3-O-Methylquercetin

3-O-Methylquercetin is a lipid of Polyketides (PK) class. 3-o-methylquercetin is associated with abnormalities such as Colitis, Hemorrhagic diarrhea and Diabetes. The involved functions are known as Inflammation, Trans-Activation (Genetics), Signal Transduction, Binding, Competitive and Antiinflammatory Effect. 3-o-methylquercetin often locates in Mucous Membrane. The associated genes with 3-O-Methylquercetin are IL2 gene, Human gene and ABCB1 gene. The related experimental models are Streptozotocin Diabetes.

Cross Reference

Introduction

To understand associated biological information of 3-O-Methylquercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 3-O-Methylquercetin?

3-O-Methylquercetin is suspected in Colitis, Hemorrhagic diarrhea, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 3-O-Methylquercetin

MeSH term MeSH ID Detail
Cell Transformation, Neoplastic D002471 126 associated lipids
Total 1

PubChem Associated disorders and diseases

What pathways are associated with 3-O-Methylquercetin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 3-O-Methylquercetin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 3-O-Methylquercetin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 3-O-Methylquercetin?

There are no associated biomedical information in the current reference collection.

What genes are associated with 3-O-Methylquercetin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 3-O-Methylquercetin?

Streptozotocin Diabetes

Streptozotocin Diabetes are used in the study 'Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway.' (Dou W et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with 3-O-Methylquercetin

