| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Total
1
3-O-Methylquercetin
3-O-Methylquercetin is a lipid of Polyketides (PK) class. 3-o-methylquercetin is associated with abnormalities such as Colitis, Hemorrhagic diarrhea and Diabetes. The involved functions are known as Inflammation, Trans-Activation (Genetics), Signal Transduction, Binding, Competitive and Antiinflammatory Effect. 3-o-methylquercetin often locates in Mucous Membrane. The associated genes with 3-O-Methylquercetin are IL2 gene, Human gene and ABCB1 gene. The related experimental models are Streptozotocin Diabetes.
Cross Reference
Introduction
To understand associated biological information of 3-O-Methylquercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 3-O-Methylquercetin?
3-O-Methylquercetin is suspected in Colitis, Hemorrhagic diarrhea, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 3-O-Methylquercetin
PubChem Associated disorders and diseases
What pathways are associated with 3-O-Methylquercetin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 3-O-Methylquercetin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 3-O-Methylquercetin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 3-O-Methylquercetin?
There are no associated biomedical information in the current reference collection.
What genes are associated with 3-O-Methylquercetin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 3-O-Methylquercetin?
Streptozotocin Diabetes
Streptozotocin Diabetes are used in the study 'Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway.' (Dou W et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with 3-O-Methylquercetin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Czeczot H | The effect of flavonoids on the mutagenic activity of aromatic amines. | 1992 | Acta Biochim. Pol. | pmid:1441824 |
| Czeczot H and Kusztelak J | A study of the genotoxic potential of flavonoids using short-term bacterial assays. | 1993 | Acta Biochim. Pol. | pmid:8140830 |
| Lan K et al. | Intra-herb pharmacokinetics interaction between quercetin and isorhamentin. | 2008 | Acta Pharmacol. Sin. | pmid:18954533 |
| Smolarz HD | Comparative study on the free flavonoid aglycones in herbs of different species of Polygonum L. | 2002 Mar-Apr | Acta Pol Pharm | pmid:12365607 |
| Nazaruk J and Gudej J | Qualitative and quantitative chromatographic investigation of flavonoids in Bellis perennis L. | 2001 Sep-Oct | Acta Pol Pharm | pmid:11876448 |
| Sikorska M and Matławska I | Kaempferol, isorhamnetin and their glycosides in the flowers of Asclepias syriaca L. | 2001 Jul-Aug | Acta Pol Pharm | pmid:11693731 |
| Zhang XQ et al. | In vitro antioxidant and in vivo anti-inflammatory activities of Ophioglossum thermale. | 2012 | Am. J. Chin. Med. | pmid:22419423 |
| Morand C et al. | Plasma metabolites of quercetin and their antioxidant properties. | 1998 | Am. J. Physiol. | pmid:9688981 |
| Hoek-van den Hil EF et al. | Interference of flavonoids with enzymatic assays for the determination of free fatty acid and triglyceride levels. | 2012 | Anal Bioanal Chem | pmid:22119999 |
| Robin V et al. | Antipoliovirus flavonoids from Psiadia dentata. | 2001 | Antivir. Chem. Chemother. | pmid:11900347 |
| Lopez Pila JM et al. | Lack of evidence for strand-specific inhibition of poliovirus RNA synthesis by 3-methylquercetin. | 1989 | Antiviral Res. | pmid:2540709 |
| Vrijsen R et al. | The poliovirus-induced shut-off of cellular protein synthesis persists in the presence of 3-methylquercetin, a flavonoid which blocks viral protein and RNA synthesis. | 1987 | Antiviral Res. | pmid:3026245 |
| Rombaut B et al. | Comparison of arildone and 3-methylquercetin as stabilizers of poliovirus. | 1985 | Antiviral Res. | pmid:3002268 |
| Khouri HE et al. | Enzymatic synthesis of polymethylated flavonols in Chrysosplenium americanum. III. Purification and kinetic analysis of S-adenosyl-L-methionine:3-methylquercetin 7-O-methyltransferase. | 1988 | Arch. Biochem. Biophys. | pmid:3415239 |
