LTD4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTD4?

LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTD4

MeSH term MeSH ID Detail
Airway Obstruction D000402 13 associated lipids
Stomach Ulcer D013276 75 associated lipids
Adenocarcinoma D000230 166 associated lipids
Inflammation D007249 119 associated lipids
Inflammatory Bowel Diseases D015212 9 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Gastritis D005756 27 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTD4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTD4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTD4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTD4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTD4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTD4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTD4

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Authors Title Published Journal PubMed Link
Nishida T et al. Effects of leukotriene D4 on myocardial blood flow and high energy phosphate concentration in anesthetized dogs. 1994 Jpn. Circ. J. pmid:7967000
Hoheisel U and Mense S Leukotriene D4 depresses the mechanosensitivity of group III and IV muscle receptors in the rat. 1994 Neuroreport pmid:8025261
Hirata F et al. IL-1 beta regulates the expression of the Gi2 alpha gene via lipid mediators in guinea pig tracheal muscle. 1994 Biochem. Biophys. Res. Commun. pmid:7945342
Ichinose M et al. Antigen-induced airway responses are inhibited by a potassium channel opener. 1994 Am. J. Respir. Crit. Care Med. pmid:7519521
Javed NH et al. Enhanced tissue responsiveness in colonic ion transport of cow's milk-sensitized guinea pigs. 1994 Agents Actions pmid:7521569
Undem BJ et al. Recombinant stem cell factor-induced mast cell activation and smooth muscle contraction in human bronchi. 1994 Am. J. Respir. Cell Mol. Biol. pmid:7524570
Nabe T et al. Inhibitory effect of ONO-1078 on specific binding of peptide leukotrienes to human lung crude membrane. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:7824530
Petric R and Ford-Hutchinson AW Elevated cysteinyl leukotriene excretion in experimental glomerulonephritis. 1994 Kidney Int. pmid:7853790
An S et al. Molecular cloning of sheep lung dipeptidase: a glycosyl phosphatidylinositol-anchored ectoenzyme that converts leukotriene D4 to leukotriene E4. 1994 Biochim. Biophys. Acta pmid:8054366
Tsopanoglou NE et al. Leukotrienes C4 and D4 promote angiogenesis via a receptor-mediated interaction. 1994 Eur. J. Pharmacol. pmid:7523148
Callaghan DH et al. Respiratory tract eicosanoid measurement using microdialysis sampling and GC/MS detection. 1994 Pulm Pharmacol pmid:8003850
Dandurand RJ et al. In vitro allergic bronchoconstriction in the brown Norway rat. 1994 Am. J. Respir. Crit. Care Med. pmid:8004305
Underwood DC et al. Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs. 1994 J. Pharmacol. Exp. Ther. pmid:8035322
Metters KM et al. Characterization of specific binding sites for cysteinyl leukotrienes in sheep lung. 1994 J. Pharmacol. Exp. Ther. pmid:8035338
Diener M and Scharrer E The effect of short-chain fatty acids on Cl- and K+ conductance in rat colonic crypts. 1994 Pflugers Arch. pmid:8052516
Chan CC et al. Evaluation of bronchoconstriction induced by neurokinins and its inhibition by selective nonpeptide antagonists in conscious guinea pigs, using a double-chamber plethysmograph technique. 1994 Can. J. Physiol. Pharmacol. pmid:8012892
Kurosawa M et al. Inhibition by a novel peptide leukotriene receptor antagonist ONO-1078 of airway wall thickening and airway hyperresponsiveness to histamine induced by leukotriene C4 or leukotriene D4 in guinea-pigs. 1994 Clin. Exp. Allergy pmid:7842366
Herd CM et al. Effect of a 5-lipoxygenase inhibitor and leukotriene antagonist (PF 5901) on antigen-induced airway responses in neonatally immunized rabbits. 1994 Br. J. Pharmacol. pmid:8032653
Thioudellet C et al. Molecular and functional characterization of recombinant human gamma-glutamyltransferase. Coupling of its activity to glutathione levels in V79 cells. 1994 Eur. J. Biochem. pmid:7913033
Kano M Calcium-induced long-lasting potentiation of GABAergic currents in cerebellar Purkinje cells. 1994 Jpn. J. Physiol. pmid:7752516