Download all related citations
Per page 10 20 50 100 | Total 307
Authors Title Published Journal PubMed Link
Granica S et al. Novel insight into qualitative standardization of Polygoni avicularis herba (Ph. Eur.). 2013 J Pharm Biomed Anal pmid:23021006
Kim TH et al. Anti-inflammatory activities of isorhamnetin-3-O-galactoside against HMGB1-induced inflammatory responses in both HUVECs and CLP-induced septic mice. 2013 J. Cell. Biochem. pmid:22930571
Zhao G et al. Effects of solid dispersion and self-emulsifying formulations on the solubility, dissolution, permeability and pharmacokinetics of isorhamnetin, quercetin and kaempferol in total flavones of Hippophae rhamnoides L. 2013 Drug Dev Ind Pharm pmid:22757776
Jin JY et al. Isorhamnetin inhibits Prevotella intermedia lipopolysaccharide-induced production of interleukin-6 in murine macrophages via anti-inflammatory heme oxygenase-1 induction and inhibition of nuclear factor-κB and signal transducer and activator of transcription 1 activation. 2013 J. Periodont. Res. pmid:23441850
Gohlke A et al. Bioavailability of quercetin from its aglycone and its glucorhamnoside rutin in lactating dairy cows after intraduodenal administration. 2013 J. Dairy Sci. pmid:23403185
Ge YB et al. Two new flavonol glycosides from the leaves of Elaeagnus pungens. 2013 J Asian Nat Prod Res pmid:23822169
Saud SM et al. Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and β-catenin. 2013 Cancer Res. pmid:23824743
He J et al. A sensitive LC-MS/MS method for simultaneous determination of six flavonoids in rat plasma: application to a pharmacokinetic study of total flavonoids from mulberry leaves. 2013 J Pharm Biomed Anal pmid:23850933
Ku SK et al. Anticoagulant activities of persicarin and isorhamnetin. 2013 Vascul. Pharmacol. pmid:23391847
Guo Y et al. Dietary fat increases quercetin bioavailability in overweight adults. 2013 Mol Nutr Food Res pmid:23319447
Fang R et al. Enhanced profiling of flavonol glycosides in the fruits of sea buckthorn (Hippophae rhamnoides). 2013 J. Agric. Food Chem. pmid:23517173
Ferreres F et al. Phenolic compounds from Jacaranda caroba (Vell.) A. DC.: approaches to neurodegenerative disorders. 2013 Food Chem. Toxicol. pmid:23524314
Yang JH et al. O-Methylated flavonol isorhamnetin prevents acute inflammation through blocking of NF-κB activation. 2013 Food Chem. Toxicol. pmid:23774260
Sun J et al. Isorhamnetin protects against doxorubicin-induced cardiotoxicity in vivo and in vitro. 2013 PLoS ONE pmid:23724057
Sabini MC et al. Evaluation of the cytotoxicity, genotoxicity and apoptotic induction of an aqueous extract of Achyrocline satureioides (Lam.) DC. 2013 Food Chem. Toxicol. pmid:23948353
Granica S et al. Antioxidant and anti-inflammatory flavonol glucuronides from Polygonum aviculare L. 2013 Fitoterapia pmid:24028968
Xu SL et al. Flavonoids induce the expression of synaptic proteins, synaptotagmin, and postsynaptic density protein-95 in cultured rat cortical neuron. 2013 Planta Med. pmid:24243544
Zhang XQ et al. In vitro antioxidant and in vivo anti-inflammatory activities of Ophioglossum thermale. 2012 Am. J. Chin. Med. pmid:22419423
Schrader C et al. Genistein as a potential inducer of the anti-atherogenic enzyme paraoxonase-1: studies in cultured hepatocytes in vitro and in rat liver in vivo. 2012 J. Cell. Mol. Med. pmid:22304296
Sun B et al. Isorhamnetin inhibits Hâ‚‚Oâ‚‚-induced activation of the intrinsic apoptotic pathway in H9c2 cardiomyocytes through scavenging reactive oxygen species and ERK inactivation. 2012 J. Cell. Biochem. pmid:21948481
Ramachandran L et al. Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer. 2012 J. Biol. Chem. pmid:22992727
Wang H et al. Effect of the Miaoyao Fanggan sachet-derived isorhamnetin on TLR2/4 and NKp46 expression in mice. 2012 J Ethnopharmacol pmid:22974546
Cho JM et al. Effects of physiological quercetin metabolites on interleukin-1β-induced inducible NOS expression. 2012 J. Nutr. Biochem. pmid:22221676
Si YX et al. Effects of isorhamnetin on tyrosinase: inhibition kinetics and computational simulation. 2012 Biosci. Biotechnol. Biochem. pmid:22790928
Napolitano JG et al. Complete 1H NMR spectral analysis of ten chemical markers of Ginkgo biloba. 2012 Magn Reson Chem pmid:22730238
