| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Total
1
3-O-Methylquercetin
3-O-Methylquercetin is a lipid of Polyketides (PK) class. 3-o-methylquercetin is associated with abnormalities such as Colitis, Hemorrhagic diarrhea and Diabetes. The involved functions are known as Inflammation, Trans-Activation (Genetics), Signal Transduction, Binding, Competitive and Antiinflammatory Effect. 3-o-methylquercetin often locates in Mucous Membrane. The associated genes with 3-O-Methylquercetin are IL2 gene, Human gene and ABCB1 gene. The related experimental models are Streptozotocin Diabetes.
Cross Reference
Introduction
To understand associated biological information of 3-O-Methylquercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 3-O-Methylquercetin?
3-O-Methylquercetin is suspected in Colitis, Hemorrhagic diarrhea, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 3-O-Methylquercetin
PubChem Associated disorders and diseases
What pathways are associated with 3-O-Methylquercetin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 3-O-Methylquercetin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 3-O-Methylquercetin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 3-O-Methylquercetin?
There are no associated biomedical information in the current reference collection.
What genes are associated with 3-O-Methylquercetin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 3-O-Methylquercetin?
Streptozotocin Diabetes
Streptozotocin Diabetes are used in the study 'Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway.' (Dou W et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with 3-O-Methylquercetin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kim BG et al. | Multiple regiospecific methylations of a flavonoid by plant O-methyltransferases expressed in E. coli. | 2005 | Biotechnol. Lett. | pmid:16328980 |
| Wang JY et al. | Network pharmacological mechanisms of Vernonia anthelmintica (L.) in the treatment of vitiligo: Isorhamnetin induction of melanogenesis via up-regulation of melanin-biosynthetic genes. | 2017 | BMC Syst Biol | pmid:29145845 |
| Hubbard GP et al. | Ingestion of onion soup high in quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in man: a pilot study. | 2006 | Br. J. Nutr. | pmid:16925853 |
| Ford CT et al. | Identification of (poly)phenol treatments that modulate the release of pro-inflammatory cytokines by human lymphocytes. | 2016 | Br. J. Nutr. | pmid:26984113 |
| Cao J et al. | The relationship between fasting plasma concentrations of selected flavonoids and their ordinary dietary intake. | 2010 | Br. J. Nutr. | pmid:19747418 |
| Boesch-Saadatmandi C et al. | Effect of apoE genotype and dietary quercetin on blood lipids and TNF-alpha levels in apoE3 and apoE4 targeted gene replacement mice. | 2009 | Br. J. Nutr. | pmid:18986596 |
| Nishijima T et al. | Simultaneous ingestion of high-methoxy pectin from apple can enhance absorption of quercetin in human subjects. | 2015 | Br. J. Nutr. | pmid:25865751 |
| Egert S et al. | Enriched cereal bars are more effective in increasing plasma quercetin compared with quercetin from powder-filled hard capsules. | 2012 | Br. J. Nutr. | pmid:21774840 |
| Dragoni S et al. | Red wine alcohol promotes quercetin absorption and directs its metabolism towards isorhamnetin and tamarixetin in rat intestine in vitro. | 2006 | Br. J. Pharmacol. | pmid:16444288 |
| Lee HJ et al. | Mitochondria-cytochrome C-caspase-9 cascade mediates isorhamnetin-induced apoptosis. | 2008 | Cancer Lett. | pmid:18617322 |
