Lta4 is a lipid of Fatty Acyls (FA) class. Lta4 is associated with abnormalities such as Myocardial Infarction. The involved functions are known as enzyme activity, Mutation, Lipid Binding, Neutrophil Activation and Inflammation. Lta4 often locates in Membrane, Extracellular and Cytosol. The associated genes with LTA4 are Locus, ALOX5AP gene, CIITA gene and TNFSF4 gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTA4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTA4 is suspected in Myocardial Infarction and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with LTA4
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammation | D007249 | 119 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Esophageal Neoplasms | D004938 | 20 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Nasal Polyps | D009298 | 26 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Eosinophilic Esophagitis | D057765 | 3 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTA4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ahmad S et al. | Phosphorylation of Leukotriene C4 Synthase at Serine 36 Impairs Catalytic Activity. | 2016 | J. Biol. Chem. | pmid:27365393 |
| Abdul Roda M et al. | The matrikine PGP as a potential biomarker in COPD. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:26033353 |
| Dunstan SJ et al. | LTA4H genotype is associated with susceptibility to bacterial meningitis but is not a critical determinant of outcome. | 2015 | PLoS ONE | pmid:25799317 |
| Smyrniotis CJ et al. | ATP allosterically activates the human 5-lipoxygenase molecular mechanism of arachidonic acid and 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid. | 2014 | Biochemistry | pmid:24893149 |
| Paige M et al. | Role of leukotriene A4 hydrolase aminopeptidase in the pathogenesis of emphysema. | 2014 | J. Immunol. | pmid:24771855 |
| Niegowski D et al. | Crystal structures of leukotriene C4 synthase in complex with product analogs: implications for the enzyme mechanism. | 2014 | J. Biol. Chem. | pmid:24366866 |
| Bukiya AN et al. | Activation of calcium- and voltage-gated potassium channels of large conductance by leukotriene B4. | 2014 | J. Biol. Chem. | pmid:25371198 |
| Ringholz FC et al. | Reduced 15-lipoxygenase 2 and lipoxin A4/leukotriene B4 ratio in children with cystic fibrosis. | 2014 | Eur. Respir. J. | pmid:24696116 |
| Jin J et al. | Biosynthesis, isolation, and NMR analysis of leukotriene A epoxides: substrate chirality as a determinant of the cis or trans epoxide configuration. | 2013 | J. Lipid Res. | pmid:23242647 |
| Karelina TA et al. | Regulation of leukotriene and 5oxoETE synthesis and the effect of 5-lipoxygenase inhibitors: a mathematical modeling approach. | 2012 | BMC Syst Biol | pmid:23146124 |