Wang DM et al. A new isorhamnetin glycoside and other phenolic compounds from Callianthemum taipaicum. 2012 Molecules pmid:22510608
Shi C et al. Cellular stress response in Eca-109 cells inhibits apoptosis during early exposure to isorhamnetin. 2012 Neoplasma pmid:22489690
Shi ZH et al. Metabolism-based synthesis, biologic evaluation and SARs analysis of O-methylated analogs of quercetin as thrombin inhibitors. 2012 Eur J Med Chem pmid:22647223
Paulke A et al. Isoquercitrin provides better bioavailability than quercetin: comparison of quercetin metabolites in body tissue and brain sections after six days administration of isoquercitrin and quercetin. 2012 Pharmazie pmid:23346761
Wang SD et al. Inhibitory effect of Ginkgo biloba extract on fatty liver: regulation of carnitine palmitoyltransferase 1a and fatty acid metabolism. 2012 J Dig Dis pmid:22988926
Clericuzio M et al. Flavonoid oligoglycosides from Ophioglossum vulgatum L. having wound healing properties. 2012 Planta Med. pmid:22936389
Talib WH et al. Antiproliferative, antimicrobial and apoptosis inducing effects of compounds isolated from Inula viscosa. 2012 Molecules pmid:22418930
Li YC et al. Luteolin Suppresses Inflammatory Mediator Expression by Blocking the Akt/NFκB Pathway in Acute Lung Injury Induced by Lipopolysaccharide in Mice. 2012 Evid Based Complement Alternat Med pmid:22203870
Hoek-van den Hil EF et al. Interference of flavonoids with enzymatic assays for the determination of free fatty acid and triglyceride levels. 2012 Anal Bioanal Chem pmid:22119999
Li G et al. Pharmacokinetic properties of isorhamnetin, kaempferol and quercetin after oral gavage of total flavones of Hippophae rhamnoides L. in rats using a UPLC-MS method. 2012 Fitoterapia pmid:22056665
Xie Q et al. Separation and purification of isorhamnetin 3-sulphate from Flaveria bidentis (L.) Kuntze by counter-current chromatography comparing two kinds of solvent systems. 2012 J Sep Sci pmid:22084024
Egert S et al. Enriched cereal bars are more effective in increasing plasma quercetin compared with quercetin from powder-filled hard capsules. 2012 Br. J. Nutr. pmid:21774840
Wang J et al. Phenolic compounds from Halimodendron halodendron (Pall.) voss and their antimicrobial and antioxidant activities. 2012 Int J Mol Sci pmid:23109858
Li J et al. Quercetin-3-methyl ether suppresses proliferation of mouse epidermal JB6 P+ cells by targeting ERKs. 2012 Carcinogenesis pmid:22139441
Lee SH et al. Persicaria hydropiper (L.) spach and its flavonoid components, isoquercitrin and isorhamnetin, activate the Wnt/β-catenin pathway and inhibit adipocyte differentiation of 3T3-L1 cells. 2011 Phytother Res pmid:21413092
Lee J and Mitchell AE Quercetin and isorhamnetin glycosides in onion (Allium cepa L.): varietal comparison, physical distribution, coproduct evaluation, and long-term storage stability. 2011 J. Agric. Food Chem. pmid:21244009
Zhang N et al. Isorhamnetin protects rat ventricular myocytes from ischemia and reperfusion injury. 2011 Exp. Toxicol. Pathol. pmid:19815400
Boesch-Saadatmandi C et al. Effect of quercetin and its metabolites isorhamnetin and quercetin-3-glucuronide on inflammatory gene expression: role of miR-155. 2011 J. Nutr. Biochem. pmid:20579867
Vitalini S et al. Primula spectabilis Tratt. aerial parts: morphology, volatile compounds and flavonoids. 2011 Phytochemistry pmid:21612805
Wei Y et al. Separation of patuletin-3-O-glucoside, astragalin, quercetin, kaempferol and isorhamnetin from Flaveria bidentis (L.) Kuntze by elution-pump-out high-performance counter-current chromatography. 2011 J Chromatogr A pmid:21329934
Kim JE et al. Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K. 2011 Cancer Prev Res (Phila) pmid:21330379
Moalin M et al. A planar conformation and the hydroxyl groups in the B and C rings play a pivotal role in the antioxidant capacity of quercetin and quercetin derivatives. 2011 Molecules pmid:22105713
Surco-Laos F et al. Effects of O-methylated metabolites of quercetin on oxidative stress, thermotolerance, lifespan and bioavailability on Caenorhabditis elegans. 2011 Food Funct pmid:21776484
