| MeSH term | MeSH ID | Detail |
|---|---|---|
| Airway Obstruction | D000402 | 13 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Inflammatory Bowel Diseases | D015212 | 9 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
LTD4
Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTD4?
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTD4
PubChem Associated disorders and diseases
What pathways are associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTD4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTD4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTD4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTD4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTD4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTD4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Jiang Y et al. | CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells. | 2007 | Blood | pmid:17693579 |
| Peres CM et al. | Specific leukotriene receptors couple to distinct G proteins to effect stimulation of alveolar macrophage host defense functions. | 2007 | J. Immunol. | pmid:17911632 |
| Chiba Y et al. | Impaired norepinephrine-mediated contraction of isolated nasal mucosa in guinea pigs with allergic rhinitis. | 2006 Jul-Aug | Am J Rhinol | pmid:16955783 |
| Ishimura M et al. | Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea. | 2006 | Allergol Int | pmid:17130683 |
| Thivierge M et al. | Toll-like receptor agonists differentially regulate cysteinyl-leukotriene receptor 1 expression and function in human dendritic cells. | 2006 | J. Allergy Clin. Immunol. | pmid:16675346 |
| Abe M et al. | A novel method for preserving human lungs using a super-cooling system. | 2006 | Ann. Thorac. Surg. | pmid:16928543 |
| Hoopes C | Invited commentary. | 2006 | Ann. Thorac. Surg. | pmid:16928544 |
| Dahlén SE | Treatment of asthma with antileukotrienes: first line or last resort therapy? | 2006 | Eur. J. Pharmacol. | pmid:16510137 |
| Gyllfors P et al. | Bronchial responsiveness to leukotriene D4 is resistant to inhaled fluticasone propionate. | 2006 | J. Allergy Clin. Immunol. | pmid:16815141 |
| Hemelaers L et al. | Cysteinyl-leukotrienes contribute to sputum eosinophil chemotactic activity in asthmatics. | 2006 | Allergy | pmid:16364169 |
| Mezhybovska M et al. | The inflammatory mediator leukotriene D4 induces beta-catenin signaling and its association with antiapoptotic Bcl-2 in intestinal epithelial cells. | 2006 | J. Biol. Chem. | pmid:16407243 |
| Nieves D and Moreno JJ | Role of 5-lipoxygenase pathway in the regulation of RAW 264.7 macrophage proliferation. | 2006 | Biochem. Pharmacol. | pmid:16934759 |
| Carvajal MT and Staniforth JN | Interactions of water with the surfaces of crystal polymorphs. | 2006 | Int J Pharm | pmid:16298501 |
| Cui S et al. | Effects of platelet-activating factor, thromboxane A2 and leukotriene D4 on isolated perfused rat liver. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16846785 |
| Tanaka Y et al. | Different mechanisms between thromboxane A2- and leukotriene D4-induced nasal blockage in guinea pigs. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16939879 |
| Chiba Y et al. | Effects of 1400W, a potent selective inducible NOS inhibitor, on histamine- and leukotriene D4-induced relaxation of isolated guinea pig nasal mucosa. | 2006 | Nitric Oxide | pmid:16442819 |
| Lefebvre B et al. | Effect of 5-lipoxygenase blockade on blood pressure and acetylcholine-evoked endothelium-dependent contraction in aorta from spontaneously hypertensive rats. | 2006 | J. Hypertens. | pmid:16331105 |
| Rovati GE et al. | Cysteinyl-leukotrienes in the regulation of beta2-adrenoceptor function: an in vitro model of asthma. | 2006 | Respir. Res. | pmid:16875498 |
| Lamoureux J et al. | Leukotriene D4 enhances immunoglobulin production in CD40-activated human B lymphocytes. | 2006 | J. Allergy Clin. Immunol. | pmid:16630953 |
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| Ravasi S et al. | CysLT1 receptor-induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1/2 phosphorylation. | 2006 | Respir. Res. | pmid:16553950 |
| Bouchelouche K and Bouchelouche P | Cysteinyl leukotriene D4 increases human detrusor muscle responsiveness to histamine. | 2006 | J. Urol. | pmid:16753444 |
| Thompson C et al. | CysLT1 receptor engagement induces activator protein-1- and NF-kappaB-dependent IL-8 expression. | 2006 | Am. J. Respir. Cell Mol. Biol. | pmid:16809637 |