| Manu KA et al. | Isorhamnetin augments the anti-tumor effect of capeciatbine through the negative regulation of NF-κB signaling cascade in gastric cancer. | 2015 | Cancer Lett. | pmid:25827070 |
| Kim JE et al. | Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K. | 2011 | Cancer Prev Res (Phila) | pmid:21330379 |
| Saud SM et al. | Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and β-catenin. | 2013 | Cancer Res. | pmid:23824743 |
| Li J et al. | Quercetin-3-methyl ether suppresses proliferation of mouse epidermal JB6 P+ cells by targeting ERKs. | 2012 | Carcinogenesis | pmid:22139441 |
| Zhu JX et al. | Quercetin, Kaempferol and Isorhamnetin in Elaeagnus pungens Thunb. Leaf: Pharmacological Activities and Quantitative Determination Studies. | 2018 | Chem. Biodivers. | pmid:29802806 |
| Ma G et al. | The flavonoid component isorhamnetin in vitro inhibits proliferation and induces apoptosis in Eca-109 cells. | 2007 | Chem. Biol. Interact. | pmid:17368593 |
| Ben Salah H et al. | Flavonol triglycosides from the leaves of Hammada scoparia (POMEL) ILJIN. | 2002 | Chem. Pharm. Bull. | pmid:12237550 |
| Neznanov N et al. | Quercetinase pirin makes poliovirus replication resistant to flavonoid quercetin. | 2008 | DNA Cell Biol. | pmid:18067462 |
| Zhao G et al. | Effects of solid dispersion and self-emulsifying formulations on the solubility, dissolution, permeability and pharmacokinetics of isorhamnetin, quercetin and kaempferol in total flavones of Hippophae rhamnoides L. | 2013 | Drug Dev Ind Pharm | pmid:22757776 |
| Wang H et al. | A phospholipid complex to improve the oral bioavailability of flavonoids. | 2015 | Drug Dev Ind Pharm | pmid:25496311 |
| Park JY et al. | Isorhamnetin-3-O-Glucuronide Suppresses JNK and p38 Activation and Increases Heme-Oxygenase-1 in Lipopolysaccharide-Challenged RAW264.7 Cells. | 2016 | Drug Dev. Res. | pmid:27113811 |
| Shukla SK et al. | Protection from radiation-induced mitochondrial and genomic DNA damage by an extract of Hippophae rhamnoides. | 2006 | Environ. Mol. Mutagen. | pmid:16948057 |
| Duan J et al. | A comparison of the pharmacokinetics of three different preparations of total flavones of Hippophae rhamnoides in beagle dogs after oral administration. | 2016 | Eur J Drug Metab Pharmacokinet | pmid:25613316 |
| Shi ZH et al. | Metabolism-based synthesis, biologic evaluation and SARs analysis of O-methylated analogs of quercetin as thrombin inhibitors. | 2012 | Eur J Med Chem | pmid:22647223 |
| Larmo PS et al. | Effect of a low dose of sea buckthorn berries on circulating concentrations of cholesterol, triacylglycerols, and flavonols in healthy adults. | 2009 | Eur J Nutr | pmid:19288149 |
| Burak C et al. | Higher plasma quercetin levels following oral administration of an onion skin extract compared with pure quercetin dihydrate in humans. | 2017 | Eur J Nutr | pmid:26482244 |
| Xie Y et al. | Comparison of isorhamnetin absorption properties in total flavones of Hippophae rhamnoides L. with its pure form in a Caco-2 cell model mediated by multidrug resistance-associated protein. | 2015 | Eur J Pharm Sci | pmid:25813735 |
| Bao M and Lou Y | Isorhamnetin prevent endothelial cell injuries from oxidized LDL via activation of p38MAPK. | 2006 | Eur. J. Pharmacol. | pmid:16963021 |
| Yang JH et al. | Isorhamnetin attenuates liver fibrosis by inhibiting TGF-β/Smad signaling and relieving oxidative stress. | 2016 | Eur. J. Pharmacol. | pmid:27151496 |
| Dong GZ et al. | AMPK activation by isorhamnetin protects hepatocytes against oxidative stress and mitochondrial dysfunction. | 2014 | Eur. J. Pharmacol. | pmid:24972246 |