Yang ZG et al. Inhibitory effects of constituents from Euphorbia lunulata on differentiation of 3T3-L1 cells and nitric oxide production in RAW264.7 cells. 2011 Molecules pmid:21959301
Rajbhandari R et al. Determination of cranberry phenolic metabolites in rats by liquid chromatography-tandem mass spectrometry. 2011 J. Agric. Food Chem. pmid:21634376
Choi KC et al. Inhibitory effects of quercetin on aflatoxin B1-induced hepatic damage in mice. 2010 Food Chem. Toxicol. pmid:20621152
Holzschuh MH et al. Identification and stability of a new bichalcone in Achyrocline satureioides spray dried powder. 2010 Pharmazie pmid:21038841
Garrido I et al. Targeted analysis of conjugated and microbial-derived phenolic metabolites in human urine after consumption of an almond skin phenolic extract. 2010 J. Nutr. pmid:20739450
Raja MK et al. A comprehensive review on Nymphaea stellata: A traditionally used bitter. 2010 J Adv Pharm Technol Res pmid:22247863
Fernández-López JA et al. Determination of antioxidant constituents in cactus pear fruits. 2010 Plant Foods Hum Nutr pmid:20811778
Ozgen U et al. A new sulfated alpha-ionone glycoside from Sonchus erzincanicus Matthews. 2010 Molecules pmid:20428066
Cao J et al. The relationship between fasting plasma concentrations of selected flavonoids and their ordinary dietary intake. 2010 Br. J. Nutr. pmid:19747418
Rupasinghe HP et al. Absorption and tissue distribution of dietary quercetin and quercetin glycosides of apple skin in broiler chickens. 2010 J. Sci. Food Agric. pmid:20393998
An D et al. Changes of metabolic profiles in urine after oral administration of quercetin in rats. 2010 Food Chem. Toxicol. pmid:20304023
Rangel-Ordóñez L et al. Plasma levels and distribution of flavonoids in rat brain after single and repeated doses of standardized Ginkgo biloba extract EGb 761®. 2010 Planta Med. pmid:20486074
Chen ZP et al. Comparative pharmacokinetics and bioavailability studies of quercetin, kaempferol and isorhamnetin after oral administration of Ginkgo biloba extracts, Ginkgo biloba extract phospholipid complexes and Ginkgo biloba extract solid dispersions in rats. 2010 Fitoterapia pmid:20603197
Qu L et al. Protective effects of flavonoids against oxidative stress induced by simulated microgravity in SH-SY5Y cells. 2010 Neurochem. Res. pmid:20571914
Park S and Choi J Inhibition of beta-catenin/Tcf signaling by flavonoids. 2010 J. Cell. Biochem. pmid:20564233
Lee J et al. Isorhamnetin-induced anti-adipogenesis is mediated by stabilization of beta-catenin protein. 2010 Life Sci. pmid:20097210
Olsson ME et al. Quercetin and isorhamnetin in sweet and red cultivars of onion (Allium cepa L.) at harvest, after field curing, heat treatment, and storage. 2010 J. Agric. Food Chem. pmid:20099844
Jaramillo S et al. The flavonol isorhamnetin exhibits cytotoxic effects on human colon cancer cells. 2010 J. Agric. Food Chem. pmid:20923189
Wang J et al. Preparative separation of phenolic compounds from Halimodendron halodendron by high-speed counter-current chromatography. 2010 Molecules pmid:20877205
Xia F et al. Simultaneous determination of copper, lead, and cadmium at hexagonal mesoporous silica immobilized quercetin modified carbon paste electrode. 2010 J Autom Methods Manag Chem pmid:20445747
Krenn L et al. Contribution of methylated exudate flavonoids to the anti-inflammatory activity of Grindelia robusta. 2009 Fitoterapia pmid:19278665
Winterbone MS et al. Physiologically relevant metabolites of quercetin have no effect on adhesion molecule or chemokine expression in human vascular smooth muscle cells. 2009 Atherosclerosis pmid:18489909
Li L et al. Identification and bioactivities of resveratrol oligomers and flavonoids from Carex folliculata seeds. 2009 J. Agric. Food Chem. pmid:19627089
Søltoft M et al. Pressurised liquid extraction of flavonoids in onions. Method development and validation. 2009 Talanta pmid:19782226
Kawai Y et al. Different profiles of quercetin metabolites in rat plasma: comparison of two administration methods. 2009 Biosci. Biotechnol. Biochem. pmid:19270373
Matsukawa N et al. Nondigestible saccharides suppress the bacterial degradation of quercetin aglycone in the large intestine and enhance the bioavailability of quercetin glucoside in rats. 2009 J. Agric. Food Chem. pmid:19807098
