MeSH term | MeSH ID | Detail |
---|---|---|
Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
3-O-Methylquercetin is a lipid of Polyketides (PK) class. 3-o-methylquercetin is associated with abnormalities such as Colitis, Hemorrhagic diarrhea and Diabetes. The involved functions are known as Inflammation, Trans-Activation (Genetics), Signal Transduction, Binding, Competitive and Antiinflammatory Effect. 3-o-methylquercetin often locates in Mucous Membrane. The associated genes with 3-O-Methylquercetin are IL2 gene, Human gene and ABCB1 gene. The related experimental models are Streptozotocin Diabetes.
To understand associated biological information of 3-O-Methylquercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
3-O-Methylquercetin is suspected in Colitis, Hemorrhagic diarrhea, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 3-O-Methylquercetin
MeSH term | MeSH ID | Detail |
---|---|---|
Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
Streptozotocin Diabetes are used in the study 'Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway.' (Dou W et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
pmid: | ||||
Ader P et al. | Bioavailability and metabolism of the flavonol quercetin in the pig. | 2000 | Free Radic. Biol. Med. | pmid:10832067 |
Schneider H et al. | Degradation of quercetin-3-glucoside in gnotobiotic rats associated with human intestinal bacteria. | 2000 | J. Appl. Microbiol. | pmid:11123476 |
Morand C et al. | Respective bioavailability of quercetin aglycone and its glycosides in a rat model. | 2000 | Biofactors | pmid:11216481 |
Piskula MK | Factors affecting flavonoids absorption. | 2000 | Biofactors | pmid:11216483 |
Graefe EU et al. | Pharmacokinetics and bioavailability of quercetin glycosides in humans. | 2001 | J Clin Pharmacol | pmid:11361045 |
Murota K et al. | Efficiency of absorption and metabolic conversion of quercetin and its glucosides in human intestinal cell line Caco-2. | 2000 | Arch. Biochem. Biophys. | pmid:11368329 |
Cimanga K et al. | Radical scavenging and xanthine oxidase inhibitory activity of phenolic compounds from Bridelia ferruginea stem bark. | 2001 | J. Pharm. Pharmacol. | pmid:11370716 |
Lu HW et al. | Effect of three flavonoids, 5,7,3',4'-tetrahydroxy-3-methoxy flavone, luteolin, and quercetin, on the stimulus-induced superoxide generation and tyrosyl phosphorylation of proteins in human neutrophil. | 2001 | Arch. Biochem. Biophys. | pmid:11516163 |
Gudej J and Nazaruk J | Flavonol glycosides from the flowers of Bellis perennis. | 2001 | Fitoterapia | pmid:11677029 |
Sikorska M and Matławska I | Kaempferol, isorhamnetin and their glycosides in the flowers of Asclepias syriaca L. | 2001 Jul-Aug | Acta Pol Pharm | pmid:11693731 |
Tang Y et al. | Coumaroyl flavonol glycosides from the leaves of Ginkgo biloba. | 2001 | Phytochemistry | pmid:11738417 |
Apers S et al. | Antiviral activity of simalikalactone D, a quassinoid from Quassia africana. | 2002 | Planta Med. | pmid:11842321 |
Ko WC et al. | Mechanisms of relaxant action of 3-O-methylquercetin in isolated guinea pig trachea. | 2002 | Planta Med. | pmid:11842323 |
Nazaruk J and Gudej J | Qualitative and quantitative chromatographic investigation of flavonoids in Bellis perennis L. | 2001 Sep-Oct | Acta Pol Pharm | pmid:11876448 |
Robin V et al. | Antipoliovirus flavonoids from Psiadia dentata. | 2001 | Antivir. Chem. Chemother. | pmid:11900347 |
Frison-Norrie S and Sporns P | Identification and quantification of flavonol glycosides in almond seedcoats using MALDI-TOF MS. | 2002 | J. Agric. Food Chem. | pmid:11982399 |
Ibarra M et al. | Cardiovascular effects of isorhamnetin and quercetin in isolated rat and porcine vascular smooth muscle and isolated rat atria. | 2002 | Planta Med. | pmid:11988852 |
De Souza KC et al. | LC determination of flavonoids: separation of quercetin, luteolin and 3-O-methylquercetin in Achyrocline satureioides preparations. | 2002 | J Pharm Biomed Anal | pmid:12008157 |
Schieber A et al. | Detection of isorhamnetin glycosides in extracts of apples (Malus domestica cv. "Brettacher") by HPLC-PDA and HPLC-APCI-MS/MS. | 2002 Mar-Apr | Phytochem Anal | pmid:12018028 |
Zou L et al. | Effects of intrinsic fluorescence and quenching on fluorescence-based screening of natural products. | 2002 | Phytomedicine | pmid:12046870 |
Cornish KM et al. | Quercetin metabolism in the lens: role in inhibition of hydrogen peroxide induced cataract. | 2002 | Free Radic. Biol. Med. | pmid:12086683 |
Yokozawa T et al. | Antioxidant effects of isorhamnetin 3,7-di-O-beta-D-glucopyranoside isolated from mustard leaf (Brassica juncea) in rats with streptozotocin-induced diabetes. | 2002 | J. Agric. Food Chem. | pmid:12207497 |