| Li YC et al. | Luteolin Suppresses Inflammatory Mediator Expression by Blocking the Akt/NFκB Pathway in Acute Lung Injury Induced by Lipopolysaccharide in Mice. | 2012 | Evid Based Complement Alternat Med | pmid:22203870 |
| Zhang N et al. | Isorhamnetin protects rat ventricular myocytes from ischemia and reperfusion injury. | 2011 | Exp. Toxicol. Pathol. | pmid:19815400 |
| da Silva EL et al. | Quercetin metabolites inhibit copper ion-induced lipid peroxidation in rat plasma. | 1998 | FEBS Lett. | pmid:9688581 |
| Lall N et al. | Antiviral and antituberculous activity of Helichrysum melanacme constituents. | 2006 | Fitoterapia | pmid:16529879 |
| Krenn L et al. | Contribution of methylated exudate flavonoids to the anti-inflammatory activity of Grindelia robusta. | 2009 | Fitoterapia | pmid:19278665 |
| Granica S et al. | Antioxidant and anti-inflammatory flavonol glucuronides from Polygonum aviculare L. | 2013 | Fitoterapia | pmid:24028968 |
| Gudej J and Nazaruk J | Flavonol glycosides from the flowers of Bellis perennis. | 2001 | Fitoterapia | pmid:11677029 |
| Wang W et al. | Enhanced dissolution rate and oral bioavailability of Ginkgo biloba extract by preparing solid dispersion via hot-melt extrusion. | 2015 | Fitoterapia | pmid:25446043 |
| Chen ZP et al. | Comparative pharmacokinetics and bioavailability studies of quercetin, kaempferol and isorhamnetin after oral administration of Ginkgo biloba extracts, Ginkgo biloba extract phospholipid complexes and Ginkgo biloba extract solid dispersions in rats. | 2010 | Fitoterapia | pmid:20603197 |
| Xie Y et al. | Phytic acid enhances the oral absorption of isorhamnetin, quercetin, and kaempferol in total flavones of Hippophae rhamnoides L. | 2014 | Fitoterapia | pmid:24462958 |
| Li G et al. | Pharmacokinetic properties of isorhamnetin, kaempferol and quercetin after oral gavage of total flavones of Hippophae rhamnoides L. in rats using a UPLC-MS method. | 2012 | Fitoterapia | pmid:22056665 |
| Guo R et al. | Comparative assessment of phytochemical profiles, antioxidant and antiproliferative activities of Sea buckthorn (Hippophaë rhamnoides L.) berries. | 2017 | Food Chem | pmid:27979305 |
| Tian Y et al. | Phenolic compounds extracted by acidic aqueous ethanol from berries and leaves of different berry plants. | 2017 | Food Chem | pmid:27855899 |
| Mudrić SŽ et al. | The polyphenolics and carbohydrates as indicators of botanical and geographical origin of Serbian autochthonous clones of red spice paprika. | 2017 | Food Chem | pmid:27664689 |
| Ferreres F et al. | HPLC-DAD-ESI/MS(n) profiling of phenolic compounds from Lathyrus cicera L. seeds. | 2017 | Food Chem | pmid:27507525 |
| Mata A et al. | Contribution to the characterization of Opuntia spp. juices by LC-DAD-ESI-MS/MS. | 2016 | Food Chem | pmid:27211682 |
| Juániz I et al. | Influence of heat treatment on antioxidant capacity and (poly)phenolic compounds of selected vegetables. | 2016 | Food Chem | pmid:26616976 |
| Liu H et al. | Solid-phase extraction of flavonoids in honey samples using carbamate-embedded triacontyl-modified silica sorbent. | 2016 | Food Chem | pmid:26988475 |
| Choi KC et al. | Inhibitory effects of quercetin on aflatoxin B1-induced hepatic damage in mice. | 2010 | Food Chem. Toxicol. | pmid:20621152 |
| Sabini MC et al. | Evaluation of the cytotoxicity, genotoxicity and apoptotic induction of an aqueous extract of Achyrocline satureioides (Lam.) DC. | 2013 | Food Chem. Toxicol. | pmid:23948353 |