MeSH term | MeSH ID | Detail |
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Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
3-O-Methylquercetin is a lipid of Polyketides (PK) class. 3-o-methylquercetin is associated with abnormalities such as Colitis, Hemorrhagic diarrhea and Diabetes. The involved functions are known as Inflammation, Trans-Activation (Genetics), Signal Transduction, Binding, Competitive and Antiinflammatory Effect. 3-o-methylquercetin often locates in Mucous Membrane. The associated genes with 3-O-Methylquercetin are IL2 gene, Human gene and ABCB1 gene. The related experimental models are Streptozotocin Diabetes.
To understand associated biological information of 3-O-Methylquercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
3-O-Methylquercetin is suspected in Colitis, Hemorrhagic diarrhea, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 3-O-Methylquercetin
MeSH term | MeSH ID | Detail |
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Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Streptozotocin Diabetes are used in the study 'Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway.' (Dou W et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Jin JY et al. | Isorhamnetin inhibits Prevotella intermedia lipopolysaccharide-induced production of interleukin-6 in murine macrophages via anti-inflammatory heme oxygenase-1 induction and inhibition of nuclear factor-κB and signal transducer and activator of transcription 1 activation. | 2013 | J. Periodont. Res. | pmid:23441850 |
Gohlke A et al. | Bioavailability of quercetin from its aglycone and its glucorhamnoside rutin in lactating dairy cows after intraduodenal administration. | 2013 | J. Dairy Sci. | pmid:23403185 |
Saud SM et al. | Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and β-catenin. | 2013 | Cancer Res. | pmid:23824743 |
Fang R et al. | Enhanced profiling of flavonol glycosides in the fruits of sea buckthorn (Hippophae rhamnoides). | 2013 | J. Agric. Food Chem. | pmid:23517173 |
Ferreres F et al. | Phenolic compounds from Jacaranda caroba (Vell.) A. DC.: approaches to neurodegenerative disorders. | 2013 | Food Chem. Toxicol. | pmid:23524314 |
Yang JH et al. | O-Methylated flavonol isorhamnetin prevents acute inflammation through blocking of NF-κB activation. | 2013 | Food Chem. Toxicol. | pmid:23774260 |
Sun J et al. | Isorhamnetin protects against doxorubicin-induced cardiotoxicity in vivo and in vitro. | 2013 | PLoS ONE | pmid:23724057 |
Farag MA et al. | Metabolome classification of Brassica napus L. organs via UPLC-QTOF-PDA-MS and their anti-oxidant potential. | 2013 May-Jun | Phytochem Anal | pmid:23055344 |
Dou W et al. | Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway. | 2014 | J. Nutr. Biochem. | pmid:24913217 |
Seo K et al. | The antioxidant effects of isorhamnetin contribute to inhibit COX-2 expression in response to inflammation: a potential role of HO-1. | 2014 | Inflammation | pmid:24337631 |
Yang JH et al. | Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24211276 |
Li C et al. | Isorhamnetin suppresses colon cancer cell growth through the PI3K‑Akt‑mTOR pathway. | 2014 | Mol Med Rep | pmid:24398569 |
Kawasaki T et al. | Components of foods inhibit a drug exporter, human multidrug and toxin extrusion transporter 1. | 2014 | Biol. Pharm. Bull. | pmid:24492725 |
Bidone J et al. | Simultaneous quantification of flavonoids from Achyrocline satureioides by a polar-reversed phase LC method--application to skin permeation/retention studies. | 2014 | Pharmazie | pmid:24601216 |
Somerset S and Papier K | A food frequency questionnaire validated for estimating dietary flavonoid intake in an Australian population. | 2014 | Nutr Cancer | pmid:25207829 |
Kim B et al. | Eruca sativa and its flavonoid components, quercetin and isorhamnetin, improve skin barrier function by activation of peroxisome proliferator-activated receptor (PPAR)-α and suppression of inflammatory cytokines. | 2014 | Phytother Res | pmid:24610745 |
Morris JB et al. | Flavonol content, oil%, and fatty acid composition variability in seeds of Teramnus labialis and T. uncinatus accessions with nutraceutical potential. | 2014 | J Diet Suppl | pmid:25054688 |
Antunes-Ricardo M et al. | Induction of apoptosis in colon cancer cells treated with isorhamnetin glycosides from Opuntia ficus-indica pads. | 2014 | Plant Foods Hum Nutr | pmid:25186940 |
Bakır T et al. | Antioxidant/prooxidant effects of α-tocopherol, quercetin and isorhamnetin on linoleic acid peroxidation induced by Cu(II) and H2O2. | 2014 | Int J Food Sci Nutr | pmid:24152374 |
Perez A et al. | The flavonoid quercetin induces acute vasodilator effects in healthy volunteers: correlation with beta-glucuronidase activity. | 2014 | Pharmacol. Res. | pmid:25076013 |
Dong GZ et al. | AMPK activation by isorhamnetin protects hepatocytes against oxidative stress and mitochondrial dysfunction. | 2014 | Eur. J. Pharmacol. | pmid:24972246 |
Jayashankar B et al. | Supercritical extract of Seabuckthorn Leaves (SCE200ET) inhibited endotoxemia by reducing inflammatory cytokines and nitric oxide synthase 2 expression. | 2014 | Int. Immunopharmacol. | pmid:24594274 |