| Murota K et al. | Efficiency of absorption and metabolic conversion of quercetin and its glucosides in human intestinal cell line Caco-2. | 2000 | Arch. Biochem. Biophys. | pmid:11368329 |
| Lu HW et al. | Effect of three flavonoids, 5,7,3',4'-tetrahydroxy-3-methoxy flavone, luteolin, and quercetin, on the stimulus-induced superoxide generation and tyrosyl phosphorylation of proteins in human neutrophil. | 2001 | Arch. Biochem. Biophys. | pmid:11516163 |
| Steffen Y et al. | Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase. | 2008 | Arch. Biochem. Biophys. | pmid:17996190 |
| Justino GC et al. | Plasma quercetin metabolites: structure-antioxidant activity relationships. | 2004 | Arch. Biochem. Biophys. | pmid:15519302 |
| Boers F et al. | An improved synthesis of the anti-picornavirus flavone 3-O-methylquercetin. | 1997 | Arch. Pharm. (Weinheim) | pmid:9396391 |
| Hyun SK et al. | Isorhamnetin glycosides with free radical and ONOO-scavenging activities from the stamens of Nelumbo nucifera. | 2006 | Arch. Pharm. Res. | pmid:16681033 |
| Ressaissi A et al. | Isorhamnetin derivatives and piscidic acid for hypercholesterolemia: cholesterol permeability, HMG-CoA reductase inhibition, and docking studies. | 2017 | Arch. Pharm. Res. | pmid:28936788 |
| Choi JS et al. | Further isolation of peroxynitrite and 1,1-diphenyl-2-picrylhydrazyl radical scavenging isorhamnetin 7-O-glucoside from the leaves of Brassica juncea L. | 2002 | Arch. Pharm. Res. | pmid:12433194 |
| Oh HM et al. | Inhibitory activity of isorhamnetin from Persicaria thunbergii on Farnesyl Protein Transferase. | 2005 | Arch. Pharm. Res. | pmid:15789745 |
| Schulz HU et al. | Investigation of pharmacokinetic data of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin revealed from single and multiple oral dose studies with a hypericum extract containing tablet in healthy male volunteers. | 2005 | Arzneimittelforschung | pmid:16294501 |
| Schulz HU et al. | Investigation of the bioavailability of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin following single and multiple oral dosing of a hypericum extract containing tablet. | 2005 | Arzneimittelforschung | pmid:15727160 |
| Park YJ et al. | Inhibitory Aromatase Effects of Flavonoids from Ginkgo Biloba Extracts on Estrogen Biosynthesis. | 2015 | Asian Pac. J. Cancer Prev. | pmid:26434836 |
| Li Q et al. | Anti-proliferation effects of isorhamnetin on lung cancer cells in vitro and in vivo. | 2015 | Asian Pac. J. Cancer Prev. | pmid:25854402 |
| Winterbone MS et al. | Physiologically relevant metabolites of quercetin have no effect on adhesion molecule or chemokine expression in human vascular smooth muscle cells. | 2009 | Atherosclerosis | pmid:18489909 |
| Lodi F et al. | Glucuronidated and sulfated metabolites of the flavonoid quercetin prevent endothelial dysfunction but lack direct vasorelaxant effects in rat aorta. | 2009 | Atherosclerosis | pmid:18801486 |
| Romero M et al. | Quercetin inhibits vascular superoxide production induced by endothelin-1: Role of NADPH oxidase, uncoupled eNOS and PKC. | 2009 | Atherosclerosis | pmid:18436224 |
| Daubney J et al. | Cardioprotective and cardiotoxic effects of quercetin and two of its in vivo metabolites on differentiated h9c2 cardiomyocytes. | 2015 | Basic Clin. Pharmacol. Toxicol. | pmid:25203460 |
| Piskula MK | Factors affecting flavonoids absorption. | 2000 | Biofactors | pmid:11216483 |
| Morand C et al. | Respective bioavailability of quercetin aglycone and its glycosides in a rat model. | 2000 | Biofactors | pmid:11216481 |
| Seo S et al. | Isorhamnetin Inhibits Reactive Oxygen Species-Dependent Hypoxia Inducible Factor (HIF)-1α Accumulation. | 2016 | Biol. Pharm. Bull. | pmid:27803454 |
| Kawasaki T et al. | Components of foods inhibit a drug exporter, human multidrug and toxin extrusion transporter 1. | 2014 | Biol. Pharm. Bull. | pmid:24492725 |
