LTD4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTD4?

LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTD4

MeSH term MeSH ID Detail
Airway Obstruction D000402 13 associated lipids
Stomach Ulcer D013276 75 associated lipids
Adenocarcinoma D000230 166 associated lipids
Inflammation D007249 119 associated lipids
Inflammatory Bowel Diseases D015212 9 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Gastritis D005756 27 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTD4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTD4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTD4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTD4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTD4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTD4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTD4

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Per page 10 20 50 100 | Total 640
Authors Title Published Journal PubMed Link
Georgitis JW et al. Chronic sinusitis: characterization of cellular influx and inflammatory mediators in sinus lavage fluid. 1995 Int. Arch. Allergy Immunol. pmid:7719157
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Conroy DM et al. Relaxant effects of pituitary adenylate cyclase activating polypeptide (PACAP) on epithelium-intact and -denuded guinea-pig trachea: a comparison with vasoactive intestinal peptide (VIP). 1995 Neuropeptides pmid:8538872
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Hazel BA et al. Benzene and its metabolite, hydroquinone, induce granulocytic differentiation in myeloblasts by interacting with cellular signaling pathways activated by granulocyte colony-stimulating factor. 1995 Stem Cells pmid:7542115
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Ganbo T et al. The effects of leukotrienes C4 and D4 on ciliary activity of human paranasal sinus mucosa in vitro. 1995 Rhinology pmid:8919211
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Bonnefoi MS et al. Subchronic toxicity studies with the leukotriene D4 antagonist RG 12525. 1995 Fundam Appl Toxicol pmid:8566477
Wood-Baker R et al. The reproducibility and effect on non-specific airway responsiveness of inhaled prostaglandin D2 and leukotriene D4 in asthmatic subjects. 1995 Br J Clin Pharmacol pmid:7742148
Rajah R et al. Insulin-like growth factor binding protein (IGFBP) proteases: functional regulators of cell growth. 1995 Prog. Growth Factor Res. pmid:8817670
Madsen F et al. Challenge interval determines tachyphylaxis to aerosolized LTD4. 1995 Pulm Pharmacol pmid:8819178
Tanaka H et al. The effect of a novel leukotriene C4/D4 antagonist, BAY-x-7195, on experimental allergic reactions. 1995 Nov-Dec Prostaglandins pmid:8838238
Bäck M et al. The cysteinyl-leukotriene receptor antagonist BAY u9773 is a competitive antagonist of leukotriene C4 in the guinea-pig ileum. 1996 Eur. J. Pharmacol. pmid:8982726
Burghardt JS et al. Lipid mediators in oxygen-induced airway remodeling and hyperresponsiveness in newborn rats. 1996 Am. J. Respir. Crit. Care Med. pmid:8887572
Fukai F et al. Transcellular biosynthesis of cysteinyl leukotrienes by Kupffer cell-hepatocyte cooperation in rat liver. 1996 Cell Biol. Int. pmid:8858827
Martin CA et al. In vitro pharmacological effects of S 12370 (2-[4-benzhydryloxypiperidinoethyl]isoxindole; an antibronchoconstrictor agent) in normal and sensitized tissue. 1996 Fundam Clin Pharmacol pmid:8902549
Garcia C et al. Effects of synthetic peptido-leukotrienes on bone resorption in vitro. 1996 J. Bone Miner. Res. pmid:8992883
Hazel BA et al. Induction of granulocytic differentiation in a mouse model by benzene and hydroquinone. 1996 Environ. Health Perspect. pmid:9118902
Tominaga M et al. ONO-1078 antagonizes diarrhea-causing changes in ion transport and smooth muscle contraction induced by peptidoleukotrienes in rat and human colon in vitro. 1996 J. Pharmacol. Exp. Ther. pmid:8819486
Joki S et al. Effect of leukotriene D4 on ciliary activity in human, guinea-pig and rat respiratory mucosa. 1996 Pulm Pharmacol pmid:9160411
Papayianni A et al. Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells. 1996 J. Immunol. pmid:8690917
Kang BC et al. Experimental asthma developed by room air contamination with cockroach allergen. 1996 Int. Arch. Allergy Immunol. pmid:8917126
Ganbo T et al. Leukotriene C4 inhibits ciliary activity in the presence of gamma-glutamyl transpeptidase. 1996 Am. J. Physiol. pmid:8770059
Funayama T et al. Role of Leukotriene-degrading enzymes in pulmonary response to antigen infusion in sensitized guinea pigs in vivo. 1996 Am. J. Respir. Cell Mol. Biol. pmid:8703483
Grönroos E et al. Leukotriene D4-induced mobilization of intracellular Ca2+ in epithelial cells is critically dependent on activation of the small GTP-binding protein Rho. 1996 Biochem. J. pmid:8645211