LTD4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTD4?

LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTD4

MeSH term MeSH ID Detail
Airway Obstruction D000402 13 associated lipids
Stomach Ulcer D013276 75 associated lipids
Adenocarcinoma D000230 166 associated lipids
Inflammation D007249 119 associated lipids
Inflammatory Bowel Diseases D015212 9 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Gastritis D005756 27 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTD4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTD4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTD4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTD4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTD4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTD4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTD4

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Authors Title Published Journal PubMed Link
Aoki M et al. Studies on mechanisms of low emetogenicity of YM976, a novel phosphodiesterase type 4 inhibitor. 2001 J. Pharmacol. Exp. Ther. pmid:11504812
Thivierge M et al. IL-13 and IL-4 up-regulate cysteinyl leukotriene 1 receptor expression in human monocytes and macrophages. 2001 J. Immunol. pmid:11509632
Nishimura H et al. Acute effects of prostaglandin D2 to induce airflow obstruction and airway microvascular leakage in guinea pigs: role of thromboxane A2 receptors. 2001 Prostaglandins Other Lipid Mediat. pmid:11519790
Hui Y et al. The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization. 2001 J. Biol. Chem. pmid:11591709
Ro JY et al. The inhibitory mechanism of rebamipide on the mediator release in the guinea pig lung mast cells activated with specific antigen-antibody reactions. 2001 Pharmacology pmid:11598424
Gauvreau GM et al. Inhaled leukotriene E(4), but not leukotriene D(4), increased airway inflammatory cells in subjects with atopic asthma. 2001 Am. J. Respir. Crit. Care Med. pmid:11704602
Martin V et al. Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors. 2001 Biochem. Pharmacol. pmid:11705452
Kawagishi Y et al. [Clinical significance of measurement of urinary leukotriene E4 in asthmatic patients without attack]. 2001 Arerugi pmid:11761885
Young RN Discovery of montelukast: a once-a-day oral antagonist of leukotriene D4 for the treatment of chronic asthma. 2001 Prog Med Chem pmid:11774796
Suzuki R and Freed AN Heparin inhibits hyperventilation-induced late-phase hyperreactivity in dogs. 2002 Am. J. Respir. Crit. Care Med. pmid:11779726