Fattorusso E et al. | Chemical composition of shallot (Allium ascalonicum Hort.). | 2002 | J. Agric. Food Chem. | pmid:12236699 |
Ben Salah H et al. | Flavonol triglycosides from the leaves of Hammada scoparia (POMEL) ILJIN. | 2002 | Chem. Pharm. Bull. | pmid:12237550 |
Smolarz HD | Comparative study on the free flavonoid aglycones in herbs of different species of Polygonum L. | 2002 Mar-Apr | Acta Pol Pharm | pmid:12365607 |
Frison S and Sporns P | Variation in the flavonol glycoside composition of almond seedcoats as determined by maldi-tof mass spectrometry. | 2002 | J. Agric. Food Chem. | pmid:12405781 |
Choi JS et al. | Further isolation of peroxynitrite and 1,1-diphenyl-2-picrylhydrazyl radical scavenging isorhamnetin 7-O-glucoside from the leaves of Brassica juncea L. | 2002 | Arch. Pharm. Res. | pmid:12433194 |
Sesink AL et al. | Intestinal uptake of quercetin-3-glucoside in rats involves hydrolysis by lactase phlorizin hydrolase. | 2003 | J. Nutr. | pmid:12612151 |
Ko WC et al. | 3-O-methylquercetin more selectively inhibits phosphodiesterase subtype 3. | 2003 | Planta Med. | pmid:12709896 |
Green PW et al. | Phenolic compounds on the pod-surface of pigeonpea, Cajanus cajan, mediate feeding behavior of Helicoverpa armigera larvae. | 2003 | J. Chem. Ecol. | pmid:12775145 |
Smolarz HD et al. | Influence of ethyl acetate extract and quercetin-3-methyl ether from Polygonum amphibium on activation lymphocytes from peripheral blood of healthy donor in vitro. | 2003 | Phytother Res | pmid:12916071 |
Czeczot H | The effect of flavonoids on the mutagenic activity of aromatic amines. | 1992 | Acta Biochim. Pol. | pmid:1441824 |
Oh SM and Chung KH | Estrogenic activities of Ginkgo biloba extracts. | 2004 | Life Sci. | pmid:14706564 |
Azuma K et al. | Enhancing effect of lipids and emulsifiers on the accumulation of quercetin metabolites in blood plasma after the short-term ingestion of onion by rats. | 2003 | Biosci. Biotechnol. Biochem. | pmid:14730132 |
Ibarra M et al. | Effects of the flavonoid quercetin and its methylated metabolite isorhamnetin in isolated arteries from spontaneously hypertensive rats. | 2003 | Planta Med. | pmid:14735435 |
Saito A et al. | Protective effects of quercetin and its metabolites on H2O2-induced chromosomal damage to WIL2-NS cells. | 2004 | Biosci. Biotechnol. Biochem. | pmid:14981287 |
Huang TS et al. | Partial purification, kinetic analysis, and amino acid sequence information of a flavonol 3-O-methyltransferase from Serratula tinctoria. | 2004 | Plant Physiol. | pmid:15084728 |
Enomoto S et al. | Inhibitory effect of traditional Turkish folk medicines on aldose reductase (AR) and hematological activity, and on AR inhibitory activity of quercetin-3-O-methyl ether isolated from Cistus laurifolius L. | 2004 | Biol. Pharm. Bull. | pmid:15256757 |
Hong YJ and Mitchell AE | Metabolic profiling of flavonol metabolites in human urine by liquid chromatography and tandem mass spectrometry. | 2004 | J. Agric. Food Chem. | pmid:15506818 |
Justino GC et al. | Plasma quercetin metabolites: structure-antioxidant activity relationships. | 2004 | Arch. Biochem. Biophys. | pmid:15519302 |
Dubber MJ and Kanfer I | High-performance liquid chromatographic determination of selected flavonols in Ginkgo biloba solid oral dosage forms. | 2004 | J Pharm Pharm Sci | pmid:15576009 |
Hubbard GP et al. | Ingestion of quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in humans. | 2004 | J. Thromb. Haemost. | pmid:15613018 |
Ko WC et al. | Suppressive effects of 3-O-methylquercetin on ovalbumin-induced airway hyperresponsiveness. | 2004 | Planta Med. | pmid:15643544 |
Schulz HU et al. | Investigation of the bioavailability of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin following single and multiple oral dosing of a hypericum extract containing tablet. | 2005 | Arzneimittelforschung | pmid:15727160 |
Oh HM et al. | Inhibitory activity of isorhamnetin from Persicaria thunbergii on Farnesyl Protein Transferase. | 2005 | Arch. Pharm. Res. | pmid:15789745 |
Bonaccorsi P et al. | Flavonol glucoside profile of southern Italian red onion (Allium cepa L.). | 2005 | J. Agric. Food Chem. | pmid:15796618 |
Lee YS et al. | Inhibitory effects of isorhamnetin-3-O-beta-D-glucoside from Salicornia herbacea on rat lens aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues. | 2005 | Biol. Pharm. Bull. | pmid:15863906 |
Wang Y et al. | Simultaneous determination of quercetin, kaempferol and isorhamnetin accumulated human breast cancer cells, by high-performance liquid chromatography. | 2005 | J Pharm Biomed Anal | pmid:15905060 |
Wang Y et al. | Involvement of P-glycoprotein in regulating cellular levels of Ginkgo flavonols: quercetin, kaempferol, and isorhamnetin. | 2005 | J. Pharm. Pharmacol. | pmid:15969930 |