| MeSH term | MeSH ID | Detail |
|---|---|---|
| Airway Obstruction | D000402 | 13 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Inflammatory Bowel Diseases | D015212 | 9 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
LTD4
Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTD4?
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTD4
PubChem Associated disorders and diseases
What pathways are associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTD4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTD4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTD4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTD4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTD4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTD4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Soberman RJ and Christmas P | The organization and consequences of eicosanoid signaling. | 2003 | J. Clin. Invest. | pmid:12697726 |
| Crimi N et al. | Inhibitory effect of a leukotriene receptor antagonist (montelukast) on neurokinin A-induced bronchoconstriction. | 2003 | J. Allergy Clin. Immunol. | pmid:12704366 |
| Espinosa K et al. | CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4. | 2003 | J. Allergy Clin. Immunol. | pmid:12743568 |
| Murray J et al. | Role of leukotrienes in the regulation of human granulocyte behaviour: dissociation between agonist-induced activation and retardation of apoptosis. | 2003 | Br. J. Pharmacol. | pmid:12770944 |
| Vargaftig BB and Singer M | Leukotrienes mediate part of Ova-induced lung effects in mice via EGFR. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12794006 |
| Ichiyama T et al. | Pranlukast inhibits NF-kappa B activation in human monocytes/macrophages and T cells. | 2003 | Clin. Exp. Allergy | pmid:12801316 |
| Sylvin H et al. | Cysteinyl leukotrienes in porcine acute allergic airway reactions: bronchial and vascular effects. | 2003 | Inflamm. Res. | pmid:12813622 |
| Bouchelouche K et al. | The cysteinyl-leukotriene D4 induces cytosolic Ca2+ elevation and contraction of the human detrusor muscle. | 2003 | J. Urol. | pmid:12853847 |
| Potter-Perigo S et al. | Regulation of proteoglycan synthesis by leukotriene d4 and epidermal growth factor in bronchial smooth muscle cells. | 2004 | Am. J. Respir. Cell Mol. Biol. | pmid:12855404 |
| Mechiche H et al. | Effects of cysteinyl leukotrienes in small human bronchus and antagonist activity of montelukast and its metabolites. | 2003 | Clin. Exp. Allergy | pmid:12859443 |
| Schuhmann MU et al. | Temporal profiles of cerebrospinal fluid leukotrienes, brain edema and inflammatory response following experimental brain injury. | 2003 | Neurol. Res. | pmid:12866196 |
| Suzuki M et al. | Inhibition of human eosinophil activation by a cysteinyl leukotriene receptor antagonist (pranlukast; ONO-1078). | 2003 | J Asthma | pmid:12870835 |
| Kawano T et al. | Cysteinyl leukotrienes induce nuclear factor kappa b activation and RANTES production in a murine model of asthma. | 2003 | J. Allergy Clin. Immunol. | pmid:12897744 |
| Paruchuri S and Sjölander A | Leukotriene D4 mediates survival and proliferation via separate but parallel pathways in the human intestinal epithelial cell line Int 407. | 2003 | J. Biol. Chem. | pmid:12912998 |
| Sundström E et al. | Interactions among three classes of mediators explain antigen-induced bronchoconstriction in the isolated perfused and ventilated guinea pig lung. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12954791 |
| Schwartz JI et al. | Oral pharmacokinetics and food interaction of the leukotriene D4 receptor antagonist verlukast. | 1993 | Br J Clin Pharmacol | pmid:12959296 |
| Sugahara S et al. | Kinins are involved in the development of allergic nasal hyperresponsiveness in guinea pigs. | 2003 | Eur. J. Pharmacol. | pmid:12969770 |
| Massoumi R et al. | Leukotriene D4-induced adhesion of Caco-2 cells is mediated by prostaglandin E2 and upregulation of alpha2beta1-integrin. | 2003 | Exp. Cell Res. | pmid:14499635 |
| Thompson MD et al. | A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha. | 2003 | Pharmacogenetics | pmid:14515063 |
| Capra V et al. | Involvement of prenylated proteins in calcium signaling induced by LTD4 in differentiated U937 cells. | 2003 | Prostaglandins Other Lipid Mediat. | pmid:14518564 |