| MeSH term | MeSH ID | Detail |
|---|---|---|
| Airway Obstruction | D000402 | 13 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Inflammatory Bowel Diseases | D015212 | 9 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
LTD4
Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTD4?
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTD4
PubChem Associated disorders and diseases
What pathways are associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTD4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTD4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTD4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTD4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTD4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTD4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Paruchuri S and Sjölander A | Leukotriene D4 mediates survival and proliferation via separate but parallel pathways in the human intestinal epithelial cell line Int 407. | 2003 | J. Biol. Chem. | pmid:12912998 |
| Hoshino M et al. | Leukotriene D4 activates mitogen-activated protein kinase through a protein kinase Calpha-Raf-1-dependent pathway in human monocytic leukemia THP-1 cells. | 1998 | J. Biol. Chem. | pmid:9478929 |
| Bannenberg G et al. | Leukotriene C4 is a tight-binding inhibitor of microsomal glutathione transferase-1. Effects of leukotriene pathway modifiers. | 1999 | J. Biol. Chem. | pmid:9890956 |
| Metters KM and Zamboni RJ | Photoaffinity labeling of the leukotriene D4 receptor in guinea pig lung. | 1993 | J. Biol. Chem. | pmid:8384212 |
| Kimura K et al. | Modulation of platelet activating factor-induced glycogenolysis in the perfused rat liver after administration of endotoxin in vivo. | 1998 | J. Biochem. | pmid:9504421 |
| Ahmed T et al. | Inhibition of allergic late airway responses by inhaled heparin-derived oligosaccharides. | 2000 | J. Appl. Physiol. | pmid:10797135 |
| Omori C et al. | Eicosanoids modulate hyperpnea-induced bronchoconstriction in canine peripheral airways. | 1996 | J. Appl. Physiol. | pmid:8889761 |
| Nagase T et al. | Airway and tissue behavior during early response in sensitized rats: role of 5-HT and LTD4. | 1996 | J. Appl. Physiol. | pmid:8929602 |
| Yang XX et al. | Strain dependence of the airway response to dry-gas hyperpnea challenge in the rat. | 1999 | J. Appl. Physiol. | pmid:9887125 |
| Kondeti V et al. | Leukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3. | 2016 | J. Allergy Clin. Immunol. | pmid:26255103 |
| Reiss TF et al. | Effects of montelukast (MK-0476), a new potent cysteinyl leukotriene (LTD4) receptor antagonist, in patients with chronic asthma. | 1996 | J. Allergy Clin. Immunol. | pmid:8828530 |
| Woszczek G et al. | Leukotriene D(4) induces gene expression in human monocytes through cysteinyl leukotriene type I receptor. | 2008 | J. Allergy Clin. Immunol. | pmid:18028998 |
| Espinosa K et al. | CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4. | 2003 | J. Allergy Clin. Immunol. | pmid:12743568 |
| Parmentier CN et al. | Human T(H)2 cells respond to cysteinyl leukotrienes through selective expression of cysteinyl leukotriene receptor 1. | 2012 | J. Allergy Clin. Immunol. | pmid:22391114 |
| Crimi N et al. | Inhibitory effect of a leukotriene receptor antagonist (montelukast) on neurokinin A-induced bronchoconstriction. | 2003 | J. Allergy Clin. Immunol. | pmid:12704366 |
| Peters SP | Leukotriene receptor antagonists in asthma therapy. | 2003 | J. Allergy Clin. Immunol. | pmid:12532087 |
| Doherty TA et al. | Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production. | 2013 | J. Allergy Clin. Immunol. | pmid:23688412 |
| Guan W et al. | Leukotriene D4 and methacholine bronchial provocation tests for identifying leukotriene-responsiveness subtypes. | 2013 | J. Allergy Clin. Immunol. | pmid:23040886 |
| Thivierge M et al. | Toll-like receptor agonists differentially regulate cysteinyl-leukotriene receptor 1 expression and function in human dendritic cells. | 2006 | J. Allergy Clin. Immunol. | pmid:16675346 |
| Kawano T et al. | Cysteinyl leukotrienes induce nuclear factor kappa b activation and RANTES production in a murine model of asthma. | 2003 | J. Allergy Clin. Immunol. | pmid:12897744 |
| Yoshisue H et al. | Cysteinyl leukotrienes synergize with growth factors to induce proliferation of human bronchial fibroblasts. | 2007 | J. Allergy Clin. Immunol. | pmid:17208594 |
| Lee KS et al. | Cysteinyl leukotriene upregulates IL-11 expression in allergic airway disease of mice. | 2007 | J. Allergy Clin. Immunol. | pmid:17208595 |
| Lee TH et al. | Leukotriene E4: perspective on the forgotten mediator. | 2009 | J. Allergy Clin. Immunol. | pmid:19482346 |
| Austen KF et al. | The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications. | 2009 | J. Allergy Clin. Immunol. | pmid:19647860 |