| Enomoto S et al. | Inhibitory effect of traditional Turkish folk medicines on aldose reductase (AR) and hematological activity, and on AR inhibitory activity of quercetin-3-O-methyl ether isolated from Cistus laurifolius L. | 2004 | Biol. Pharm. Bull. | pmid:15256757 |
| Lee YS et al. | Inhibitory effects of isorhamnetin-3-O-beta-D-glucoside from Salicornia herbacea on rat lens aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues. | 2005 | Biol. Pharm. Bull. | pmid:15863906 |
| Cariddi LN et al. | In Vitro and In Vivo Cytogenotoxic Effects of Hot Aqueous Extract of Achyrocline satureioides (Lam.) DC. | 2015 | Biomed Res Int | pmid:26078941 |
| Antunes-Ricardo M et al. | Topical anti-inflammatory effects of isorhamnetin glycosides isolated from Opuntia ficus-indica. | 2015 | Biomed Res Int | pmid:25821823 |
| Wang Z et al. | Simultaneous determination of six herbal components in intestinal perfusate by high-performance liquid chromatography. | 2009 | Biomed. Chromatogr. | pmid:19309764 |
| Qiu L et al. | Protective effects of isorhamnetin on N2a cell against endoplasmic reticulum stress-induced injury is mediated by PKCε. | 2017 | Biomed. Pharmacother. | pmid:28715866 |
| Lu X et al. | Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice. | 2018 | Biomed. Pharmacother. | pmid:29684859 |
| Kim JY et al. | In vitro anti-inflammatory activity of 3-O-methyl-flavones isolated from Siegesbeckia glabrescens. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18178435 |
| Si YX et al. | Effects of isorhamnetin on tyrosinase: inhibition kinetics and computational simulation. | 2012 | Biosci. Biotechnol. Biochem. | pmid:22790928 |
| Igarashi K and Ohmuma M | Effects of isorhamnetin, rhamnetin, and quercetin on the concentrations of cholesterol and lipoperoxide in the serum and liver and on the blood and liver antioxidative enzyme activities of rats. | 1995 | Biosci. Biotechnol. Biochem. | pmid:7772823 |
| Kawai Y et al. | Different profiles of quercetin metabolites in rat plasma: comparison of two administration methods. | 2009 | Biosci. Biotechnol. Biochem. | pmid:19270373 |
| Azuma K et al. | Enhancing effect of lipids and emulsifiers on the accumulation of quercetin metabolites in blood plasma after the short-term ingestion of onion by rats. | 2003 | Biosci. Biotechnol. Biochem. | pmid:14730132 |
| Iida A et al. | Protective effects of Nitraria retusa extract and its constituent isorhamnetin against amyloid β-induced cytotoxicity and amyloid β aggregation. | 2015 | Biosci. Biotechnol. Biochem. | pmid:25965116 |
| Saito A et al. | Protective effects of quercetin and its metabolites on H2O2-induced chromosomal damage to WIL2-NS cells. | 2004 | Biosci. Biotechnol. Biochem. | pmid:14981287 |
| Kim BG et al. | Multiple regiospecific methylations of a flavonoid by plant O-methyltransferases expressed in E. coli. | 2005 | Biotechnol. Lett. | pmid:16328980 |
| Wang JY et al. | Network pharmacological mechanisms of Vernonia anthelmintica (L.) in the treatment of vitiligo: Isorhamnetin induction of melanogenesis via up-regulation of melanin-biosynthetic genes. | 2017 | BMC Syst Biol | pmid:29145845 |
| Hubbard GP et al. | Ingestion of onion soup high in quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in man: a pilot study. | 2006 | Br. J. Nutr. | pmid:16925853 |
| Ford CT et al. | Identification of (poly)phenol treatments that modulate the release of pro-inflammatory cytokines by human lymphocytes. | 2016 | Br. J. Nutr. | pmid:26984113 |
| Cao J et al. | The relationship between fasting plasma concentrations of selected flavonoids and their ordinary dietary intake. | 2010 | Br. J. Nutr. | pmid:19747418 |
| Boesch-Saadatmandi C et al. | Effect of apoE genotype and dietary quercetin on blood lipids and TNF-alpha levels in apoE3 and apoE4 targeted gene replacement mice. | 2009 | Br. J. Nutr. | pmid:18986596 |