Okoko T and Oruambo IF Inhibitory activity of quercetin and its metabolite on lipopolysaccharide-induced activation of macrophage U937 cells. 2009 Food Chem. Toxicol. pmid:19271315
Lodi F et al. Glucuronidated and sulfated metabolites of the flavonoid quercetin prevent endothelial dysfunction but lack direct vasorelaxant effects in rat aorta. 2009 Atherosclerosis pmid:18801486
Lee J et al. Isorhamnetin represses adipogenesis in 3T3-L1 cells. 2009 Obesity (Silver Spring) pmid:18948972
Larmo PS et al. Effect of a low dose of sea buckthorn berries on circulating concentrations of cholesterol, triacylglycerols, and flavonols in healthy adults. 2009 Eur J Nutr pmid:19288149
Wang Z et al. Simultaneous determination of six herbal components in intestinal perfusate by high-performance liquid chromatography. 2009 Biomed. Chromatogr. pmid:19309764
Hölscher D et al. Matrix-free UV-laser desorption/ionization (LDI) mass spectrometric imaging at the single-cell level: distribution of secondary metabolites of Arabidopsis thaliana and Hypericum species. 2009 Plant J. pmid:19732382
Boesch-Saadatmandi C et al. Effect of apoE genotype and dietary quercetin on blood lipids and TNF-alpha levels in apoE3 and apoE4 targeted gene replacement mice. 2009 Br. J. Nutr. pmid:18986596
Pengfei L et al. Antioxidant properties of isolated isorhamnetin from the sea buckthorn marc. 2009 Plant Foods Hum Nutr pmid:19444611
Fasolo D et al. Development of topical nanoemulsions containing quercetin and 3-O-methylquercetin. 2009 Pharmazie pmid:20099516
Romero M et al. Quercetin inhibits vascular superoxide production induced by endothelin-1: Role of NADPH oxidase, uncoupled eNOS and PKC. 2009 Atherosclerosis pmid:18436224
Vukics V et al. Analysis of heartsease (Viola tricolor L.) flavonoid glycosides by micro-liquid chromatography coupled to multistage mass spectrometry. 2008 J Chromatogr A pmid:18514209
Wang XM et al. Two new flavonol glycosides from Sarcopyramis bodinieri var. delicate. 2008 Molecules pmid:18596665
Papiez MA et al. The changes of antioxidant defense system caused by quercetin administration do not lead to DNA damage and apoptosis in the spleen and bone marrow cells of rats. 2008 Food Chem. Toxicol. pmid:18602965
Paulke A et al. St. John's wort flavonoids and their metabolites show antidepressant activity and accumulate in brain after multiple oral doses. 2008 Pharmazie pmid:18468390
Olszewska M Separation of quercetin, sexangularetin, kaempferol and isorhamnetin for simultaneous HPLC determination of flavonoid aglycones in inflorescences, leaves and fruits of three Sorbus species. 2008 J Pharm Biomed Anal pmid:18635332
Bieger J et al. Tissue distribution of quercetin in pigs after long-term dietary supplementation. 2008 J. Nutr. pmid:18641184
Lee HJ et al. Mitochondria-cytochrome C-caspase-9 cascade mediates isorhamnetin-induced apoptosis. 2008 Cancer Lett. pmid:18617322
Egert S et al. Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans. 2008 J. Nutr. pmid:18716159
Lee SU et al. Flavonoid content in fresh, home-processed, and light-exposed onions and in dehydrated commercial onion products. 2008 J. Agric. Food Chem. pmid:18759442
Neznanov N et al. Quercetinase pirin makes poliovirus replication resistant to flavonoid quercetin. 2008 DNA Cell Biol. pmid:18067462
Liu AL et al. Study of the electrochemical behavior of isorhamnetin on a glassy carbon electrode and its application. 2008 Talanta pmid:18804639
Lan K et al. Intra-herb pharmacokinetics interaction between quercetin and isorhamentin. 2008 Acta Pharmacol. Sin. pmid:18954533
Suzuki H et al. Metabolic profiling of flavonoids in Lotus japonicus using liquid chromatography Fourier transform ion cyclotron resonance mass spectrometry. 2008 Phytochemistry pmid:17669449
Steffen Y et al. Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase. 2008 Arch. Biochem. Biophys. pmid:17996190
Kim JY et al. In vitro anti-inflammatory activity of 3-O-methyl-flavones isolated from Siegesbeckia glabrescens. 2008 Bioorg. Med. Chem. Lett. pmid:18178435
Sobolev VS et al. Spermidine and flavonoid conjugates from peanut (Arachis hypogaea) flowers. 2008 J. Agric. Food Chem. pmid:18412366