| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Total
1
3-O-Methylquercetin
3-O-Methylquercetin is a lipid of Polyketides (PK) class. 3-o-methylquercetin is associated with abnormalities such as Colitis, Hemorrhagic diarrhea and Diabetes. The involved functions are known as Inflammation, Trans-Activation (Genetics), Signal Transduction, Binding, Competitive and Antiinflammatory Effect. 3-o-methylquercetin often locates in Mucous Membrane. The associated genes with 3-O-Methylquercetin are IL2 gene, Human gene and ABCB1 gene. The related experimental models are Streptozotocin Diabetes.
Cross Reference
Introduction
To understand associated biological information of 3-O-Methylquercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 3-O-Methylquercetin?
3-O-Methylquercetin is suspected in Colitis, Hemorrhagic diarrhea, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 3-O-Methylquercetin
PubChem Associated disorders and diseases
What pathways are associated with 3-O-Methylquercetin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 3-O-Methylquercetin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 3-O-Methylquercetin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 3-O-Methylquercetin?
There are no associated biomedical information in the current reference collection.
What genes are associated with 3-O-Methylquercetin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 3-O-Methylquercetin?
Streptozotocin Diabetes
Streptozotocin Diabetes are used in the study 'Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway.' (Dou W et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with 3-O-Methylquercetin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhao G et al. | Effects of solid dispersion and self-emulsifying formulations on the solubility, dissolution, permeability and pharmacokinetics of isorhamnetin, quercetin and kaempferol in total flavones of Hippophae rhamnoides L. | 2013 | Drug Dev Ind Pharm | pmid:22757776 |
| Saud SM et al. | Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and β-catenin. | 2013 | Cancer Res. | pmid:23824743 |
| He J et al. | A sensitive LC-MS/MS method for simultaneous determination of six flavonoids in rat plasma: application to a pharmacokinetic study of total flavonoids from mulberry leaves. | 2013 | J Pharm Biomed Anal | pmid:23850933 |
| Sun J et al. | Isorhamnetin protects against doxorubicin-induced cardiotoxicity in vivo and in vitro. | 2013 | PLoS ONE | pmid:23724057 |
| Sabini MC et al. | Evaluation of the cytotoxicity, genotoxicity and apoptotic induction of an aqueous extract of Achyrocline satureioides (Lam.) DC. | 2013 | Food Chem. Toxicol. | pmid:23948353 |
| Granica S et al. | Antioxidant and anti-inflammatory flavonol glucuronides from Polygonum aviculare L. | 2013 | Fitoterapia | pmid:24028968 |
| Xu SL et al. | Flavonoids induce the expression of synaptic proteins, synaptotagmin, and postsynaptic density protein-95 in cultured rat cortical neuron. | 2013 | Planta Med. | pmid:24243544 |
| Farag MA et al. | Metabolome classification of Brassica napus L. organs via UPLC-QTOF-PDA-MS and their anti-oxidant potential. | 2013 May-Jun | Phytochem Anal | pmid:23055344 |
| Dou W et al. | Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway. | 2014 | J. Nutr. Biochem. | pmid:24913217 |
| Seo K et al. | The antioxidant effects of isorhamnetin contribute to inhibit COX-2 expression in response to inflammation: a potential role of HO-1. | 2014 | Inflammation | pmid:24337631 |
| Yang JH et al. | Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24211276 |
| Li C et al. | Isorhamnetin suppresses colon cancer cell growth through the PI3K‑Akt‑mTOR pathway. | 2014 | Mol Med Rep | pmid:24398569 |