| Nishijima T et al. | Simultaneous ingestion of high-methoxy pectin from apple can enhance absorption of quercetin in human subjects. | 2015 | Br. J. Nutr. | pmid:25865751 |
| Egert S et al. | Enriched cereal bars are more effective in increasing plasma quercetin compared with quercetin from powder-filled hard capsules. | 2012 | Br. J. Nutr. | pmid:21774840 |
| Dragoni S et al. | Red wine alcohol promotes quercetin absorption and directs its metabolism towards isorhamnetin and tamarixetin in rat intestine in vitro. | 2006 | Br. J. Pharmacol. | pmid:16444288 |
| Lee HJ et al. | Mitochondria-cytochrome C-caspase-9 cascade mediates isorhamnetin-induced apoptosis. | 2008 | Cancer Lett. | pmid:18617322 |
| Manu KA et al. | Isorhamnetin augments the anti-tumor effect of capeciatbine through the negative regulation of NF-κB signaling cascade in gastric cancer. | 2015 | Cancer Lett. | pmid:25827070 |
| Kim JE et al. | Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K. | 2011 | Cancer Prev Res (Phila) | pmid:21330379 |
| Saud SM et al. | Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and β-catenin. | 2013 | Cancer Res. | pmid:23824743 |
| Li J et al. | Quercetin-3-methyl ether suppresses proliferation of mouse epidermal JB6 P+ cells by targeting ERKs. | 2012 | Carcinogenesis | pmid:22139441 |
| Zhu JX et al. | Quercetin, Kaempferol and Isorhamnetin in Elaeagnus pungens Thunb. Leaf: Pharmacological Activities and Quantitative Determination Studies. | 2018 | Chem. Biodivers. | pmid:29802806 |
| Ma G et al. | The flavonoid component isorhamnetin in vitro inhibits proliferation and induces apoptosis in Eca-109 cells. | 2007 | Chem. Biol. Interact. | pmid:17368593 |
| Ben Salah H et al. | Flavonol triglycosides from the leaves of Hammada scoparia (POMEL) ILJIN. | 2002 | Chem. Pharm. Bull. | pmid:12237550 |
| Neznanov N et al. | Quercetinase pirin makes poliovirus replication resistant to flavonoid quercetin. | 2008 | DNA Cell Biol. | pmid:18067462 |
| Zhao G et al. | Effects of solid dispersion and self-emulsifying formulations on the solubility, dissolution, permeability and pharmacokinetics of isorhamnetin, quercetin and kaempferol in total flavones of Hippophae rhamnoides L. | 2013 | Drug Dev Ind Pharm | pmid:22757776 |
| Wang H et al. | A phospholipid complex to improve the oral bioavailability of flavonoids. | 2015 | Drug Dev Ind Pharm | pmid:25496311 |
| Park JY et al. | Isorhamnetin-3-O-Glucuronide Suppresses JNK and p38 Activation and Increases Heme-Oxygenase-1 in Lipopolysaccharide-Challenged RAW264.7 Cells. | 2016 | Drug Dev. Res. | pmid:27113811 |
| Shukla SK et al. | Protection from radiation-induced mitochondrial and genomic DNA damage by an extract of Hippophae rhamnoides. | 2006 | Environ. Mol. Mutagen. | pmid:16948057 |
| Duan J et al. | A comparison of the pharmacokinetics of three different preparations of total flavones of Hippophae rhamnoides in beagle dogs after oral administration. | 2016 | Eur J Drug Metab Pharmacokinet | pmid:25613316 |
| Shi ZH et al. | Metabolism-based synthesis, biologic evaluation and SARs analysis of O-methylated analogs of quercetin as thrombin inhibitors. | 2012 | Eur J Med Chem | pmid:22647223 |
| Larmo PS et al. | Effect of a low dose of sea buckthorn berries on circulating concentrations of cholesterol, triacylglycerols, and flavonols in healthy adults. | 2009 | Eur J Nutr | pmid:19288149 |
| Burak C et al. | Higher plasma quercetin levels following oral administration of an onion skin extract compared with pure quercetin dihydrate in humans. | 2017 | Eur J Nutr | pmid:26482244 |
| Xie Y et al. | Comparison of isorhamnetin absorption properties in total flavones of Hippophae rhamnoides L. with its pure form in a Caco-2 cell model mediated by multidrug resistance-associated protein. | 2015 | Eur J Pharm Sci | pmid:25813735 |