| Asakura T et al. | Leukotriene D4 stimulates collagen production from myofibroblasts transformed by TGF-beta. | 2004 | J. Allergy Clin. Immunol. | pmid:15316508 |
| Rael E | Unraveling the complexity of leukotriene and prostaglandin inflammatory signaling. | 2016 | J. Allergy Clin. Immunol. | pmid:26518091 |
| Gyllfors P et al. | Bronchial responsiveness to leukotriene D4 is resistant to inhaled fluticasone propionate. | 2006 | J. Allergy Clin. Immunol. | pmid:16815141 |
| Braccioni F et al. | The effect of cysteinyl leukotrienes on growth of eosinophil progenitors from peripheral blood and bone marrow of atopic subjects. | 2002 | J. Allergy Clin. Immunol. | pmid:12110827 |
| Bandeira-Melo C et al. | Cysteinyl leukotrienes induce IL-4 release from cord blood-derived human eosinophils. | 2002 | J. Allergy Clin. Immunol. | pmid:12063527 |
| Bochner BS and Busse WW | Allergy and asthma. | 2005 | J. Allergy Clin. Immunol. | pmid:15867851 |
| Gauvreau GM et al. | Expression of functional cysteinyl leukotriene receptors by human basophils. | 2005 | J. Allergy Clin. Immunol. | pmid:15990778 |
| Salari H et al. | Involvement of immunologic mechanisms in a guinea pig model of western red cedar asthma. | 1994 | J. Allergy Clin. Immunol. | pmid:8182231 |
| Lamoureux J et al. | Leukotriene D4 enhances immunoglobulin production in CD40-activated human B lymphocytes. | 2006 | J. Allergy Clin. Immunol. | pmid:16630953 |
| Nagata M et al. | Leukotriene D4 upregulates eosinophil adhesion via the cysteinyl leukotriene 1 receptor. | 2002 | J. Allergy Clin. Immunol. | pmid:11941318 |
| Shimoda H et al. | Anti type I allergic property of Japanese butterbur extract and its mast cell degranulation inhibitory ingredients. | 2006 | J. Agric. Food Chem. | pmid:16608208 |
| Carlton RA et al. | Preparation and characterization of polymorphs for an LTD4 antagonist, RG 12525. | 1996 | J Pharm Sci | pmid:8742935 |
| Ramis I et al. | Application of totally automated on-line sample clean up system for extraction and high-performance liquid chromatography separation of peptide leukotrienes. | 1993 Nov-Dec | J Pharm Biomed Anal | pmid:8123725 |
| Chong K et al. | Drug substance manufacture process control: application of flow injection analysis and HPLC for monitoring an enantiospecific synthesis. | 1996 | J Pharm Biomed Anal | pmid:8895082 |
| Syslová K et al. | Immunomagnetic molecular probe with UHPLC-MS/MS: a promising way for reliable bronchial asthma diagnostics based on quantification of cysteinyl leukotrienes. | 2013 Jul-Aug | J Pharm Biomed Anal | pmid:23644905 |
| Huang XQ et al. | Transforming growth factor β1-induced astrocyte migration is mediated in part by activating 5-lipoxygenase and cysteinyl leukotriene receptor 1. | 2012 | J Neuroinflammation | pmid:22734808 |
| Herron DK et al. | Visualization and comparison of molecular dynamics simulations of leukotriene C4, leukotriene D4, and leukotriene E4. | 1995 | J Mol Graph | pmid:8820302 |
| Sanz ML et al. | Modulation of beta 2-adrenoceptors in human lymphocytes by in vitro stimulation with mediators. | 1994 May-Jun | J Investig Allergol Clin Immunol | pmid:7526943 |
| Schäper C et al. | Effects of fexofenadine on inflammatory mediators in nasal lavage fluid in intermittent allergic rhinitis. | 2009 | J Investig Allergol Clin Immunol | pmid:20128420 |
| Furukawa K et al. | Simplified sulfidoleukotriene ELISA using LTD4-conjugated phosphatase for the study of allergen-induced leukotriene generation by isolated mononuclear cells and diluted whole blood. | 1994 May-Jun | J Investig Allergol Clin Immunol | pmid:7981880 |
| O'Brien E et al. | Bisphenol A at concentrations relevant to human exposure enhances histamine and cysteinyl leukotriene release from bone marrow-derived mast cells. | 2014 Jan-Mar | J Immunotoxicol | pmid:23782309 |
| Inada T et al. | Intravenous anesthetic propofol suppresses prostaglandin E2 and cysteinyl leukotriene production and reduces edema formation in arachidonic acid-induced ear inflammation. | J Immunotoxicol | pmid:25046027 | |
| Campos MG et al. | Galphimia glauca organic fraction antagonizes LTD(4)-induced contraction in guinea pig airways. | 2001 | J Ethnopharmacol | pmid:11137344 |
| Mehta KA et al. | Effect of formulation and process variables on porosity parameters and release rates from a multi unit erosion matrix of a poorly soluble drug. | 2000 | J Control Release | pmid:10640593 |
| Kjellström S et al. | On-line coupling of microdialysis sampling with liquid chromatography for the determination of peptide and non-peptide leukotrienes. | 1998 | J Chromatogr A | pmid:9818423 |
| Suzuki M et al. | Inhibition of human eosinophil activation by a cysteinyl leukotriene receptor antagonist (pranlukast; ONO-1078). | 2003 | J Asthma | pmid:12870835 |