| Kawasaki T et al. | Components of foods inhibit a drug exporter, human multidrug and toxin extrusion transporter 1. | 2014 | Biol. Pharm. Bull. | pmid:24492725 |
| Bidone J et al. | Simultaneous quantification of flavonoids from Achyrocline satureioides by a polar-reversed phase LC method--application to skin permeation/retention studies. | 2014 | Pharmazie | pmid:24601216 |
| Somerset S and Papier K | A food frequency questionnaire validated for estimating dietary flavonoid intake in an Australian population. | 2014 | Nutr Cancer | pmid:25207829 |
| Kim B et al. | Eruca sativa and its flavonoid components, quercetin and isorhamnetin, improve skin barrier function by activation of peroxisome proliferator-activated receptor (PPAR)-α and suppression of inflammatory cytokines. | 2014 | Phytother Res | pmid:24610745 |
| Morris JB et al. | Flavonol content, oil%, and fatty acid composition variability in seeds of Teramnus labialis and T. uncinatus accessions with nutraceutical potential. | 2014 | J Diet Suppl | pmid:25054688 |
| Antunes-Ricardo M et al. | Induction of apoptosis in colon cancer cells treated with isorhamnetin glycosides from Opuntia ficus-indica pads. | 2014 | Plant Foods Hum Nutr | pmid:25186940 |
| Bakır T et al. | Antioxidant/prooxidant effects of α-tocopherol, quercetin and isorhamnetin on linoleic acid peroxidation induced by Cu(II) and H2O2. | 2014 | Int J Food Sci Nutr | pmid:24152374 |
| Perez A et al. | The flavonoid quercetin induces acute vasodilator effects in healthy volunteers: correlation with beta-glucuronidase activity. | 2014 | Pharmacol. Res. | pmid:25076013 |
| Dong GZ et al. | AMPK activation by isorhamnetin protects hepatocytes against oxidative stress and mitochondrial dysfunction. | 2014 | Eur. J. Pharmacol. | pmid:24972246 |
| Jayashankar B et al. | Supercritical extract of Seabuckthorn Leaves (SCE200ET) inhibited endotoxemia by reducing inflammatory cytokines and nitric oxide synthase 2 expression. | 2014 | Int. Immunopharmacol. | pmid:24594274 |
| Duan J et al. | Transport characteristics of isorhamnetin across intestinal Caco-2 cell monolayers and the effects of transporters on it. | 2014 | Food Chem. Toxicol. | pmid:24525098 |
| Xie Y et al. | Phytic acid enhances the oral absorption of isorhamnetin, quercetin, and kaempferol in total flavones of Hippophae rhamnoides L. | 2014 | Fitoterapia | pmid:24462958 |
| Kim JH et al. | Enzyme-assisted extraction of cactus bioactive molecules under high hydrostatic pressure. | 2014 | J. Sci. Food Agric. | pmid:23893871 |
| Fatima T et al. | Metabolite profiling and expression analysis of flavonoid, vitamin C and tocopherol biosynthesis genes in the antioxidant-rich sea buckthorn (Hippophae rhamnoides L.). | 2015 | Phytochemistry | pmid:26318327 |
| Hu S et al. | Isorhamnetin inhibits cell proliferation and induces apoptosis in breast cancer via Akt and mitogen‑activated protein kinase kinase signaling pathways. | 2015 | Mol Med Rep | pmid:26502751 |
| Park YJ et al. | Inhibitory Aromatase Effects of Flavonoids from Ginkgo Biloba Extracts on Estrogen Biosynthesis. | 2015 | Asian Pac. J. Cancer Prev. | pmid:26434836 |
| Ruan Y et al. | Autophagy inhibition enhances isorhamnetin‑induced mitochondria‑dependent apoptosis in non‑small cell lung cancer cells. | 2015 | Mol Med Rep | pmid:26238746 |
| Cariddi LN et al. | In Vitro and In Vivo Cytogenotoxic Effects of Hot Aqueous Extract of Achyrocline satureioides (Lam.) DC. | 2015 | Biomed Res Int | pmid:26078941 |
| Chen TL et al. | Protective effects of isorhamnetin on apoptosis and inflammation in TNF-α-induced HUVECs injury. | 2015 | Int J Clin Exp Pathol | pmid:26045738 |
