12429577
Walch L et al. Pharmacological evidence for a novel cysteinyl-leukotriene receptor subtype in human pulmonary artery smooth muscle. 2002 Br. J. Pharmacol. pmid:12466244
Neu IS et al. Leukotrienes in patients with clinically active multiple sclerosis. 2002 Acta Neurol. Scand. pmid:11903112
Sakata K and Bäck M Receptor preferences of cysteinyl-leukotrienes in the guinea pig lung parenchyma. 2002 Eur. J. Pharmacol. pmid:11834255
Obase Y et al. Effects of pranlukast on chemical mediators in induced sputum on provocation tests in atopic and aspirin-intolerant asthmatic patients. 2002 Chest pmid:11796443
Braccioni F et al. The effect of cysteinyl leukotrienes on growth of eosinophil progenitors from peripheral blood and bone marrow of atopic subjects. 2002 J. Allergy Clin. Immunol. pmid:12110827
Bandeira-Melo C et al. Cysteinyl leukotrienes induce IL-4 release from cord blood-derived human eosinophils. 2002 J. Allergy Clin. Immunol. pmid:12063527
Uemura M et al. Cysteinyl leukotrienes in the bile of patients with obstructive jaundice. 2002 J. Gastroenterol. pmid:12424566
Tokuyama K et al. Effects of Y-27632, a Rho/Rho kinase inhibitor, on leukotriene D(4)- and histamine-induced airflow obstruction and airway microvascular leakage in guinea pigs in vivo. 2002 Pharmacology pmid:11893899
Lee KH et al. Increased expression of endothelial cell adhesion molecules due to mediator release from human foreskin mast cells stimulated by autoantibodies in chronic urticaria sera. 2002 J. Invest. Dermatol. pmid:11918713
Li PC et al. Enhanced activity of Ca2+-activated K+ channels by 1-[2-hydroxy-3-propyl-4-[(1H-tetrazol-5-yl)butoxyl]phenyl] ethanone (LY-171883) in neuroendocrine and neuroblastoma cell lines. 2002 J. Cell. Physiol. pmid:12115725
Massoumi R et al. Leukotriene D(4) induces stress-fibre formation in intestinal epithelial cells via activation of RhoA and PKCdelta. 2002 J. Cell. Sci. pmid:12154081
Han B et al. Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo. 2002 Am. J. Pathol. pmid:12163373
Paruchuri S et al. Leukotriene D(4) activates MAPK through a Ras-independent but PKCepsilon-dependent pathway in intestinal epithelial cells. 2002 J. Cell. Sci. pmid:11956320
Stelmach I et al. [The effect of inhaled heparin on post-leukotriene bronchoconstriction in children with bronchial asthma]. 2002 Pol. Merkur. Lekarski pmid:11995261
Allakhverdi Z et al. Inhibition of antigen-induced eosinophilia and airway hyperresponsiveness by antisense oligonucleotides directed against the common beta chain of IL-3, IL-5, GM-CSF receptors in a rat model of allergic asthma. 2002 Am. J. Respir. Crit. Care Med. pmid:11934731
Lavoie JP et al. Comparison of effects of dexamethasone and the leukotriene D4 receptor antagonist L-708,738 on lung function and airway cytologic findings in horses with recurrent airway obstruction. 2002 Am. J. Vet. Res. pmid:11939323
Nagata M et al. Leukotriene D4 upregulates eosinophil adhesion via the cysteinyl leukotriene 1 receptor. 2002 J. Allergy Clin. Immunol. pmid:11941318
Evans JF Cysteinyl leukotriene receptors. 2002 Prostaglandins Other Lipid Mediat. pmid:12432945
Ketchell RI et al. Contrasting effects of allergen challenge on airway responsiveness to cysteinyl leukotriene D(4) and methacholine in mild asthma. 2002 Thorax pmid:12096198
Shirasaki H et al. Expression and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa. 2002 Clin. Exp. Allergy pmid:12100046
Thodeti CK et al. Leukotriene D4 induces association of active RhoA with phospholipase C-gamma1 in intestinal epithelial cells. 2002 Biochem. J. pmid:12071848
Bäck M Functional characteristics of cysteinyl-leukotriene receptor subtypes. 2002 Life Sci. pmid:12072150
Terada T et al. Effect of oral antigen administration on nasal blockage in experimental allergic rhinitis in guinea pigs. 2002 Inflamm. Res. pmid:12058959
Nag S et al. Interleukin-2-induced increased airway responsiveness and lung Th2 cytokine expression occur after antigen challenge through the leukotriene pathway. 2002 Am. J. Respir. Crit. Care Med. pmid:12045130
Sheller J et al. The prostaglandin E agonist, misoprostol, inhibits airway IL-5 production in atopic asthmatics. 2002 Prostaglandins Other Lipid Mediat. pmid:12428688
Karaman O et al. The comparison of the efficacy of fluticasone propionate with cetirizine in perennial allergic rhinitis. 2001 Mar-Apr Allergol Immunopathol (Madr) pmid:11420028
Aoki M et al. Antiasthmatic effect of YM976, a novel PDE4 inhibitor, in guinea pigs. 2001 J. Pharmacol. Exp. Ther. pmid:11259541
Campos MG et al. Galphimia glauca organic fraction antagonizes LTD(4)-induced contraction in guinea pig airways. 2001 J Ethnopharmacol pmid:11137344
Thodeti CK et al. The epsilon isoform of protein kinase C is involved in regulation of the LTD(4)-induced calcium signal in human intestinal epithelial cells. 2001 Exp. Cell Res. pmid:11139333
Venugopal CS et al. Comparative responses of bronchial rings to mediators of airway hyperreactivity in healthy horses and those affected with summer pasture-associated obstructive pulmonary disease. 2001 Am. J. Vet. Res. pmid:11212036
Massoumi R and Sjölander A Leukotriene D(4) affects localisation of vinculin in intestinal epithelial cells via distinct tyrosine kinase and protein kinase C controlled events. 2001 J. Cell. Sci. pmid:11329379
Maekawa A et al. Identification in mice of two isoforms of the cysteinyl leukotriene 1 receptor that result from alternative splicing. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11226226
Saegusa S et al. Leukotriene D(4)-induced Rho-mediated actin reorganization in human bronchial smooth muscle cells. 2001 Eur. J. Pharmacol. pmid:11226389
Bautz F et al. Chemotaxis and transendothelial migration of CD34(+) hematopoietic progenitor cells induced by the inflammatory mediator leukotriene D4 are mediated by the 7-transmembrane receptor CysLT1. 2001 Blood pmid:11369634
Bouchelouche K et al. Calcium signaling in cultured human detrusor smooth muscle cells from patients with interstitial cystitis. 2001 Urology pmid:11378073
Bouchelouche K et al. Cysteinyl-leukotriene D(4) receptors in smooth muscle cells. 2001 Urology pmid:11378074
Nabe T et al. Comparison of cedar pollen-induced allergic rhinitis in passively and actively sensitized guinea pigs. 2001 Jpn. J. Pharmacol. pmid:11388645
Ruck LM et al. Synergistic antiallergic activity of combined histamine H1- and cysteinyl leukotriene1-receptor blockade in human bronchus. 2001 Life Sci. pmid:11432448
Simons FE et al. Suppression of the early and late cutaneous allergic responses using fexofenadine and montelukast. 2001 Ann. Allergy Asthma Immunol. pmid:11206237
Accomazzo MR et al. Leukotriene D4-induced activation of smooth-muscle cells from human bronchi is partly Ca2+-independent. 2001 Am. J. Respir. Crit. Care Med. pmid:11208655