Duan J et al. | Transport characteristics of isorhamnetin across intestinal Caco-2 cell monolayers and the effects of transporters on it. | 2014 | Food Chem. Toxicol. | pmid:24525098 |
Xie Y et al. | Phytic acid enhances the oral absorption of isorhamnetin, quercetin, and kaempferol in total flavones of Hippophae rhamnoides L. | 2014 | Fitoterapia | pmid:24462958 |
Kim JH et al. | Enzyme-assisted extraction of cactus bioactive molecules under high hydrostatic pressure. | 2014 | J. Sci. Food Agric. | pmid:23893871 |
Fatima T et al. | Metabolite profiling and expression analysis of flavonoid, vitamin C and tocopherol biosynthesis genes in the antioxidant-rich sea buckthorn (Hippophae rhamnoides L.). | 2015 | Phytochemistry | pmid:26318327 |
Hu S et al. | Isorhamnetin inhibits cell proliferation and induces apoptosis in breast cancer via Akt and mitogen‑activated protein kinase kinase signaling pathways. | 2015 | Mol Med Rep | pmid:26502751 |
Park YJ et al. | Inhibitory Aromatase Effects of Flavonoids from Ginkgo Biloba Extracts on Estrogen Biosynthesis. | 2015 | Asian Pac. J. Cancer Prev. | pmid:26434836 |
Ruan Y et al. | Autophagy inhibition enhances isorhamnetin‑induced mitochondria‑dependent apoptosis in non‑small cell lung cancer cells. | 2015 | Mol Med Rep | pmid:26238746 |
Cariddi LN et al. | In Vitro and In Vivo Cytogenotoxic Effects of Hot Aqueous Extract of Achyrocline satureioides (Lam.) DC. | 2015 | Biomed Res Int | pmid:26078941 |
Chen TL et al. | Protective effects of isorhamnetin on apoptosis and inflammation in TNF-α-induced HUVECs injury. | 2015 | Int J Clin Exp Pathol | pmid:26045738 |
Sun Q et al. | Urinary Excretion of Select Dietary Polyphenol Metabolites Is Associated with a Lower Risk of Type 2 Diabetes in Proximate but Not Remote Follow-Up in a Prospective Investigation in 2 Cohorts of US Women. | 2015 | J. Nutr. | pmid:25904735 |
Li Q et al. | Anti-proliferation effects of isorhamnetin on lung cancer cells in vitro and in vivo. | 2015 | Asian Pac. J. Cancer Prev. | pmid:25854402 |
Antunes-Ricardo M et al. | Topical anti-inflammatory effects of isorhamnetin glycosides isolated from Opuntia ficus-indica. | 2015 | Biomed Res Int | pmid:25821823 |
Abdal Dayem A et al. | Antiviral effect of methylated flavonol isorhamnetin against influenza. | 2015 | PLoS ONE | pmid:25806943 |
Messer JG et al. | Quercetin Metabolites Up-Regulate the Antioxidant Response in Osteoblasts Isolated From Fetal Rat Calvaria. | 2015 | J. Cell. Biochem. | pmid:25716194 |
Jimenez R et al. | Quercetin and its metabolites inhibit the membrane NADPH oxidase activity in vascular smooth muscle cells from normotensive and spontaneously hypertensive rats. | 2015 | Food Funct | pmid:25562607 |
Sabbagh G and Berakdar N | Docking studies of flavonoid compounds as inhibitors of β-ketoacyl acyl carrier protein synthase I (Kas I) of Escherichia coli. | 2015 | J. Mol. Graph. Model. | pmid:26292066 |
Li C et al. | Inhibitory Effects of Isorhamnetin on the Invasion of Human Breast Carcinoma Cells by Downregulating the Expression and Activity of Matrix Metalloproteinase-2/9. | 2015 | Nutr Cancer | pmid:26359917 |
Iida A et al. | Protective effects of Nitraria retusa extract and its constituent isorhamnetin against amyloid β-induced cytotoxicity and amyloid β aggregation. | 2015 | Biosci. Biotechnol. Biochem. | pmid:25965116 |
Nishijima T et al. | Simultaneous ingestion of high-methoxy pectin from apple can enhance absorption of quercetin in human subjects. | 2015 | Br. J. Nutr. | pmid:25865751 |
Manu KA et al. | Isorhamnetin augments the anti-tumor effect of capeciatbine through the negative regulation of NF-κB signaling cascade in gastric cancer. | 2015 | Cancer Lett. | pmid:25827070 |
Xie Y et al. | Comparison of isorhamnetin absorption properties in total flavones of Hippophae rhamnoides L. with its pure form in a Caco-2 cell model mediated by multidrug resistance-associated protein. | 2015 | Eur J Pharm Sci | pmid:25813735 |
Maciej J et al. | Bioavailability of the flavonol quercetin in neonatal calves after oral administration of quercetin aglycone or rutin. | 2015 | J. Dairy Sci. | pmid:25795488 |
Shaheen N et al. | Separation of isorhamnetin 3-sulphate and astragalin from Flaveria bidentis (L.) Kuntze using macroporous resin and followed by high-speed countercurrent chromatography. | 2015 | J Sep Sci | pmid:25763770 |
Wiczkowski W et al. | Quercetin and isorhamnetin aglycones are the main metabolites of dietary quercetin in cerebrospinal fluid. | 2015 | Mol Nutr Food Res | pmid:25727325 |
RodrÃguez-RodrÃguez C et al. | The effect of isorhamnetin glycosides extracted from Opuntia ficus-indica in a mouse model of diet induced obesity. | 2015 | Food Funct | pmid:25588195 |
Wang H et al. | A phospholipid complex to improve the oral bioavailability of flavonoids. | 2015 | Drug Dev Ind Pharm | pmid:25496311 |
Mihajlovic L et al. | Composition of polyphenol and polyamide compounds in common ragweed (Ambrosia artemisiifolia L.) pollen and sub-pollen particles. | 2015 | Phytochemistry | pmid:25468540 |
Wang W et al. | Enhanced dissolution rate and oral bioavailability of Ginkgo biloba extract by preparing solid dispersion via hot-melt extrusion. | 2015 | Fitoterapia | pmid:25446043 |