| Bao M and Lou Y | Isorhamnetin prevent endothelial cell injuries from oxidized LDL via activation of p38MAPK. | 2006 | Eur. J. Pharmacol. | pmid:16963021 |
| Yang JH et al. | Isorhamnetin attenuates liver fibrosis by inhibiting TGF-β/Smad signaling and relieving oxidative stress. | 2016 | Eur. J. Pharmacol. | pmid:27151496 |
| Dong GZ et al. | AMPK activation by isorhamnetin protects hepatocytes against oxidative stress and mitochondrial dysfunction. | 2014 | Eur. J. Pharmacol. | pmid:24972246 |
| Li YC et al. | Luteolin Suppresses Inflammatory Mediator Expression by Blocking the Akt/NFκB Pathway in Acute Lung Injury Induced by Lipopolysaccharide in Mice. | 2012 | Evid Based Complement Alternat Med | pmid:22203870 |
| Zhang N et al. | Isorhamnetin protects rat ventricular myocytes from ischemia and reperfusion injury. | 2011 | Exp. Toxicol. Pathol. | pmid:19815400 |
| da Silva EL et al. | Quercetin metabolites inhibit copper ion-induced lipid peroxidation in rat plasma. | 1998 | FEBS Lett. | pmid:9688581 |
| Lall N et al. | Antiviral and antituberculous activity of Helichrysum melanacme constituents. | 2006 | Fitoterapia | pmid:16529879 |
| Krenn L et al. | Contribution of methylated exudate flavonoids to the anti-inflammatory activity of Grindelia robusta. | 2009 | Fitoterapia | pmid:19278665 |
| Granica S et al. | Antioxidant and anti-inflammatory flavonol glucuronides from Polygonum aviculare L. | 2013 | Fitoterapia | pmid:24028968 |
| Gudej J and Nazaruk J | Flavonol glycosides from the flowers of Bellis perennis. | 2001 | Fitoterapia | pmid:11677029 |
| Wang W et al. | Enhanced dissolution rate and oral bioavailability of Ginkgo biloba extract by preparing solid dispersion via hot-melt extrusion. | 2015 | Fitoterapia | pmid:25446043 |
| Chen ZP et al. | Comparative pharmacokinetics and bioavailability studies of quercetin, kaempferol and isorhamnetin after oral administration of Ginkgo biloba extracts, Ginkgo biloba extract phospholipid complexes and Ginkgo biloba extract solid dispersions in rats. | 2010 | Fitoterapia | pmid:20603197 |
| Xie Y et al. | Phytic acid enhances the oral absorption of isorhamnetin, quercetin, and kaempferol in total flavones of Hippophae rhamnoides L. | 2014 | Fitoterapia | pmid:24462958 |
| Li G et al. | Pharmacokinetic properties of isorhamnetin, kaempferol and quercetin after oral gavage of total flavones of Hippophae rhamnoides L. in rats using a UPLC-MS method. | 2012 | Fitoterapia | pmid:22056665 |
| Guo R et al. | Comparative assessment of phytochemical profiles, antioxidant and antiproliferative activities of Sea buckthorn (Hippophaë rhamnoides L.) berries. | 2017 | Food Chem | pmid:27979305 |
| Tian Y et al. | Phenolic compounds extracted by acidic aqueous ethanol from berries and leaves of different berry plants. | 2017 | Food Chem | pmid:27855899 |
| Mudrić SŽ et al. | The polyphenolics and carbohydrates as indicators of botanical and geographical origin of Serbian autochthonous clones of red spice paprika. | 2017 | Food Chem | pmid:27664689 |
| Ferreres F et al. | HPLC-DAD-ESI/MS(n) profiling of phenolic compounds from Lathyrus cicera L. seeds. | 2017 | Food Chem | pmid:27507525 |
| Mata A et al. | Contribution to the characterization of Opuntia spp. juices by LC-DAD-ESI-MS/MS. | 2016 | Food Chem | pmid:27211682 |
| Juániz I et al. | Influence of heat treatment on antioxidant capacity and (poly)phenolic compounds of selected vegetables. | 2016 | Food Chem | pmid:26616976 |
| Liu H et al. | Solid-phase extraction of flavonoids in honey samples using carbamate-embedded triacontyl-modified silica sorbent. | 2016 | Food Chem | pmid:26988475 |
| Choi KC et al. | Inhibitory effects of quercetin on aflatoxin B1-induced hepatic damage in mice. | 2010 | Food Chem. Toxicol. | pmid:20621152 |
| Sabini MC et al. | Evaluation of the cytotoxicity, genotoxicity and apoptotic induction of an aqueous extract of Achyrocline satureioides (Lam.) DC. | 2013 | Food Chem. Toxicol. | pmid:23948353 |