| Paruchuri S et al. | Endogenous production of leukotriene D4 mediates autocrine survival and proliferation via CysLT1 receptor signalling in intestinal epithelial cells. | 2006 | Oncogene | pmid:16715140 |
| Wang ML et al. | Leukotriene D4 induces brain edema and enhances CysLT2 receptor-mediated aquaporin 4 expression. | 2006 | Biochem. Biophys. Res. Commun. | pmid:17010308 |
| Shimoda H et al. | Anti type I allergic property of Japanese butterbur extract and its mast cell degranulation inhibitory ingredients. | 2006 | J. Agric. Food Chem. | pmid:16608208 |
| Mayatepek E et al. | A patient with neurological symptoms and abnormal leukotriene metabolism: a new defect in leukotriene biosynthesis. | 2005 | Ann. Neurol. | pmid:16315285 |
| Neves JS et al. | Evaluating the prophylactic potential of the phtalimide derivative LASSBio 552 on allergen-evoked inflammation in rats. | 2005 | Eur. J. Pharmacol. | pmid:15792791 |
| Naik S et al. | Regulation of cysteinyl leukotriene type 1 receptor internalization and signaling. | 2005 | J. Biol. Chem. | pmid:15590629 |
| Capra V et al. | CysLT1 receptor is a target for extracellular nucleotide-induced heterologous desensitization: a possible feedback mechanism in inflammation. | 2005 | J. Cell. Sci. | pmid:16306225 |
| Matsuse H et al. | Naturally occurring parainfluenza virus 3 infection in adults induces mild exacerbation of asthma associated with increased sputum concentrations of cysteinyl leukotrienes. | 2005 | Int. Arch. Allergy Immunol. | pmid:16215328 |
| Nielsen CK et al. | Leukotriene D4 activates distinct G-proteins in intestinal epithelial cells to regulate stress fibre formation and to generate intracellular Ca2+ mobilisation and ERK1/2 activation. | 2005 | Exp. Cell Res. | pmid:15541723 |
| Ishinaga H et al. | Pranlukast inhibits NF-kappaB activation and MUC2 gene expression in cultured human epithelial cells. | 2005 | Pharmacology | pmid:15475658 |
| Mezhybovska M et al. | Pro-inflammatory mediator leukotriene D4 induces transcriptional activity of potentially oncogenic genes. | 2005 | Biochem. Soc. Trans. | pmid:16042577 |
| Kato J et al. | Leukotriene D4 potentiates fibronectin-induced migration of human lung fibroblasts. | 2005 | Clin. Immunol. | pmid:16109507 |
| Prinz I et al. | The type 1 cysteinyl leukotriene receptor triggers calcium influx and chemotaxis in mouse alpha beta- and gamma delta effector T cells. | 2005 | J. Immunol. | pmid:16002666 |
| Paruchuri S et al. | The pro-inflammatory mediator leukotriene D4 induces phosphatidylinositol 3-kinase and Rac-dependent migration of intestinal epithelial cells. | 2005 | J. Biol. Chem. | pmid:15657050 |
| Nielsen CK et al. | A novel localization of the G-protein-coupled CysLT1 receptor in the nucleus of colorectal adenocarcinoma cells. | 2005 | Cancer Res. | pmid:15705869 |
| Trandafir CC et al. | Cysteinyl leukotrienes and leukotriene B mediate vasoconstriction to arginine vasopressin in rat basilar artery. | 2005 | Clin. Exp. Pharmacol. Physiol. | pmid:16445567 |
| Bochner BS and Busse WW | Allergy and asthma. | 2005 | J. Allergy Clin. Immunol. | pmid:15867851 |
| Parhamifar L et al. | Activation of cPLA2 is required for leukotriene D4-induced proliferation in colon cancer cells. | 2005 | Carcinogenesis | pmid:15975962 |
| Kumasawa F et al. | Apoptosis signal-regulating kinase 1 in leukotriene D(4)-induced activator protein-1 activation in airway smooth muscle cells. | 2005 | Eur. J. Pharmacol. | pmid:15970283 |
| Nagata M et al. | Effect of the cysteinyl leukotriene antagonist pranlukast on transendothelial migration of eosinophils. | 2005 | Int. Arch. Allergy Immunol. | pmid:15947477 |
| Kato Y et al. | Leukotriene D4 induces production of transforming growth factor-beta1 by eosinophils. | 2005 | Int. Arch. Allergy Immunol. | pmid:15947480 |
| Gauvreau GM et al. | Expression of functional cysteinyl leukotriene receptors by human basophils. | 2005 | J. Allergy Clin. Immunol. | pmid:15990778 |
| Fernandez J et al. | Isoquercitrin from Argemone platyceras inhibits carbachol and leukotriene D4-induced contraction in guinea-pig airways. | 2005 | Eur. J. Pharmacol. | pmid:16202993 |
| Casas A et al. | Leukotriene D4-induced hypoxaemia in asthma is mediated by the cys-leukotriene1 receptor. | 2005 | Eur. Respir. J. | pmid:16135725 |
| Gyllfors P et al. | Relation between bronchial responsiveness to inhaled leukotriene D4 and markers of leukotriene biosynthesis. | 2005 | Thorax | pmid:16055619 |