| Sun Q et al. | Urinary Excretion of Select Dietary Polyphenol Metabolites Is Associated with a Lower Risk of Type 2 Diabetes in Proximate but Not Remote Follow-Up in a Prospective Investigation in 2 Cohorts of US Women. | 2015 | J. Nutr. | pmid:25904735 |
| Li Q et al. | Anti-proliferation effects of isorhamnetin on lung cancer cells in vitro and in vivo. | 2015 | Asian Pac. J. Cancer Prev. | pmid:25854402 |
| Antunes-Ricardo M et al. | Topical anti-inflammatory effects of isorhamnetin glycosides isolated from Opuntia ficus-indica. | 2015 | Biomed Res Int | pmid:25821823 |
| Abdal Dayem A et al. | Antiviral effect of methylated flavonol isorhamnetin against influenza. | 2015 | PLoS ONE | pmid:25806943 |
| Luo Y et al. | Isorhamnetin attenuates atherosclerosis by inhibiting macrophage apoptosis via PI3K/AKT activation and HO-1 induction. | 2015 | PLoS ONE | pmid:25799286 |
| Zhang BY et al. | Isorhamnetin flavonoid synergistically enhances the anticancer activity and apoptosis induction by cis-platin and carboplatin in non-small cell lung carcinoma (NSCLC). | 2015 | Int J Clin Exp Pathol | pmid:25755690 |
| Daubney J et al. | Cardioprotective and cardiotoxic effects of quercetin and two of its in vivo metabolites on differentiated h9c2 cardiomyocytes. | 2015 | Basic Clin. Pharmacol. Toxicol. | pmid:25203460 |
| Messer JG et al. | Quercetin Metabolites Up-Regulate the Antioxidant Response in Osteoblasts Isolated From Fetal Rat Calvaria. | 2015 | J. Cell. Biochem. | pmid:25716194 |
| Jimenez R et al. | Quercetin and its metabolites inhibit the membrane NADPH oxidase activity in vascular smooth muscle cells from normotensive and spontaneously hypertensive rats. | 2015 | Food Funct | pmid:25562607 |
| Sabbagh G and Berakdar N | Docking studies of flavonoid compounds as inhibitors of β-ketoacyl acyl carrier protein synthase I (Kas I) of Escherichia coli. | 2015 | J. Mol. Graph. Model. | pmid:26292066 |
| Li C et al. | Inhibitory Effects of Isorhamnetin on the Invasion of Human Breast Carcinoma Cells by Downregulating the Expression and Activity of Matrix Metalloproteinase-2/9. | 2015 | Nutr Cancer | pmid:26359917 |
| Iida A et al. | Protective effects of Nitraria retusa extract and its constituent isorhamnetin against amyloid β-induced cytotoxicity and amyloid β aggregation. | 2015 | Biosci. Biotechnol. Biochem. | pmid:25965116 |
| Maciej J et al. | Bioavailability of the flavonol quercetin in neonatal calves after oral administration of quercetin aglycone or rutin. | 2015 | J. Dairy Sci. | pmid:25795488 |
| Shaheen N et al. | Separation of isorhamnetin 3-sulphate and astragalin from Flaveria bidentis (L.) Kuntze using macroporous resin and followed by high-speed countercurrent chromatography. | 2015 | J Sep Sci | pmid:25763770 |
| Wiczkowski W et al. | Quercetin and isorhamnetin aglycones are the main metabolites of dietary quercetin in cerebrospinal fluid. | 2015 | Mol Nutr Food Res | pmid:25727325 |
| RodrÃguez-RodrÃguez C et al. | The effect of isorhamnetin glycosides extracted from Opuntia ficus-indica in a mouse model of diet induced obesity. | 2015 | Food Funct | pmid:25588195 |
| Wang H et al. | A phospholipid complex to improve the oral bioavailability of flavonoids. | 2015 | Drug Dev Ind Pharm | pmid:25496311 |
| Mihajlovic L et al. | Composition of polyphenol and polyamide compounds in common ragweed (Ambrosia artemisiifolia L.) pollen and sub-pollen particles. | 2015 | Phytochemistry | pmid:25468540 |
| Wang W et al. | Enhanced dissolution rate and oral bioavailability of Ginkgo biloba extract by preparing solid dispersion via hot-melt extrusion. | 2015 | Fitoterapia | pmid:25446043 |