LTD4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTD4?

LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTD4

MeSH term MeSH ID Detail
Airway Obstruction D000402 13 associated lipids
Stomach Ulcer D013276 75 associated lipids
Adenocarcinoma D000230 166 associated lipids
Inflammation D007249 119 associated lipids
Inflammatory Bowel Diseases D015212 9 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Gastritis D005756 27 associated lipids
Per page 10 20 50 | Total 39

PubChem Associated disorders and diseases

What pathways are associated with LTD4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTD4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTD4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTD4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTD4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTD4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTD4

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Per page 10 20 50 100 | Total 640
Authors Title Published Journal PubMed Link
Venugopal CS et al. Comparative responses of bronchial rings to mediators of airway hyperreactivity in healthy horses and those affected with summer pasture-associated obstructive pulmonary disease. 2001 Am. J. Vet. Res. pmid:11212036
Tohda Y et al. Role of chemical mediators in airway hyperresponsiveness in an asthmatic model. 2001 Respiration pmid:11223734
Maekawa A et al. Identification in mice of two isoforms of the cysteinyl leukotriene 1 receptor that result from alternative splicing. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11226226
Saegusa S et al. Leukotriene D(4)-induced Rho-mediated actin reorganization in human bronchial smooth muscle cells. 2001 Eur. J. Pharmacol. pmid:11226389
Aoki M et al. Antiasthmatic effect of YM976, a novel PDE4 inhibitor, in guinea pigs. 2001 J. Pharmacol. Exp. Ther. pmid:11259541
Massoumi R and Sjölander A Leukotriene D(4) affects localisation of vinculin in intestinal epithelial cells via distinct tyrosine kinase and protein kinase C controlled events. 2001 J. Cell. Sci. pmid:11329379
Bouchelouche K et al. The action of cysteinyl-leukotrienes on intracellular calcium mobilization in human detrusor myocytes. 2001 BJU Int. pmid:11350414
Oliveira SH et al. SCF-induced airway hyperreactivity is dependent on leukotriene production. 2001 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:11350804
Snetkov VA et al. Mechanisms of leukotriene D4-induced constriction in human small bronchioles. 2001 Br. J. Pharmacol. pmid:11350860
Bautz F et al. Chemotaxis and transendothelial migration of CD34(+) hematopoietic progenitor cells induced by the inflammatory mediator leukotriene D4 are mediated by the 7-transmembrane receptor CysLT1. 2001 Blood pmid:11369634
Bouchelouche K et al. Calcium signaling in cultured human detrusor smooth muscle cells from patients with interstitial cystitis. 2001 Urology pmid:11378073
Bouchelouche K et al. Cysteinyl-leukotriene D(4) receptors in smooth muscle cells. 2001 Urology pmid:11378074
Nabe T et al. Comparison of cedar pollen-induced allergic rhinitis in passively and actively sensitized guinea pigs. 2001 Jpn. J. Pharmacol. pmid:11388645
Karaman O et al. The comparison of the efficacy of fluticasone propionate with cetirizine in perennial allergic rhinitis. 2001 Mar-Apr Allergol Immunopathol (Madr) pmid:11420028
Ruck LM et al. Synergistic antiallergic activity of combined histamine H1- and cysteinyl leukotriene1-receptor blockade in human bronchus. 2001 Life Sci. pmid:11432448
Möhle R et al. Transendothelial migration of hematopoietic progenitor cells. Role of chemotactic factors. 2001 Ann. N. Y. Acad. Sci. pmid:11458515
Mizutani N et al. Markedly increased nasal blockage by intranasal leukotriene D4 in an experimental allergic rhinitis model: contribution of dilated mucosal blood vessels. 2001 Jpn. J. Pharmacol. pmid:11459119
Echazarreta AL et al. Pulmonary gas exchange and sputum cellular responses to inhaled leukotriene D(4) in asthma. 2001 Am. J. Respir. Crit. Care Med. pmid:11463588
Shi ZZ et al. Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D(4) synthesis in vivo and attenuation of the acute inflammatory response. 2001 Mol. Cell. Biol. pmid:11463821
Bäck M et al. An alternative pathway for metabolism of leukotriene D(4): effects on contractions to cysteinyl-leukotrienes in the guinea-pig trachea. 2001 Br. J. Pharmacol. pmid:11487525